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Soluble programmed death-1 and soluble programmed death ligand 1 protein expression and immune status in patients with recurrent aphthous ulcer.

Abstract This study aims to investigate the possible role and significance of soluble programmed death-1 (sPD-1)  /soluble programmed death ligand 1 (sPD-L1) in the immune pathogeneses of recurrent aphthous ulcer (RAU).
PMID
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Authors

Mayor MeshTerms
Keywords

immune

recurrent aphthous ulcer

soluble programmed death ligand 1

soluble programmed death-1

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start



 

PMID- 28675014
OWN - NLM
STAT- In-Process
DA  - 20170704
LR  - 20170704
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 3
DP  - 2017 Jun 01
TI  - [Soluble programmed death-1 and soluble programmed death ligand 1 protein
      expression and immune status in patients with recurrent aphthous ulcer].
PG  - 286-290
LID - 10.7518/hxkq.2017.03.011 [doi]
AB  - OBJECTIVE: This study aims to investigate the possible role and significance of
      soluble programmed death-1 (sPD-1) /soluble programmed death ligand 1 (sPD-L1) in
      the immune pathogeneses of recurrent aphthous ulcer (RAU). METHODS: A total of 30
      RAU cases (18 cases of minor RAU, 5 cases of major RAU, and 7 cases of
      herpetiform ulcers) were enrolled in this study. A total of 18 healthy people
      served as controls. Lymphocyte subsets (CD3(+), CD4(+), CD8(+), CD19(+), and
      CD16(+)+56(+)) were investigated by flow cytometric analysis. Humoral immunity
      (IgG, IgA, IgM, C3, and C4) was explored by nephelometry immunoassay. The sPD-1
      and sPD-L1 protein levels in the sera of RAU patients were investigated by
      enzyme-linked immunosorbent assay. The correlations of the sPD-1 and sPD-L1
      protein levels with the immune status and clinical characteristics of the RAU
      patients were analyzed by SPSS 19.0. RESULTS: The number of CD4+ T cells
      decreased and the levels of IgM antibodies increased in the RAU patients relative
      to those in the normal controls (P<0.05). The sPD-1 and sPD-L1 protein levels in 
      the RAU patients were significantly higher than those in the control group
      (P<0.05). Meanwhile, the sPD-1 and sPD-L1 protein levels in the patients with
      minor and major RAU were significantly higher than those in the control group
      (P<0.05). By contrast, no significant difference was found in the patients with
      herpetiform RAU (P>0.05). Positive correlations were noted between the sPD-1
      protein level and the CD19+ cell frequency or C4 level (r(1)=0.389, P(1)=0.034;
      r(2)=0.382, P(2)=0.037). CONCLUSIONS: Cellular immune hypofunction and humoral
      immunity disorders were found in the RAU patients. The PD-1/PD-L1 signaling
      pathway, which might be influenced by the involvement of sPD-1 and sPD-L1
      proteins to a certain extent, may play some roles in the immune pathogenesis of
      RAU.
FAU - Nan, Jiang
AU  - Nan J
AD  - Dept. of Periodontal and Oral Mucosal Diseases, The Affiliated Stomatological
      Hospital of Guizhou Medical University, Guiyang 550004, China.
FAU - Liang, Luo
AU  - Liang L
AD  - Dept. of Periodontal and Oral Mucosal Diseases, The Affiliated Stomatological
      Hospital of Guizhou Medical University, Guiyang 550004, China.
FAU - Li, Liu
AU  - Li L
AD  - Dept. of Periodontal and Oral Mucosal Diseases, The Affiliated Stomatological
      Hospital of Guizhou Medical University, Guiyang 550004, China.
FAU - Xiaoqin, Sun
AU  - Xiaoqin S
AD  - Dept. of Periodontal and Oral Mucosal Diseases, The Affiliated Stomatological
      Hospital of Guizhou Medical University, Guiyang 550004, China.
FAU - Xing, Jiang
AU  - Xing J
AD  - Dept. of Periodontal and Oral Mucosal Diseases, The Affiliated Stomatological
      Hospital of Guizhou Medical University, Guiyang 550004, China.
FAU - Yang, Cai
AU  - Yang C
AD  - Dept. of Periodontal and Oral Mucosal Diseases, The Affiliated Stomatological
      Hospital of Guizhou Medical University, Guiyang 550004, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
OTO - NOTNLM
OT  - immune
OT  - recurrent aphthous ulcer
OT  - soluble programmed death ligand 1
OT  - soluble programmed death-1
EDAT- 2017/07/05 06:00
MHDA- 2017/07/05 06:00
CRDT- 2017/07/05 06:00
AID - 10.7518/hxkq.2017.03.011 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun 1;35(3):286-290. doi:
      10.7518/hxkq.2017.03.011.