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Evolution of Bovine viral diarrhea virus in Canada from 1997 to 2013.

Abstract Bovine viral diarrhea virus (BVDV) is a rapidly evolving, single-stranded RNA virus and a production limiting pathogen of cattle worldwide. 79 viral isolates collected between 1997 and 2013 in Canada were subjected to next-generation sequencing. Bayesian phylogenetics was used to assess the evolution of this virus. A mean substitution rate of 1.4×10(-3) substitutions/site/year was found across both BVDV1 and BVDV2. Evolutionary rates in the E2 gene were slightly faster than other regions. We also identified population structures below the sub-genotype level that likely have phenotypic implications. Two distinct clusters within BVDV2a are present and can be differentiated, in part, by a tyrosine to isoleucine mutation at position 963 in the E2 protein, a position implicated in the antigenicity of BVDV1 isolates. Distinct clustering within all sub-genotypes, particularly BVDV2a, is apparent and could lead to new levels of genotypic classification. Continuous monitoring of emerging variants is therefore necessary.
PMID
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Authors

Mayor MeshTerms
Keywords

Bovine viral diarrhea virus

Canada

Evolution

Next-generation sequencing

Phylogenetics

ssRNA viruses

Journal Title virology
Publication Year Start




PMID- 28668732
OWN - NLM
STAT- Publisher
DA  - 20170702
LR  - 20170702
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 509
DP  - 2017 Jun 29
TI  - Evolution of Bovine viral diarrhea virus in Canada from 1997 to 2013.
PG  - 232-238
LID - S0042-6822(17)30201-5 [pii]
LID - 10.1016/j.virol.2017.06.024 [doi]
AB  - Bovine viral diarrhea virus (BVDV) is a rapidly evolving, single-stranded RNA
      virus and a production limiting pathogen of cattle worldwide. 79 viral isolates
      collected between 1997 and 2013 in Canada were subjected to next-generation
      sequencing. Bayesian phylogenetics was used to assess the evolution of this
      virus. A mean substitution rate of 1.4x10-3 substitutions/site/year was found
      across both BVDV1 and BVDV2. Evolutionary rates in the E2 gene were slightly
      faster than other regions. We also identified population structures below the
      sub-genotype level that likely have phenotypic implications. Two distinct
      clusters within BVDV2a are present and can be differentiated, in part, by a
      tyrosine to isoleucine mutation at position 963 in the E2 protein, a position
      implicated in the antigenicity of BVDV1 isolates. Distinct clustering within all 
      sub-genotypes, particularly BVDV2a, is apparent and could lead to new levels of
      genotypic classification. Continuous monitoring of emerging variants is therefore
      necessary.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Chernick, Adam
AU  - Chernick A
AD  - Ecosystem and Public Health, Faculty of Veterinary Medicine, University of
      Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 1N4, Canada. Electronic address:
      [email protected]
FAU - van der Meer, Frank
AU  - van der Meer F
AD  - Ecosystem and Public Health, Faculty of Veterinary Medicine, University of
      Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 1N4, Canada. Electronic address:
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170629
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
OTO - NOTNLM
OT  - Bovine viral diarrhea virus
OT  - Canada
OT  - Evolution
OT  - Next-generation sequencing
OT  - Phylogenetics
OT  - ssRNA viruses
EDAT- 2017/07/03 06:00
MHDA- 2017/07/03 06:00
CRDT- 2017/07/03 06:00
PHST- 2017/04/08 [received]
PHST- 2017/06/20 [revised]
PHST- 2017/06/21 [accepted]
AID - S0042-6822(17)30201-5 [pii]
AID - 10.1016/j.virol.2017.06.024 [doi]
PST - aheadofprint
SO  - Virology. 2017 Jun 29;509:232-238. doi: 10.1016/j.virol.2017.06.024.