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Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and promotes cancer cell proliferation, migration, and invasion.

Abstract Laminin γ2 (LAMC2) has been reported to be involved in the development and progression of a variety of tumors. However, its function in human colorectal cancer is unclear. Our study aimed to investigate the role of laminin γ2 in colorectal cancer. We first performed the multiple Kaplan-Meier survival analysis of laminin γ2 in a cohort of Gene Expression Omnibus datasets and evaluated its relationship with clinical outcomes of colorectal cancer patients. Then, we established stable colorectal cancer cell lines with laminin γ2 overexpression and examined the functional assays in vitro. Finally the expression pattern of laminin γ2 in colorectal cancer clinical samples was analyzed by immunohistochemistry and quantitative real-time polymerase chain reaction. We found that laminin γ2 was significantly correlated with poor clinical outcomes such as disease-specific, recurrence-free, disease-free, and overall survival in colorectal cancer. Moreover, stably overexpressing laminin γ2 promoted proliferation, migration, and invasion of colorectal cancer cells. In addition, overexpressed laminin γ2 was identified in tumor tissues compared with paired adjacent normal tissues and was related to tumor-node-metastasis stage (p = 0.001) and lymph node metastasis (p < 0.001). In summary, our results strongly suggest that laminin γ2 may be a potential prognostic biomarker and therapeutic target in colorectal cancer.
PMID
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Authors

Mayor MeshTerms
Keywords

Colorectal cancer

biomarker

diagnosis

laminin γ2

prognosis

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start


 


PMID- 28653882
OWN - NLM
STAT- MEDLINE
DA  - 20170627
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and
      promotes cancer cell proliferation, migration, and invasion.
PG  - 1010428317705849
LID - 10.1177/1010428317705849 [doi]
AB  - Laminin gamma2 (LAMC2) has been reported to be involved in the development and
      progression of a variety of tumors. However, its function in human colorectal
      cancer is unclear. Our study aimed to investigate the role of laminin gamma2 in
      colorectal cancer. We first performed the multiple Kaplan-Meier survival analysis
      of laminin gamma2 in a cohort of Gene Expression Omnibus datasets and evaluated
      its relationship with clinical outcomes of colorectal cancer patients. Then, we
      established stable colorectal cancer cell lines with laminin gamma2
      overexpression and examined the functional assays in vitro. Finally the
      expression pattern of laminin gamma2 in colorectal cancer clinical samples was
      analyzed by immunohistochemistry and quantitative real-time polymerase chain
      reaction. We found that laminin gamma2 was significantly correlated with poor
      clinical outcomes such as disease-specific, recurrence-free, disease-free, and
      overall survival in colorectal cancer. Moreover, stably overexpressing laminin
      gamma2 promoted proliferation, migration, and invasion of colorectal cancer
      cells. In addition, overexpressed laminin gamma2 was identified in tumor tissues 
      compared with paired adjacent normal tissues and was related to
      tumor-node-metastasis stage (p = 0.001) and lymph node metastasis (p &lt; 0.001). In
      summary, our results strongly suggest that laminin gamma2 may be a potential
      prognostic biomarker and therapeutic target in colorectal cancer.
FAU - Huang, Dandan
AU  - Huang D
AD  - 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Gastrointestinal Surgery III, Peking University Cancer 
      Hospital &amp; Institute, Beijing, China.
FAU - Du, Changzheng
AU  - Du C
AD  - 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Gastrointestinal Surgery III, Peking University Cancer 
      Hospital &amp; Institute, Beijing, China.
FAU - Ji, Dengbo
AU  - Ji D
AD  - 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Gastrointestinal Surgery III, Peking University Cancer 
      Hospital &amp; Institute, Beijing, China.
FAU - Xi, Jianzhong
AU  - Xi J
AD  - 2 Department of Biomedical Engineering, College of Engineering, Peking
      University, Beijing, China.
FAU - Gu, Jin
AU  - Gu J
AD  - 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Gastrointestinal Surgery III, Peking University Cancer 
      Hospital &amp; Institute, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (LAMC2 protein, human)
RN  - 0 (Laminin)
SB  - IM
MH  - Biomarkers, Tumor/*biosynthesis/genetics
MH  - Cell Movement/genetics
MH  - Cell Proliferation/*genetics
MH  - Colorectal Neoplasms/*genetics/pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laminin/*biosynthesis/genetics
MH  - Male
MH  - Neoplasm Invasiveness/genetics
MH  - Prognosis
OTO - NOTNLM
OT  - Colorectal cancer
OT  - biomarker
OT  - diagnosis
OT  - laminin gamma2
OT  - prognosis
EDAT- 2017/06/28 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/28 06:00
AID - 10.1177/1010428317705849 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317705849. doi: 10.1177/1010428317705849.