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Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on periodontitis by regulating macrophage differentiation.

Abstract To explore the therapeutic effect of enhancer of Zeste homolog 2 (EZH2) inhibitor GSK343 on periodontitis by regulating microphage differentiation.
PMID
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Authors

Mayor MeshTerms
Keywords

epigenetic

macrophage

microenvironment

periodontitis

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start




PMID- 28675010
OWN - NLM
STAT- In-Process
DA  - 20170704
LR  - 20170704
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 3
DP  - 2017 Jun 01
TI  - [Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on
      periodontitis by regulating macrophage differentiation].
PG  - 264-268
LID - 10.7518/hxkq.2017.03.007 [doi]
AB  - OBJECTIVE: To explore the therapeutic effect of enhancer of Zeste homolog 2
      (EZH2) inhibitor GSK343 on periodontitis by regulating microphage
      differentiation. METHODS: Macrophage RAW264.7 cells were divided into the blank
      (A group), control (B group), lipopolysaccharide (LPS) stimulation (C group), and
      LPS+GSK343 (D group) groups. Phenotype transformations was determined through
      Western blot analysis and enzyme-linked immunosorbent assay by detecting the
      differentiation of phenotypic biological markers, including tumor necrosis
      factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin-10 
      (IL-10), and Arginase-1 (Arg-1). Metergasis was identified by performing a
      phagocytosis test on Escherichia coli (E. coli). RESULTS: Macrophage RAW264.7
      cells produced classical phenotypic biomarkers (M1) TNF-alpha and iNOS under LPS 
      stimulation. The expression levels of IL-10 and Arg-1 increased after adding
      GSK343 into the culture medium. GSK343 also induced the conversion of M1
      macrophages into M2 macrophages. Macrophage RAW264.7 cells exerted a phagocytic
      effect on E. coli, and this effect was enhanced after adding LPS into the culture
      medium. GSK343 regulated the macrophage RAW264.7 phagocytosis of E. coli.
      CONCLUSIONS: GSK343 possibly participates in the regulation of macrophage
      differentiation and, consequently, in the latent treatment of periodontitis.
FAU - Zhongchao, Wang
AU  - Zhongchao W
AD  - Orofacial Reconstruction and Regeneration Laboratory, Southwest Medical
      University, Luzhou 646000, China;Dept. of Oral Medicine, The Affiliated
      Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.
FAU - Liyuan, Fan
AU  - Liyuan F
AD  - Orofacial Reconstruction and Regeneration Laboratory, Southwest Medical
      University, Luzhou 646000, China;Dept. of Prosthodontics, The Affiliated
      Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.
FAU - Dan, Tan
AU  - Dan T
AD  - Orofacial Reconstruction and Regeneration Laboratory, Southwest Medical
      University, Luzhou 646000, China;Dept. of Oral Medicine, The Affiliated
      Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.
FAU - Cong, Zhou
AU  - Cong Z
AD  - Orofacial Reconstruction and Regeneration Laboratory, Southwest Medical
      University, Luzhou 646000, China;Dept. of Oral Medicine, The Affiliated
      Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.
FAU - Shijun, Luo
AU  - Shijun L
AD  - Orofacial Reconstruction and Regeneration Laboratory, Southwest Medical
      University, Luzhou 646000, China;Dept. of Prosthodontics, The Affiliated
      Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
OTO - NOTNLM
OT  - epigenetic
OT  - macrophage
OT  - microenvironment
OT  - periodontitis
EDAT- 2017/07/05 06:00
MHDA- 2017/07/05 06:00
CRDT- 2017/07/05 06:00
AID - 10.7518/hxkq.2017.03.007 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun 1;35(3):264-268. doi:
      10.7518/hxkq.2017.03.007.