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Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances.

Abstract Circular RNAs are new type of endogenous RNAs, which play an important role in the regulation of gene expression and indicate a great capacity in clinical diagnosis and treatments of diseases. However, the role of circular RNAs in gastric cancer remains unknown. In this study, we chose hsa_circ_0006633 as the target circular RNA and measured its levels in human gastric cancer tissues, plasma, and gastric cell lines by real-time quantitative reverse transcription polymerase chain reaction. Hsa_circ_0006633 levels at multiple stages of gastric tumorigenesis were then explored, and its relationships with clinicopathological features were analyzed as well. We found that the expression levels of hsa_circ_0006633 in four gastric cancer cell lines, HGC-27, SGC-7901, MGC-803, and AGS, were downregulated than those in normal gastric mucosal epithelial cell line GES-1. Then, we further detected that it was downregulated in 79.2% (76/96) gastric cancer tissues compared with the adjacent non-tumorous tissues. The lower expression of hsa_circ_0006633 was associated with cancer distal metastasis ( p = 0.037) and tissue carcinoembryonic antigen level ( p = 0.041). In addition, hsa_circ_0006633 expression was significantly decreased in gastritis and dysplasia tissues comparing with the healthy control. Moreover, plasma hsa_circ_0006633 levels were significantly increased in gastric cancer compared with healthy control. Our data imply that hsa_circ_0006633 may play an important role in gastric carcinogenesis and is also a potential biomarker for screening gastric cancer.
PMID
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Authors

Mayor MeshTerms
Keywords

Gastric cancer

Hsa_circ_0006633

circular RNA

clinical significance

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28656881
OWN - NLM
STAT- In-Process
DA  - 20170628
LR  - 20170628
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Low expression of hsa_circ_0006633 in human gastric cancer and its clinical
      significances.
PG  - 1010428317704175
LID - 10.1177/1010428317704175 [doi]
AB  - Circular RNAs are new type of endogenous RNAs, which play an important role in
      the regulation of gene expression and indicate a great capacity in clinical
      diagnosis and treatments of diseases. However, the role of circular RNAs in
      gastric cancer remains unknown. In this study, we chose hsa_circ_0006633 as the
      target circular RNA and measured its levels in human gastric cancer tissues,
      plasma, and gastric cell lines by real-time quantitative reverse transcription
      polymerase chain reaction. Hsa_circ_0006633 levels at multiple stages of gastric 
      tumorigenesis were then explored, and its relationships with clinicopathological 
      features were analyzed as well. We found that the expression levels of
      hsa_circ_0006633 in four gastric cancer cell lines, HGC-27, SGC-7901, MGC-803,
      and AGS, were downregulated than those in normal gastric mucosal epithelial cell 
      line GES-1. Then, we further detected that it was downregulated in 79.2% (76/96) 
      gastric cancer tissues compared with the adjacent non-tumorous tissues. The lower
      expression of hsa_circ_0006633 was associated with cancer distal metastasis ( p =
      0.037) and tissue carcinoembryonic antigen level ( p = 0.041). In addition,
      hsa_circ_0006633 expression was significantly decreased in gastritis and
      dysplasia tissues comparing with the healthy control. Moreover, plasma
      hsa_circ_0006633 levels were significantly increased in gastric cancer compared
      with healthy control. Our data imply that hsa_circ_0006633 may play an important 
      role in gastric carcinogenesis and is also a potential biomarker for screening
      gastric cancer.
FAU - Lu, Rongdan
AU  - Lu R
AD  - 1 Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of
      Pathophysiology, Ningbo University School of Medicine, Ningbo, China.
AD  - 2 Department of Gastroenterology, The Affiliated Hospital of Ningbo University
      School of Medicine, Ningbo, China.
FAU - Shao, Yongfu
AU  - Shao Y
AD  - 2 Department of Gastroenterology, The Affiliated Hospital of Ningbo University
      School of Medicine, Ningbo, China.
FAU - Ye, Guoliang
AU  - Ye G
AD  - 2 Department of Gastroenterology, The Affiliated Hospital of Ningbo University
      School of Medicine, Ningbo, China.
FAU - Xiao, Bingxiu
AU  - Xiao B
AD  - 1 Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of
      Pathophysiology, Ningbo University School of Medicine, Ningbo, China.
FAU - Guo, Junming
AU  - Guo J
AD  - 1 Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of
      Pathophysiology, Ningbo University School of Medicine, Ningbo, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
OTO - NOTNLM
OT  - Gastric cancer
OT  - Hsa_circ_0006633
OT  - circular RNA
OT  - clinical significance
EDAT- 2017/06/29 06:00
MHDA- 2017/06/29 06:00
CRDT- 2017/06/29 06:00
AID - 10.1177/1010428317704175 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317704175. doi: 10.1177/1010428317704175.