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Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma.

Abstract Hepatocellular carcinoma is third leading cause of cancer-related death globally. Long non-coding RNA plasmacytoma variant translocation 1 has been reported to be dysregulated and plays a crucial role in various cancers. In this study, we investigated the interactions between plasmacytoma variant translocation 1 and miR-186-5p in the progression of hepatocellular carcinoma and explored the functional significance of plasmacytoma variant translocation 1. It was determined that plasmacytoma variant translocation 1 was significantly higher, while miR-186-5p was statistically lower in the hepatocellular carcinoma tissues than that in the adjacent normal tissues. Using gain-of-function and loss-of-function methods, our results revealed that plasmacytoma variant translocation 1 affected hepatocellular carcinoma cells proliferation, invasion, and migration. It was found that there was direct interaction between miR-186-5p and the binding site of plasmacytoma variant translocation 1 by performing dual-luciferase assay and RNA immunoprecipitation assay. Furthermore, it was identified that plasmacytoma variant translocation 1 regulated the expression of the miR-186-5p target gene, yes-associated protein 1. Taken together, plasmacytoma variant translocation 1 served as an endogenous sponge for miR-186-5p to reduce its inhibiting effect on yes-associated protein 1 and thus promoted the tumorigenesis of hepatocellular carcinoma.
PMID
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Authors

Mayor MeshTerms
Keywords

Hepatocellular carcinoma

competing endogenous RNA

endogenous sponge

miR-186-5p

plasmacytoma variant translocation 1

yes-associated protein 1

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28656879
OWN - NLM
STAT- MEDLINE
DA  - 20170628
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to
      promote the tumorigenesis and metastasis of hepatocellular carcinoma.
PG  - 1010428317705338
LID - 10.1177/1010428317705338 [doi]
AB  - Hepatocellular carcinoma is third leading cause of cancer-related death globally.
      Long non-coding RNA plasmacytoma variant translocation 1 has been reported to be 
      dysregulated and plays a crucial role in various cancers. In this study, we
      investigated the interactions between plasmacytoma variant translocation 1 and
      miR-186-5p in the progression of hepatocellular carcinoma and explored the
      functional significance of plasmacytoma variant translocation 1. It was
      determined that plasmacytoma variant translocation 1 was significantly higher,
      while miR-186-5p was statistically lower in the hepatocellular carcinoma tissues 
      than that in the adjacent normal tissues. Using gain-of-function and
      loss-of-function methods, our results revealed that plasmacytoma variant
      translocation 1 affected hepatocellular carcinoma cells proliferation, invasion, 
      and migration. It was found that there was direct interaction between miR-186-5p 
      and the binding site of plasmacytoma variant translocation 1 by performing
      dual-luciferase assay and RNA immunoprecipitation assay. Furthermore, it was
      identified that plasmacytoma variant translocation 1 regulated the expression of 
      the miR-186-5p target gene, yes-associated protein 1. Taken together,
      plasmacytoma variant translocation 1 served as an endogenous sponge for
      miR-186-5p to reduce its inhibiting effect on yes-associated protein 1 and thus
      promoted the tumorigenesis of hepatocellular carcinoma.
FAU - Lan, Tian
AU  - Lan T
AD  - 1 Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University,
      Wuhan, P.R. China.
FAU - Yan, Xia
AU  - Yan X
AD  - 2 Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, P.R.
      China.
FAU - Li, Zhuo
AU  - Li Z
AD  - 3 Department of Pediatric Surgery, People's Hospital of Nanshan District,
      Shenzhen, P.R. China.
FAU - Xu, Xin
AU  - Xu X
AD  - 4 Department of Digestion, Zhongnan Hospital of Wuhan University, Wuhan, P.R.
      China.
FAU - Mao, Qi
AU  - Mao Q
AD  - 5 Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, P.R.
      China.
FAU - Ma, Weijie
AU  - Ma W
AD  - 1 Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University,
      Wuhan, P.R. China.
FAU - Hong, Zhenfei
AU  - Hong Z
AD  - 1 Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University,
      Wuhan, P.R. China.
FAU - Chen, Xi
AU  - Chen X
AD  - 1 Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University,
      Wuhan, P.R. China.
FAU - Yuan, Yufeng
AU  - Yuan Y
AD  - 1 Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University,
      Wuhan, P.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MIRN186 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (PVT1 long-non-coding RNA, human)
RN  - 0 (Phosphoproteins)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (YAP1 (Yes-associated) protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*biosynthesis/genetics
MH  - Adult
MH  - Aged
MH  - Binding Sites
MH  - Carcinogenesis/genetics
MH  - Carcinoma, Hepatocellular/*genetics/pathology
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - DNA-Binding Proteins/genetics
MH  - Disease Progression
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Liver Neoplasms/*genetics/pathology
MH  - Male
MH  - MicroRNAs/*genetics/metabolism
MH  - Middle Aged
MH  - Neoplasm Invasiveness/genetics
MH  - Neoplasm Metastasis
MH  - Phosphoproteins/*biosynthesis/genetics
MH  - RNA, Long Noncoding/*genetics/metabolism
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - competing endogenous RNA
OT  - endogenous sponge
OT  - miR-186-5p
OT  - plasmacytoma variant translocation 1
OT  - yes-associated protein 1
EDAT- 2017/06/29 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/29 06:00
AID - 10.1177/1010428317705338 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317705338. doi: 10.1177/1010428317705338.