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Progress in the treatment of esophageal neuroendocrine carcinoma.

Abstract Esophageal neuroendocrine neoplasms are rare. With the improvement and popularization of diagnostic methods, the morbidity statistics have increased annually in recent years. There are currently no treatment guidelines for esophageal neuroendocrine neoplasms, and surgery is the only cure. This usually involves radical surgery when the tumor is limited to the primary site or when only regional lymph node metastasis occurs. Surgical treatment is key to treating esophageal neuroendocrine neoplasms, but combined treatment with chemotherapy and radiotherapy can significantly improve patient survival. The effect of radiotherapy alone on this disease is poor. However, targeted endocrine therapy can improve endocrine hormone symptoms. The prognosis of patients with esophageal neuroendocrine neoplasms is mainly determined by the pathological stage. With the development of molecular biology techniques, the combination of targeted drugs and traditional chemotherapy is expected to provide novel ideas and directions for the treatment of esophageal neuroendocrine neoplasms in the coming years. In this article, the status of esophageal neuroendocrine tumor treatments was reviewed in detail.
PMID
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Authors

Mayor MeshTerms

Molecular Targeted Therapy

Keywords

Esophageal neuroendocrine carcinoma

biological therapy

chemotherapy

endoscopic treatment

radiotherapy

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28653897
OWN - NLM
STAT- MEDLINE
DA  - 20170627
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Progress in the treatment of esophageal neuroendocrine carcinoma.
PG  - 1010428317711313
LID - 10.1177/1010428317711313 [doi]
AB  - Esophageal neuroendocrine neoplasms are rare. With the improvement and
      popularization of diagnostic methods, the morbidity statistics have increased
      annually in recent years. There are currently no treatment guidelines for
      esophageal neuroendocrine neoplasms, and surgery is the only cure. This usually
      involves radical surgery when the tumor is limited to the primary site or when
      only regional lymph node metastasis occurs. Surgical treatment is key to treating
      esophageal neuroendocrine neoplasms, but combined treatment with chemotherapy and
      radiotherapy can significantly improve patient survival. The effect of
      radiotherapy alone on this disease is poor. However, targeted endocrine therapy
      can improve endocrine hormone symptoms. The prognosis of patients with esophageal
      neuroendocrine neoplasms is mainly determined by the pathological stage. With the
      development of molecular biology techniques, the combination of targeted drugs
      and traditional chemotherapy is expected to provide novel ideas and directions
      for the treatment of esophageal neuroendocrine neoplasms in the coming years. In 
      this article, the status of esophageal neuroendocrine tumor treatments was
      reviewed in detail.
FAU - Ma, Zheng
AU  - Ma Z
AD  - Department of Thoracic Surgery, The First Hospital of Jilin University,
      Changchun, China.
FAU - Cai, Hongfei
AU  - Cai H
AD  - Department of Thoracic Surgery, The First Hospital of Jilin University,
      Changchun, China.
FAU - Cui, Youbin
AU  - Cui Y
AD  - Department of Thoracic Surgery, The First Hospital of Jilin University,
      Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
SB  - IM
MH  - Carcinoma, Neuroendocrine/*drug therapy/genetics/radiotherapy/surgery
MH  - Combined Modality Therapy
MH  - Drug Delivery Systems
MH  - Esophageal Neoplasms/*drug therapy/genetics/radiotherapy/surgery
MH  - Humans
MH  - *Molecular Targeted Therapy
MH  - Prognosis
OTO - NOTNLM
OT  - Esophageal neuroendocrine carcinoma
OT  - biological therapy
OT  - chemotherapy
OT  - endoscopic treatment
OT  - radiotherapy
EDAT- 2017/06/28 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/28 06:00
AID - 10.1177/1010428317711313 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317711313. doi: 10.1177/1010428317711313.