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Predictors of Hepatitis B Surface Antigen Titers two decades after vaccination in a cohort of students and post-graduates of the Medical School at the University of Palermo, Italy.

Abstract <b>Introduction and objective.</b> The introduction of a vaccine against hepatitis B virus (HBV) for newborn babies in Italy in 1991, extended to 12-year-old children for the first 12 years of application, has been a major achievement in terms of the prevention of HBV infection. The objective of this study was to analyse the long-term immunogenicity and effectiveness of HBV vaccination among healthcare students with different working seniorities. <b>Materials and method.</b> A cross-sectional observational study of undergraduate and postgraduate students attending the Medical School of the University of Palermo was conducted from January 2014 - July 2016. HBV serum markers were performed with commercial chemiluminescence assays. Categorical variables were analyzed using the chi-square test (Mantel-Haenszel), whereas means were compared by using the Student's t test. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were also calculated by a multivariable logistic regression, using a model constructed to examine predictors of anti-HBs titer above 10 mIU/mL, assumed as protective. <b>Results.</b> Of the 2,114 subjects evaluated - all vaccinated at infancy or at the age of 12 years and were HBsAg/anti-HBc negative - 806 (38.1%) had an anti-HBs titre <10 IU/L. The latter were younger, more likely to be attending a healthcare profession school (i.e., nursing and midwifery), than a medical postgraduate level school, and more likely to have been vaccinated in infancy (p <0.001, 95% CI 2.63-5.26, adjusted OR 3.70). <b>Conclusion.</b> The results of the study suggest that assessment of HBV serum markers in workers potentially exposed to hospital infections is useful for identifying small numbers of unvaccinated subjects, or vaccinated subjects with low antibody titre, all of whom should be referred to a booster series of vaccinations.
PMID
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Authors

Mayor MeshTerms
Keywords

Anti-HBs titre

HBV infection

HBV vaccination

Healthcare students

postgraduate medical students

Journal Title annals of agricultural and environmental medicine : aaem
Publication Year Start




PMID- 28664713
OWN - NLM
STAT- MEDLINE
DA  - 20170630
DCOM- 20170710
LR  - 20170713
IS  - 1898-2263 (Electronic)
IS  - 1232-1966 (Linking)
VI  - 24
IP  - 2
DP  - 2017 Jun 12
TI  - Predictors of Hepatitis B Surface Antigen Titers two decades after vaccination in
      a cohort of students and post-graduates of the Medical School at the University
      of Palermo, Italy.
PG  - 303-306
LID - 74716 [pii]
AB  - &lt;b&gt;Introduction and objective.&lt;/b&gt; The introduction of a vaccine against
      hepatitis B virus (HBV) for newborn babies in Italy in 1991, extended to
      12-year-old children for the first 12 years of application, has been a major
      achievement in terms of the prevention of HBV infection. The objective of this
      study was to analyse the long-term immunogenicity and effectiveness of HBV
      vaccination among healthcare students with different working seniorities.
      &lt;b&gt;Materials and method.&lt;/b&gt; A cross-sectional observational study of
      undergraduate and postgraduate students attending the Medical School of the
      University of Palermo was conducted from January 2014 - July 2016. HBV serum
      markers were performed with commercial chemiluminescence assays. Categorical
      variables were analyzed using the chi-square test (Mantel-Haenszel), whereas
      means were compared by using the Student's t test. Adjusted odds ratios (ORs) and
      95% confidence intervals (CIs) were also calculated by a multivariable logistic
      regression, using a model constructed to examine predictors of anti-HBs titer
      above 10 mIU/mL, assumed as protective. &lt;b&gt;Results.&lt;/b&gt; Of the 2,114 subjects
      evaluated - all vaccinated at infancy or at the age of 12 years and were
      HBsAg/anti-HBc negative - 806 (38.1%) had an anti-HBs titre &lt;10 IU/L. The latter 
      were younger, more likely to be attending a healthcare profession school (i.e.,
      nursing and midwifery), than a medical postgraduate level school, and more likely
      to have been vaccinated in infancy (p &lt;0.001, 95% CI 2.63-5.26, adjusted OR
      3.70). &lt;b&gt;Conclusion.&lt;/b&gt; The results of the study suggest that assessment of HBV
      serum markers in workers potentially exposed to hospital infections is useful for
      identifying small numbers of unvaccinated subjects, or vaccinated subjects with
      low antibody titre, all of whom should be referred to a booster series of
      vaccinations.
FAU - Verso, M G
AU  - Verso MG
AD  - Department of Sciences for Health Promotion and Mother-Child Care 'G.
      D'Alessandro', Occupational Health Section, University of Palermo, via del Vespro
      143, 90127 Palermo, Italy. [email protected]
FAU - Lo Cascio, N
AU  - Lo Cascio N
AD  - Health Workers Medical Service - University Hospital Policlinico 'Paolo
      Giaccone', via del Vespro 143, 90127 Palermo, Italy.
FAU - Noto Laddeca, E
AU  - Noto Laddeca E
AD  - Unit of Occupational Health - University Hospital Policlinico 'Paolo Giaccone',
      via del Vespro 143, 90127 Palermo, Italy Italy.
FAU - Amodio, E
AU  - Amodio E
AD  - Epidemiology and Programming Service - Department of Planning, Purchasing and
      Control ATS Brianza, Monza, Italy.
FAU - Currieri, M
AU  - Currieri M
AD  - School of Specialization in Occupational Health, School of Medicine, University
      of Palermo, Italy.
FAU - Giammanco, G
AU  - Giammanco G
AD  - Department of Sciences for Health Promotion and Mother-Child Care 'G.
      D'Alessandro', Microbiology Section, University of Palermo, via del Vespro 129,
      90127 Palermo, Italy.
FAU - Ferraro, D
AU  - Ferraro D
AD  - Department of Sciences for Health Promotion and Mother-Child Care 'G.
      D'Alessandro', Microbiology Section, University of Palermo, via del Vespro 129,
      90127 Palermo, Italy.
FAU - De Grazia, S
AU  - De Grazia S
AD  - Department of Sciences for Health Promotion and Mother-Child Care 'G.
      D'Alessandro', Microbiology Section, University of Palermo, via del Vespro 129,
      90127 Palermo, Italy.
FAU - Picciotto, D
AU  - Picciotto D
AD  - Department of Sciences for Health Promotion and Mother-Child Care 'G.
      D'Alessandro', Occupational Health Section, University of Palermo, via del Vespro
      143, 90127 Palermo, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Poland
TA  - Ann Agric Environ Med
JT  - Annals of agricultural and environmental medicine : AAEM
JID - 9500166
RN  - 0 (Biomarkers)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Child
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Hepatitis B/immunology/*prevention &amp; control/virology
MH  - Hepatitis B Antibodies
MH  - Hepatitis B Surface Antigens/administration &amp; dosage/*immunology
MH  - Hepatitis B Vaccines/administration &amp; dosage/*immunology
MH  - Hepatitis B virus/genetics/*immunology
MH  - Humans
MH  - Male
MH  - Schools, Medical
MH  - Students
MH  - Students, Medical
MH  - Young Adult
OTO - NOTNLM
OT  - Anti-HBs titre
OT  - HBV infection
OT  - HBV vaccination
OT  - Healthcare students
OT  - postgraduate medical students
EDAT- 2017/07/01 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/07/01 06:00
AID - 74716 [pii]
PST - ppublish
SO  - Ann Agric Environ Med. 2017 Jun 12;24(2):303-306.