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DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients.

Abstract DJ-1 is a novel oncogene that can transform NIH3T3 cells in cooperation with the activated ras gene. DJ-1 appears to have its greatest effect on tumourigenesis, and it may have a greater impact on early-stage lung cancers. In this study, we proposed to investigate the clinical value of DJ-1 protein in the early diagnosis of lung cancer and compared its diagnostic value with other biomarkers. Preoperative serum DJ-1 levels were measured in 300 lung cancer patients and compared with benign pulmonary disease (n = 44) and healthy volunteers (n = 64). Using tissue microarrays and immunohistochemical analyses, we compared the DJ-1 expression between the primary squamous cell carcinoma tumours and matched metastatic tissues from a lymph node. The baseline preoperative serum DJ-1 of lung cancer patients was significantly higher than that of benign diseases and healthy controls (p < 0.001). In the early-stage subgroup, the median DJ-1 concentration (ng/mL) was significantly higher than that of the advanced stage (12.90 vs 7.75, p < 0.05). Using immunohistochemistry, we observed that the DJ-1 staining intensity was generally weaker and less common in the metastatic tissues compared with that in the primary tumour (McNemar-Bowker Test, p = 0.008). DJ-1 was highly expressed in the early stage of lung cancer, and its expression was significantly decreased after metastasis. Therefore, DJ-1 may be a potential biomarker for the early diagnosis and monitoring of lung cancer metastasis.
PMID
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Authors

Mayor MeshTerms
Keywords

DJ-1

Lung cancer

early diagnosis

immunohistochemistry

tumour marker

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28653888
OWN - NLM
STAT- MEDLINE
DA  - 20170627
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients.
PG  - 1010428317714625
LID - 10.1177/1010428317714625 [doi]
AB  - DJ-1 is a novel oncogene that can transform NIH3T3 cells in cooperation with the 
      activated ras gene. DJ-1 appears to have its greatest effect on tumourigenesis,
      and it may have a greater impact on early-stage lung cancers. In this study, we
      proposed to investigate the clinical value of DJ-1 protein in the early diagnosis
      of lung cancer and compared its diagnostic value with other biomarkers.
      Preoperative serum DJ-1 levels were measured in 300 lung cancer patients and
      compared with benign pulmonary disease (n = 44) and healthy volunteers (n = 64). 
      Using tissue microarrays and immunohistochemical analyses, we compared the DJ-1
      expression between the primary squamous cell carcinoma tumours and matched
      metastatic tissues from a lymph node. The baseline preoperative serum DJ-1 of
      lung cancer patients was significantly higher than that of benign diseases and
      healthy controls (p &lt; 0.001). In the early-stage subgroup, the median DJ-1
      concentration (ng/mL) was significantly higher than that of the advanced stage
      (12.90 vs 7.75, p &lt; 0.05). Using immunohistochemistry, we observed that the DJ-1 
      staining intensity was generally weaker and less common in the metastatic tissues
      compared with that in the primary tumour (McNemar-Bowker Test, p = 0.008). DJ-1
      was highly expressed in the early stage of lung cancer, and its expression was
      significantly decreased after metastasis. Therefore, DJ-1 may be a potential
      biomarker for the early diagnosis and monitoring of lung cancer metastasis.
FAU - Han, Binbin
AU  - Han B
AD  - 1 Department of Clinical Laboratory, National Cancer Center/Cancer Hospital,
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,
      100021, China.
FAU - Wang, Jiwen
AU  - Wang J
AD  - 2 Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
FAU - Gao, Jia
AU  - Gao J
AD  - 1 Department of Clinical Laboratory, National Cancer Center/Cancer Hospital,
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,
      100021, China.
FAU - Feng, Shana
AU  - Feng S
AD  - 1 Department of Clinical Laboratory, National Cancer Center/Cancer Hospital,
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,
      100021, China.
FAU - Zhu, Yu
AU  - Zhu Y
AD  - 1 Department of Clinical Laboratory, National Cancer Center/Cancer Hospital,
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,
      100021, China.
FAU - Li, Xuexiang
AU  - Li X
AD  - 1 Department of Clinical Laboratory, National Cancer Center/Cancer Hospital,
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,
      100021, China.
FAU - Xiao, Ting
AU  - Xiao T
AD  - 3 State Key Laboratory of Molecular Oncology, Department of Etiology and
      Carcinogenesis, National Cancer Center/ Cancer Hospital, Chinese Academy of
      Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Qi, Jun
AU  - Qi J
AD  - 1 Department of Clinical Laboratory, National Cancer Center/Cancer Hospital,
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,
      100021, China.
FAU - Cui, Wei
AU  - Cui W
AD  - 1 Department of Clinical Laboratory, National Cancer Center/Cancer Hospital,
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,
      100021, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.1.2.- (PARK7 protein, human)
RN  - EC 3.1.2.- (Protein Deglycase DJ-1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/biosynthesis/*genetics
MH  - Carcinogenesis/genetics
MH  - Early Detection of Cancer
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/*diagnosis/*genetics/pathology
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Protein Deglycase DJ-1/biosynthesis/*genetics
OTO - NOTNLM
OT  - DJ-1
OT  - Lung cancer
OT  - early diagnosis
OT  - immunohistochemistry
OT  - tumour marker
EDAT- 2017/06/28 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/28 06:00
AID - 10.1177/1010428317714625 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317714625. doi: 10.1177/1010428317714625.