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PMID- 28653972
DA  - 20170627
DCOM- 20170707
LR  - 20170707
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 75
IP  - 4
DP  - 2017 Aug 01
TI  - Active HCV Replication but Not HCV or CMV Seropositive Status Is Associated With 
      Incident and Prevalent Type 2 Diabetes in Persons Living With HIV.
PG  - 465-471
LID - 10.1097/QAI.0000000000001443 [doi]
AB  - OBJECTIVE: To analyze the association between chronic hepatitis C virus (HCV) and
      cytomegalovirus (CMV) infections with type 2 diabetes in HIV-infected patients.
      METHODS: HIV-1-infected patients enrolled in ICONA, a prospective cohort study
      involving 42 tertiary care centers in Italy, were selected with the following
      characteristics: for the diabetes incidence analysis, all patients with available
      CMV IgG results (first available test = baseline) and without type 2 diabetes
      were followed until onset of type 2 diabetes, last available clinical follow-up, 
      death or September 30, 2014, whichever occurred first; for the prevalence
      analysis, all ICONA patients were analyzed at their last follow-up visit. Main
      outcome measures were the new onset of type 2 diabetes (incidence analysis) and
      the prevalence of type 2 diabetes at last follow-up. RESULTS: During 38,062
      person-years of follow-up (PYFU) in 6505 individuals, we observed 140 cases of
      incident type 2 diabetes (Incidence rate 3.7, 95% CI: 3.1 to 4.3, per 1000 PYFU).
      In a multivariable Poisson regression model, HCV-antibody (Ab)+/HCV RNA+ patients
      [adjusted relative rate versus HCV-Ab negative 1.73 (95% CI: 1.08 to 2.78)] but
      not HCV Ab+RNA- or CMV IgG+ patients, had a higher risk of diabetes. Among 12,001
      patients, 306 (2.5%) prevalent cases of type 2 diabetes were detected. HCV
      Ab+RNA+ status was independently associated with prevalent diabetes (adjusted
      Odds Ratio vs HCV Ab- 2.49; 95% CI: 1.08 to 5.74), whereas HCV-Ab+/HCV RNA- and
      CMV IgG+ status were not. CONCLUSION: In HIV-infected individuals, active HCV
      replication but not prior HCV exposure or latent CMV infection is associated with
      incident and prevalent type 2 diabetes.
FAU - De Luca, Andrea
AU  - De Luca A
AD  - *Dipartimento di Biotecnologie Mediche, Universita degli Studi di Siena;daggerUOC
      Malattie Infettive Universitarie ed Epatologia, Dipartimento di Medicina Interna 
      e Specialistica, Azienda Ospedaliera Universitaria Senese, Siena, Italy;double
      daggerNational Institute for Infectious Diseases "L Spallanzani, Roma, Italy;
      section signDivision of Infectious Diseases, Hospital San Raffaele, Milan, Italy;
      ||Division of Infectious Diseases, Niguarda Hospital, Milan, Italy; paragraph
      signDepartment of Infectious Diseases, University of Brescia, Brescia,
      Italy;#Division of Infectious Diseases, AO Giovanni XXIII, Bergamo,
      Italy;**Division of Infectious Diseases, University La Sapienza, Polo Pontino,
      Latina, Italy;daggerdaggerINMI "L Spallanzani," Rome, Italy;double daggerdouble
      daggerDivision of Infectious Diseases, University of Modena and Reggio Emilia,
      Modena, Italy; section sign section signDivision of Infectious Diseases,
      University La Sapienza, Polo Pontino, Latina, Italy; and || ||Division of
      Infectious Diseases, University of Milan, San Paolo Hospital, Milan, Italy.
FAU - Lorenzini, Patrizia
AU  - Lorenzini P
FAU - Castagna, Antonella
AU  - Castagna A
FAU - Puoti, Massimo
AU  - Puoti M
FAU - Gianotti, Nicola
AU  - Gianotti N
FAU - Castelli, Francesco
AU  - Castelli F
FAU - Mastroianni, Claudio
AU  - Mastroianni C
FAU - Maggiolo, Franco
AU  - Maggiolo F
FAU - Antinori, Andrea
AU  - Antinori A
FAU - Guaraldi, Giovanni
AU  - Guaraldi G
FAU - Lichtner, Miriam
AU  - Lichtner M
FAU - d'Arminio Monforte, Antonella
AU  - d'Arminio Monforte A
CN  - ICONA Foundation Study
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Hepatitis C Antibodies)
SB  - IM
SB  - X
MH  - Adult
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*immunology/physiopathology
MH  - Female
MH  - HIV Infections/drug therapy/*immunology/physiopathology
MH  - Hepatitis C Antibodies/*immunology
MH  - Hepatitis C, Chronic/drug therapy/*immunology/physiopathology
MH  - Humans
MH  - Incidence
MH  - Italy
MH  - Lymphocyte Activation/*drug effects
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2017/06/28 06:00
MHDA- 2017/07/08 06:00
CRDT- 2017/06/28 06:00
AID - 10.1097/QAI.0000000000001443 [doi]
AID - 00126334-201708010-00012 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2017 Aug 1;75(4):465-471. doi: