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Leptospira diversity in animals and humans in Tahiti, French Polynesia.

Abstract Leptospirosis is a highly endemic bacterial zoonosis in French Polynesia (FP). Nevertheless, data on the epidemiology of leptospirosis in FP are scarce. We conducted molecular studies on Leptospira isolated from humans and the potential main animal reservoirs in order to identify the most likely sources for human infection.
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Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28658269
OWN - NLM
STAT- Publisher
DA  - 20170628
LR  - 20170628
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 6
DP  - 2017 Jun 28
TI  - Leptospira diversity in animals and humans in Tahiti, French Polynesia.
PG  - e0005676
LID - 10.1371/journal.pntd.0005676 [doi]
AB  - BACKGROUND: Leptospirosis is a highly endemic bacterial zoonosis in French
      Polynesia (FP). Nevertheless, data on the epidemiology of leptospirosis in FP are
      scarce. We conducted molecular studies on Leptospira isolated from humans and the
      potential main animal reservoirs in order to identify the most likely sources for
      human infection. METHODOLOGY/PRINCIPAL FINDINGS: Wild rats (n = 113), farm pigs
      (n = 181) and domestic dogs (n = 4) were screened for Leptospira infection in
      Tahiti, the most populated island in FP. Positive samples were genotyped and
      compared to Leptospira isolated from human cases throughout FP (n = 51), using
      secY, 16S and LipL32 sequencing, and MLST analysis. Leptospira DNA was detected
      in 20.4% of rats and 26.5% of pigs. We identified two Leptospira species and
      three sequence types (STs) in animals and humans: Leptospira interrogans ST140 in
      pigs only and L. interrogans ST17 and Leptospira borgpetersenii ST149 in humans
      and rats. Overall, L. interrogans was the dominant species and grouped into four 
      clades: one clade including a human case only, two clades including human cases
      and dogs, and one clade including human cases and rats. All except one pig sample
      showed a unique L. interrogans (secY) genotype distinct from those isolated from 
      humans, rats and dogs. Moreover, LipL32 sequencing allowed the detection of an
      additional Leptospira genotype in pigs, clearly distinct from the previous ones. 
      CONCLUSIONS/SIGNIFICANCE: Our data confirm rats as a major potential source for
      human leptospirosis in FP. By contrast to what was expected, farm pigs did not
      seem to be a major reservoir for the Leptospira genotypes identified in human
      patients. Thus, further investigations will be required to determine their
      significance in leptospirosis transmission in FP.
FAU - Guernier, Vanina
AU  - Guernier V
AUID- ORCID: http://orcid.org/0000-0002-0960-3874
AD  - Institut Louis Malarde, Papeete, Tahiti, French Polynesia.
AD  - Australian Institute for Tropical Health and Medicine (AITHM), JCU, Townsville,
      Australia.
FAU - Richard, Vaea
AU  - Richard V
AD  - Institut Louis Malarde, Papeete, Tahiti, French Polynesia.
FAU - Nhan, Tuxuan
AU  - Nhan T
AD  - Institut Louis Malarde, Papeete, Tahiti, French Polynesia.
FAU - Rouault, Eline
AU  - Rouault E
AD  - Institut Louis Malarde, Papeete, Tahiti, French Polynesia.
FAU - Tessier, Anita
AU  - Tessier A
AD  - Institut Louis Malarde, Papeete, Tahiti, French Polynesia.
FAU - Musso, Didier
AU  - Musso D
AD  - Institut Louis Malarde, Papeete, Tahiti, French Polynesia.
LA  - eng
PT  - Journal Article
DEP - 20170628
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
EDAT- 2017/06/29 06:00
MHDA- 2017/06/29 06:00
CRDT- 2017/06/29 06:00
PHST- 2016/12/30 [received]
PHST- 2017/06/02 [accepted]
AID - 10.1371/journal.pntd.0005676 [doi]
AID - PNTD-D-16-02300 [pii]
PST - aheadofprint
SO  - PLoS Negl Trop Dis. 2017 Jun 28;11(6):e0005676. doi:
      10.1371/journal.pntd.0005676.

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