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Clinical significance of CD44 and CD133 expression in oral potentially malignant disorder and oral squamous cell carcinoma.

Abstract This study aims to investigate the expression and relationship of CD44 and CD133 in normal oral mucosa, oral potentially malignant disorder (OPMD), and oral squamous cell carcinoma (OSCC). This work also analyzes the relationship between such expression and clinical factors. This study intends to evaluate the clinical value of using CD44 and CD133 as indices to evaluate the carcinogenic potential of OPMD.
PMID
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Authors

Mayor MeshTerms

AC133 Antigen

Antigens, CD44

Carcinoma, Squamous Cell

Mouth Mucosa

Mouth Neoplasms

Keywords

CD133

CD44

clinical significance

oral potentially malignant disorder

oral squamous cell carcinoma

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start




PMID- 28675018
OWN - NLM
STAT- MEDLINE
DA  - 20170704
DCOM- 20170807
LR  - 20170807
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 3
DP  - 2017 Jun 01
TI  - [Clinical significance of CD44 and CD133 expression in oral potentially malignant
      disorder and oral squamous cell carcinoma].
PG  - 311-316
LID - 10.7518/hxkq.2017.03.015 [doi]
AB  - OBJECTIVE: This study aims to investigate the expression and relationship of CD44
      and CD133 in normal oral mucosa, oral potentially malignant disorder (OPMD), and 
      oral squamous cell carcinoma (OSCC). This work also analyzes the relationship
      between such expression and clinical factors. This study intends to evaluate the 
      clinical value of using CD44 and CD133 as indices to evaluate the carcinogenic
      potential of OPMD. METHODS: Clinical data from 60 patients with OPMD, 60 patients
      with OSCC, and 10 cases of normal oral mucosa were analyzed. Double
      immunohistochemical analysis was applied to investigate the expression of CD44
      and CD133 in paraffin sections of normal oral mucosa, OPMD, and OSCC tissues.
      Subsequently, the relationships between such expression and clinical factors were
      analyzed. RESULTS: The positive rates of CD44 expression in the normal oral
      mucosa, OPMD, and OSCC tissues were 100.00%, 96.67%, and 71.67% (P<0.05),
      respectively. Meanwhile, the positive rates of CD133 expression in the normal
      oral mucosa, OPMD, and OSCC tissues were 0.00%, 35.00%, and 63.33% (P<0.05),
      respectively. The expression of CD44 and CD133 was found to be correlated
      (P<0.05). Such expression was related to the clinical stages and lymphatic
      metastasis of OSCC (P<0.05). CONCLUSIONS: CD44 and CD133 can be used individually
      as clinical indices to evaluate the carcinogenic potential of OPMD..
FAU - Jiajia, Qi
AU  - Jiajia Q
AD  - School of Stomatology, Qingdao University, Qingdao 266000, China.
FAU - Yan, Sun
AU  - Yan S
AD  - School of Stomatology, Qingdao University, Qingdao 266000, China.
FAU - Changqing, Yuan
AU  - Changqing Y
AD  - Dept. of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao
      266000, China.
FAU - Wenjing, Jiang
AU  - Wenjing J
AD  - Dept. of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao
      266000, China.
FAU - Han, Zhao
AU  - Han Z
AD  - Dept. of Pathology, The Affiliated Hospital of Qingdao University, Qingdao
      266000, China.
FAU - Yuanpan, Cao
AU  - Yuanpan C
AD  - School of Stomatology, Qingdao University, Qingdao 266000, China.
FAU - Qiuyan, Liu
AU  - Qiuyan L
AD  - School of Stomatology, Qingdao University, Qingdao 266000, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
RN  - 0 (AC133 Antigen)
RN  - 0 (Antigens, CD44)
RN  - 0 (CD44 protein, human)
RN  - 0 (PROM1 protein, human)
SB  - D
SB  - IM
MH  - *AC133 Antigen
MH  - *Antigens, CD44
MH  - Carcinogenesis
MH  - *Carcinoma, Squamous Cell
MH  - Humans
MH  - Lymphatic Metastasis
MH  - *Mouth Mucosa
MH  - *Mouth Neoplasms
OTO - NOTNLM
OT  - CD133
OT  - CD44
OT  - clinical significance
OT  - oral potentially malignant disorder
OT  - oral squamous cell carcinoma
EDAT- 2017/07/05 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/05 06:00
AID - 10.7518/hxkq.2017.03.015 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun 1;35(3):311-316. doi:
      10.7518/hxkq.2017.03.015.