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Expression of Fra-1 in human hepatocellular carcinoma and its prognostic significance.

Abstract This study aimed to explore the clinical significance and prognostic value of Fra-1 in hepatocellular carcinoma patients after curative resection. Fra-1 expression was investigated using a combination of techniques: immunohistochemistry for 66 samples of hepatocellular carcinoma and quantitative real-time polymerase chain reaction and western blotting assays for 19 matched hepatocellular carcinoma specimens. Fra-1 was present in 38 of 66 (57.6%) tumor tissues, with intense staining in the nuclei. There was also positive staining in 14 of 66 (21.2%) adjacent peritumoral tissues, with weak staining in the cytoplasm. Quantitative real-time polymerase chain reaction and western blotting assays confirmed higher expression of Fra-1 messenger RNA and Fra-1 protein in tumor tissues than adjacent non-tumor tissues for 19 hepatocellular carcinoma samples (pā€‰<ā€‰0.001). Positive expression of Fra-1 was significantly related to vascular invasion and serum alpha-fetoprotein. Kaplan-Meier survival analysis found that overexpressed Fra-1 was correlated with poor overall survival and disease-free survival. Multivariate analysis identified Fra-1 as an independent prognostic factor. Fra-1 may be involved in the progress of hepatocellular carcinoma and could be a promising molecular candidate in the diagnosis and treatment of hepatocellular carcinoma.
PMID
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Authors

Mayor MeshTerms
Keywords

Fra-1

hepatocellular carcinoma

prognosis

serum alpha-fetoprotein

vascular invasion

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28653890
OWN - NLM
STAT- In-Process
DA  - 20170627
LR  - 20170627
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Expression of Fra-1 in human hepatocellular carcinoma and its prognostic
      significance.
PG  - 1010428317709635
LID - 10.1177/1010428317709635 [doi]
AB  - This study aimed to explore the clinical significance and prognostic value of
      Fra-1 in hepatocellular carcinoma patients after curative resection. Fra-1
      expression was investigated using a combination of techniques:
      immunohistochemistry for 66 samples of hepatocellular carcinoma and quantitative 
      real-time polymerase chain reaction and western blotting assays for 19 matched
      hepatocellular carcinoma specimens. Fra-1 was present in 38 of 66 (57.6%) tumor
      tissues, with intense staining in the nuclei. There was also positive staining in
      14 of 66 (21.2%) adjacent peritumoral tissues, with weak staining in the
      cytoplasm. Quantitative real-time polymerase chain reaction and western blotting 
      assays confirmed higher expression of Fra-1 messenger RNA and Fra-1 protein in
      tumor tissues than adjacent non-tumor tissues for 19 hepatocellular carcinoma
      samples (p &lt; 0.001). Positive expression of Fra-1 was significantly related to
      vascular invasion and serum alpha-fetoprotein. Kaplan-Meier survival analysis
      found that overexpressed Fra-1 was correlated with poor overall survival and
      disease-free survival. Multivariate analysis identified Fra-1 as an independent
      prognostic factor. Fra-1 may be involved in the progress of hepatocellular
      carcinoma and could be a promising molecular candidate in the diagnosis and
      treatment of hepatocellular carcinoma.
FAU - Gao, Xiao-Qiang
AU  - Gao XQ
AD  - 1 Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery and Department 
      of Hepatic Surgery, Anhui Provincial Hospital, Anhui Medical University, Hefei,
      China.
FAU - Ge, Yong-Sheng
AU  - Ge YS
AD  - 1 Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery and Department 
      of Hepatic Surgery, Anhui Provincial Hospital, Anhui Medical University, Hefei,
      China.
FAU - Shu, Qing-Hua
AU  - Shu QH
AD  - 2 Department of General Surgery, Nanjing Second People's Hospital, Nanjing,
      China.
FAU - Ma, Hua-Xing
AU  - Ma HX
AD  - 3 Department of Emergency, The Affiliated Hospital of Guizhou Medical University,
      Guizhou, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
OTO - NOTNLM
OT  - Fra-1
OT  - hepatocellular carcinoma
OT  - prognosis
OT  - serum alpha-fetoprotein
OT  - vascular invasion
EDAT- 2017/06/28 06:00
MHDA- 2017/06/28 06:00
CRDT- 2017/06/28 06:00
AID - 10.1177/1010428317709635 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317709635. doi: 10.1177/1010428317709635.