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MiR-205 serves as a prognostic factor and suppresses proliferation and invasion by targeting insulin-like growth factor receptor 1 in human cervical cancer.

Abstract MicroRNAs are a kind of small and non-coding RNAs, which have been demonstrated to play an important role in the progression of human cervical cancer. Here, we found that the expression of miR-205 was low in cervical cancer cell lines and tissues, compared with matched non-tumor tissues and human endocervical epithelial cells. Also, miR-205 was inversely correlated with histological differentiation, metastasis, International Federation of Gynecology and Obstetrics stage, and the expression of insulin-like growth factor receptor 1 messenger RNA and protein. Besides, miR-205 or insulin-like growth factor receptor 1 expression is an independent prognostic factor. Mechanically, ectopic expression of miR-205 decreased proliferation, colony formation, and some proliferation/apoptosis-related proteins in cervical cancer cells. Ectopic expression of miR-205 caused G1 arrest. Luciferase reporter assays confirmed that binding of miR-205 to the 3' untranslated region of insulin-like growth factor receptor 1 may potentially decrease the expression of insulin-like growth factor receptor 1. Notably, insulin-like growth factor receptor 1 overexpression attenuated the inhibitory effects of miR-205 on cell proliferation and invasion, while small interfering RNA-insulin-like growth factor receptor 1 enhanced the inhibitory effects of miR-205 on cell proliferation and invasion. In conclusion, our findings suggested that miR-205 serves as a prognostic factor and suppresses proliferation and invasion by targeting insulin-like growth factor receptor 1 in human cervical cancer. Thus, miR-205/insulin-like growth factor receptor 1 pathway may be of great benefit to cervical cancer patients.
PMID
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Authors

Mayor MeshTerms
Keywords

MiR-205

cervical cancer

insulin-like growth factor receptor 1

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28651495
OWN - NLM
STAT- MEDLINE
DA  - 20170627
DCOM- 20170710
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - MiR-205 serves as a prognostic factor and suppresses proliferation and invasion
      by targeting insulin-like growth factor receptor 1 in human cervical cancer.
PG  - 1010428317701308
LID - 10.1177/1010428317701308 [doi]
AB  - MicroRNAs are a kind of small and non-coding RNAs, which have been demonstrated
      to play an important role in the progression of human cervical cancer. Here, we
      found that the expression of miR-205 was low in cervical cancer cell lines and
      tissues, compared with matched non-tumor tissues and human endocervical
      epithelial cells. Also, miR-205 was inversely correlated with histological
      differentiation, metastasis, International Federation of Gynecology and
      Obstetrics stage, and the expression of insulin-like growth factor receptor 1
      messenger RNA and protein. Besides, miR-205 or insulin-like growth factor
      receptor 1 expression is an independent prognostic factor. Mechanically, ectopic 
      expression of miR-205 decreased proliferation, colony formation, and some
      proliferation/apoptosis-related proteins in cervical cancer cells. Ectopic
      expression of miR-205 caused G1 arrest. Luciferase reporter assays confirmed that
      binding of miR-205 to the 3' untranslated region of insulin-like growth factor
      receptor 1 may potentially decrease the expression of insulin-like growth factor 
      receptor 1. Notably, insulin-like growth factor receptor 1 overexpression
      attenuated the inhibitory effects of miR-205 on cell proliferation and invasion, 
      while small interfering RNA-insulin-like growth factor receptor 1 enhanced the
      inhibitory effects of miR-205 on cell proliferation and invasion. In conclusion, 
      our findings suggested that miR-205 serves as a prognostic factor and suppresses 
      proliferation and invasion by targeting insulin-like growth factor receptor 1 in 
      human cervical cancer. Thus, miR-205/insulin-like growth factor receptor 1
      pathway may be of great benefit to cervical cancer patients.
FAU - Pang, Hui
AU  - Pang H
AD  - Department of Gynecology, Tianjin Baodi Hospital, Baodi Clinical College of
      Tianjin Medical University, Tianjin, China.
FAU - Yue, Xiuying
AU  - Yue X
AD  - Department of Gynecology, Tianjin Baodi Hospital, Baodi Clinical College of
      Tianjin Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MIRN205 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Receptors, Somatomedin)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Adult
MH  - Apoptosis/genetics
MH  - Biomarkers, Tumor/*biosynthesis/genetics
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - HeLa Cells
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - MicroRNAs/*biosynthesis/genetics
MH  - Middle Aged
MH  - Neoplasm Invasiveness/genetics
MH  - Primary Cell Culture
MH  - Prognosis
MH  - Receptor, IGF Type 1/*biosynthesis/genetics
MH  - Receptors, Somatomedin
MH  - Uterine Cervical Neoplasms/*genetics/pathology
OTO - NOTNLM
OT  - MiR-205
OT  - cervical cancer
OT  - insulin-like growth factor receptor 1
EDAT- 2017/06/28 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/28 06:00
AID - 10.1177/1010428317701308 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317701308. doi: 10.1177/1010428317701308.