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PMID- 28653903
OWN - NLM
STAT- MEDLINE
DA  - 20170627
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Biological function of long noncoding RNA snaR in HER2-positive breast cancer
      cells.
PG  - 1010428317707374
LID - 10.1177/1010428317707374 [doi]
AB  - PURPOSE: Long noncoding RNA, snaR (small NF90-associated RNA), has been reported 
      to be upregulated in various cancer cell lines. We evaluated the additional role 
      of snaR in HER2-positive breast cancer cell lines. METHODS: We explored changes
      of expression of snaR among the selected long noncoding RNAs which have a
      potential in cancer proliferation or progression. The proliferation, migration,
      and invasion of HER2-positive breast cancer cells (SK-BR3) were evaluated by snaR
      with RNA interruption in 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium
      bromide, wound-healing assay, and Transwell assay. RESULTS: The expression of
      snaR was remarkably upregulated in SK-BR3 cell lines together with ANRIL, while
      the SFMBT2 was downregulated in SK-BR3 cell lines. Although Nespas, 7SK, PSF
      inhibiting RNA, mascRNA, Hoxa11as, NRON, AK023948, MER11C, p53 mRNA, CAR
      Intergenic 10, HUC 1 and 2, ZFAS1, SCA8, and SNHG5 were also upregulated and UCA1
      was downregulated, the differences were not dominent. Based on the expression
      result, we explored the functional role of snaR in HER2-positive breast cancer.
      Downregulation of snaR with small interfering RNA was identified to significanlty
      inhibit migration as well as proliferation of SK-BR3 cells. CONCLUSION: In this
      study, snaR was identified as upregulated and to play a role in cancer
      progression of HER2-positive breast cancer cells. These results suggest snaR as a
      potential biomarker for HER2-positive breast cancer.
FAU - Lee, Jeeyeon
AU  - Lee J
AD  - 1 Department of Surgery, Kyungpook National University School of Medicine, Daegu,
      Republic of Korea.
FAU - Park, Ho Yong
AU  - Park HY
AD  - 1 Department of Surgery, Kyungpook National University School of Medicine, Daegu,
      Republic of Korea.
FAU - Kim, Wan Wook
AU  - Kim WW
AD  - 1 Department of Surgery, Kyungpook National University School of Medicine, Daegu,
      Republic of Korea.
FAU - Lee, Soo Jung
AU  - Lee SJ
AD  - 2 Department of Hemato-Oncology, Kyungpook National University School of
      Medicine, Daegu, Republic of Korea.
FAU - Jeong, Jae-Hwan
AU  - Jeong JH
AD  - 3 Cell and Matrix Research Institute, Kyungpook National University School of
      Medicine, Daegu, Republic of Korea.
FAU - Kang, Seung Hee
AU  - Kang SH
AD  - 3 Cell and Matrix Research Institute, Kyungpook National University School of
      Medicine, Daegu, Republic of Korea.
FAU - Jung, Jin Hyang
AU  - Jung JH
AD  - 1 Department of Surgery, Kyungpook National University School of Medicine, Daegu,
      Republic of Korea.
AD  - 4 Breast Cancer Center, Kyungpook National University School of Medicine, Daegu, 
      Republic of Korea.
FAU - Chae, Yee Soo
AU  - Chae YS
AD  - 2 Department of Hemato-Oncology, Kyungpook National University School of
      Medicine, Daegu, Republic of Korea.
AD  - 4 Breast Cancer Center, Kyungpook National University School of Medicine, Daegu, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Messenger)
RN  - 0 (long non-coding RNA snaR, human)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Biomarkers, Tumor
MH  - Breast Neoplasms/*genetics/pathology
MH  - Cell Proliferation/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - MCF-7 Cells
MH  - Neoplasm Proteins/*biosynthesis/genetics
MH  - RNA, Long Noncoding/*biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Receptor, ErbB-2/*genetics
MH  - Transcriptional Activation/genetics
OTO - NOTNLM
OT  - HER2-positive
OT  - Long noncoding RNA
OT  - breast
OT  - carcinoma
OT  - snaR
EDAT- 2017/06/28 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/28 06:00
AID - 10.1177/1010428317707374 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317707374. doi: 10.1177/1010428317707374.