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Establishment of rat models with altered anterior guidance and observation of histological changes in temporomandibular joint synovium.

Abstract This study aims to establish a stable animal model with altered anterior guidance and investigate histological changes on temporomandibular joint (TMJ) synovium in rats.
PMID
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Authors

Mayor MeshTerms

Synovial Membrane

Temporomandibular Joint

Temporomandibular Joint Disorders

Keywords

anterior guidance deficiency

inclination of anterior guidance

synovial membrane

temporomandibular joint

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start

 



PMID- 28675008
OWN - NLM
STAT- MEDLINE
DA  - 20170704
DCOM- 20170807
LR  - 20170807
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 3
DP  - 2017 Jun 01
TI  - [Establishment of rat models with altered anterior guidance and observation of
      histological changes in temporomandibular joint synovium].
PG  - 253-257
LID - 10.7518/hxkq.2017.03.005 [doi]
AB  - OBJECTIVE: This study aims to establish a stable animal model with altered
      anterior guidance and investigate histological changes on temporomandibular joint
      (TMJ) synovium in rats. METHODS: Thirty-two rats were divided into four groups,
      namely, control group, anterior-guidance-deficient group (T1), and anterior
      guidance inclined up to 15 degree (T2) and 30 degree (T3) groups. Metal crowns
      that add 15 and 30 degrees to the palatal side were cemented to the incisors of
      maxilla to increase the inclination of anterior guidance. The low-speed diamond
      wheel shorts for both upper and lower incisors of rats were applied to avoid
      contact between anterior teeth in all direction, thus establishing an anterior
      guidance deletion model. TMJ joints on one side of two animals in each group were
      harvested after 3, 7, 14, and 28 days. Pathological changes were investigated in 
      the TMJ synovium using hematoxylin-eosin (HE) staining. RESULTS: The weight of T1
      decreased briefly at first, and then increased slightly (P<0.05). The weight of
      T3 obviously reduced and then slowly increased, but remained below the initial
      weight (P<0.05). T3 manifested obvious synovial lining proliferation and vascular
      dilation (P<0.05). CONCLUSIONS: The rat model of anterior guidance inclined up to
      30 degree could imitate the pathological features of TMJ synovium with excessive 
      increase in anterior guidance. A higher inclination of anterior guidance might
      cause more damage of TMJ synovium. The effect of anterior guidance deletion on
      TMJ synovium is yet to be determined..
FAU - Yuxuan, Li
AU  - Yuxuan L
AD  - Dept. of Prothodontics, Stomatology Hospital of Xi'an Jiao Tong University, Xi'an
      710004, China.
FAU - Tong, Zhai
AU  - Tong Z
AD  - Dept. of Prothodontics, Stomatology Hospital of Xi'an Jiao Tong University, Xi'an
      710004, China.
FAU - Wenhong, Tan
AU  - Wenhong T
AD  - Dept. of Prothodontics, Stomatology Hospital of Xi'an Jiao Tong University, Xi'an
      710004, China.
FAU - Lekang, Bai
AU  - Lekang B
AD  - Dept. of Prothodontics, Stomatology Hospital of Xi'an Jiao Tong University, Xi'an
      710004, China.
FAU - Min, Xiao
AU  - Min X
AD  - Dept. of Prothodontics, Stomatology Hospital of Xi'an Jiao Tong University, Xi'an
      710004, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
SB  - D
SB  - IM
MH  - Animals
MH  - Dental Cementum
MH  - Disease Models, Animal
MH  - Incisor
MH  - Maxilla
MH  - Rats
MH  - *Synovial Membrane
MH  - *Temporomandibular Joint
MH  - *Temporomandibular Joint Disorders
OTO - NOTNLM
OT  - anterior guidance deficiency
OT  - inclination of anterior guidance
OT  - synovial membrane
OT  - temporomandibular joint
EDAT- 2017/07/05 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/05 06:00
AID - 10.7518/hxkq.2017.03.005 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun 1;35(3):253-257. doi:
      10.7518/hxkq.2017.03.005.