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PMID- 28655016
OWN - NLM
STAT- MEDLINE
DA  - 20170627
DCOM- 20170711
LR  - 20170713
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 317
IP  - 24
DP  - 2017 Jun 27
TI  - Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary
      Incontinence: A Randomized Clinical Trial.
PG  - 2493-2501
LID - 10.1001/jama.2017.7220 [doi]
AB  - Importance: Electroacupuncture involving the lumbosacral region may be effective 
      for women with stress urinary incontinence (SUI), but evidence is limited.
      Objective: To assess the effect of electroacupuncture vs sham electroacupuncture 
      for women with SUI. Design, Setting, and Participants: Multicenter, randomized
      clinical trial conducted at 12 hospitals in China and enrolling 504 women with
      SUI between October 2013 and May 2015, with data collection completed in December
      2015. Interventions: Participants were randomly assigned (1:1) to receive 18
      sessions (over 6 weeks) of electroacupuncture involving the lumbosacral region (n
      = 252) or sham electroacupuncture (n = 252) with no skin penetration on sham
      acupoints. Main Outcomes and Measures: The primary outcome was change from
      baseline to week 6 in the amount of urine leakage, measured by the 1-hour pad
      test. Secondary outcomes included mean 72-hour urinary incontinence episodes
      measured by a 72-hour bladder diary (72-hour incontinence episodes). Results:
      Among the 504 randomized participants (mean [SD] age, 55.3 [8.4] years), 482
      completed the study. Mean urine leakage at baseline was 18.4 g for the
      electroacupuncture group and 19.1 g for the sham electroacupuncture group. Mean
      72-hour incontinence episodes were 7.9 for the electroacupuncture group and 7.7
      for the sham electroacupuncture group. At week 6, the electroacupuncture group
      had greater decrease in mean urine leakage (-9.9 g) than the sham
      electroacupuncture group (-2.6 g) with a mean difference of 7.4 g (95% CI, 4.8 to
      10.0; P < .001). During some time periods, the change in the mean 72-hour
      incontinence episodes from baseline was greater with electroacupuncture than sham
      electroacupuncture with between-group differences of 1.0 episode in weeks 1 to 6 
      (95% CI, 0.2-1.7; P = .01), 2.0 episodes in weeks 15 to 18 (95% CI, 1.3-2.7; P < 
      .001), and 2.1 episodes in weeks 27 to 30 (95% CI, 1.3-2.8; P < .001). The
      incidence of treatment-related adverse events was 1.6% in the electroacupuncture 
      group and 2.0% in the sham electroacupuncture group, and all events were
      classified as mild. Conclusions and Relevance: Among women with stress urinary
      incontinence, treatment with electroacupuncture involving the lumbosacral region,
      compared with sham electroacupuncture, resulted in less urine leakage after 6
      weeks. Further research is needed to understand long-term efficacy and the
      mechanism of action of this intervention. Trial Registration: clinicaltrials.gov 
      Identifier: NCT01784172.
FAU - Liu, Zhishun
AU  - Liu Z
AD  - Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese
      Medical Sciences, Beijing, China.
FAU - Xu, Huanfang
AU  - Xu H
AD  - Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing,
      China3Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - He, Liyun
AU  - He L
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese
      Medical Sciences, Beijing, China.
FAU - Chen, Yuelai
AU  - Chen Y
AD  - Yueyang Hospital of Integrated Traditional Chinese and Western Medicine
      Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai,
      China.
FAU - Fu, Lixin
AU  - Fu L
AD  - First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,
      Tianjin, China.
FAU - Li, Ning
AU  - Li N
AD  - West China Hospital of Sichuan University, Chengdu, China.
FAU - Lu, Yonghui
AU  - Lu Y
AD  - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Su, Tongsheng
AU  - Su T
AD  - Shaanxi Province Hospital of Traditional Chinese Medicine, Xi'an, China.
FAU - Sun, Jianhua
AU  - Sun J
AD  - Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, China.
FAU - Wang, Jie
AU  - Wang J
AD  - Shanxi Hospital of Integrated Traditional and Western Medicine, Taiyuan, China.
FAU - Yue, Zenghui
AU  - Yue Z
AD  - Hengyang Hospital Affiliated to Hunan University of Chinese Medicine, Hengyang,
      China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
FAU - Zhao, Jiping
AU  - Zhao J
AD  - Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,
      Beijing, China.
FAU - Zhou, Zhongyu
AU  - Zhou Z
AD  - Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
FAU - Wu, Jiani
AU  - Wu J
AD  - Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Zhou, Kehua
AU  - Zhou K
AD  - Daemen College Physical Therapy Wound Care Clinic, Daemen College, Amherst, New
      York.
FAU - Ai, Yanke
AU  - Ai Y
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese
      Medical Sciences, Beijing, China.
FAU - Zhou, Jing
AU  - Zhou J
AD  - Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Pang, Ran
AU  - Pang R
AD  - Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Wang, Yang
AU  - Wang Y
AD  - Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Qin, Zongshi
AU  - Qin Z
AD  - Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Yan, Shiyan
AU  - Yan S
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese
      Medical Sciences, Beijing, China.
FAU - Li, Hongjiao
AU  - Li H
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese
      Medical Sciences, Beijing, China.
FAU - Luo, Lin
AU  - Luo L
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese
      Medical Sciences, Beijing, China.
FAU - Liu, Baoyan
AU  - Liu B
AD  - Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT01784172
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - AIM
SB  - IM
CIN - JAMA. 2017 Jun 27;317(24):2489-2490. PMID: 28654992
MH  - Acupuncture Points
MH  - Adult
MH  - Aged
MH  - China
MH  - Electroacupuncture/adverse effects/*methods/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lumbosacral Region
MH  - Middle Aged
MH  - Time Factors
MH  - Treatment Outcome
MH  - Urinary Incontinence, Stress/epidemiology/*therapy
EDAT- 2017/06/28 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/28 06:00
AID - 2633916 [pii]
AID - 10.1001/jama.2017.7220 [doi]
PST - ppublish
SO  - JAMA. 2017 Jun 27;317(24):2493-2501. doi: 10.1001/jama.2017.7220.