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Inhibitory effect and underlying mechanism of total saponins from Paris polyphylla var. yunnanensis on the proliferation of salivary adenoid cystic carcinoma ACC-83 cells.

Abstract To investigate the inhibitory effect and underlying mechanism of total saponins from Paris polyphylla var. yunnanensis on the proliferation of salivary adenoid cystic carcinoma ACC-83 cells.
PMID
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Authors

Mayor MeshTerms
Keywords

macrophage migration inhibitory factor

salivary adenoid cystic carcinoma

total saponins from Paris polyphylla var. yunnanensis

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start




PMID- 28675019
OWN - NLM
STAT- In-Process
DA  - 20170704
LR  - 20170704
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 3
DP  - 2017 Jun 01
TI  - [Inhibitory effect and underlying mechanism of total saponins from Paris
      polyphylla var. yunnanensis on the proliferation of salivary adenoid cystic
      carcinoma ACC-83 cells].
PG  - 317-321
LID - 10.7518/hxkq.2017.03.016 [doi]
AB  - OBJECTIVE: To investigate the inhibitory effect and underlying mechanism of total
      saponins from Paris polyphylla var. yunnanensis on the proliferation of salivary 
      adenoid cystic carcinoma ACC-83 cells. METHODS: In vitro cell culture was
      performed. The proliferation of ACC-83 cells treated with different
      concentrations (5, 10, 20, 40, 60, 80, 100 mug.mL(-)(1)) of total saponins from
      Paris polyphylla var. yunnanensis was observed using CCK-8 assay. Meanwhile, the 
      apoptosis of ACC-83 cells treated with different concentrations (25, 50, 100
      mug.mL(-)(1)) of the total saponins was observed using flow cytometry. The
      expression levels of macrophage migration inhibitory factor (MIF) and CD74 were
      measured using Western blot and reverse transcription-polymerase chain reaction. 
      RESULTS: The total saponins from Paris polyphylla var. yunnanensis induced
      apoptosis and expressed dose-effect relationship. ACC-83 cells expressed MIF and 
      CD74, and the total saponins suppressed MIF and CD74 expression in ACC-83 cells. 
      CONCLUSIONS: The total saponins from Paris polyphylla var. yunnanensis can
      significantly inhibit the proliferation, suppress MIF and CD74 expression, and
      promote apoptosis in ACC-83 cells. This study provides a theoretical basis for
      the treatment of salivary adenoid cystic carcinoma using Paris polyphylla var.
      yunnanensis..
FAU - Qiumin, He
AU  - Qiumin H
AD  - Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of
      Kunming Medical University, Kunming 650106, China.
FAU - Biao, Xu
AU  - Biao X
AD  - Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of
      Kunming Medical University, Kunming 650106, China.
FAU - Weihong, Wang
AU  - Weihong W
AD  - Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of
      Kunming Medical University, Kunming 650106, China.
FAU - Chongyun, Bao
AU  - Chongyun B
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral
      Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041,
      China.
FAU - Shaowei, Hu
AU  - Shaowei H
AD  - Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of
      Kunming Medical University, Kunming 650106, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
OTO - NOTNLM
OT  - macrophage migration inhibitory factor
OT  - salivary adenoid cystic carcinoma
OT  - total saponins from Paris polyphylla var. yunnanensis
EDAT- 2017/07/05 06:00
MHDA- 2017/07/05 06:00
CRDT- 2017/07/05 06:00
AID - 10.7518/hxkq.2017.03.016 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun 1;35(3):317-321. doi:
      10.7518/hxkq.2017.03.016.