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Tumor necrosis factor-α regulates the osteogenic differentiation of bone marrow mesenchymal stem cells in chronic periodontitis.

Abstract Bone marrow mesenchymal stem cells (BMSCs) and ideal adult stem cells for alveolar bone regeneration considerably help restore the structure and function of the periodontium and promote the healing of periodontal disease. Thus, BMSC features, especially the mechanism of osteogenic differentiation, has recently become a research hotspot. Tumor necrosis factor-α (TNF-α), which is the main factor in the periodontal inflammatory microenvironment, is directly related to the osteogenic differentiation of BMSCs. Exploring the TNF-α-regulated differentiation mechanism of BMSCs aids in the search for new treatment targets. Such investigation also promotes the development of stem cell therapy for periodontal diseases. This article aims to describe the potential of TNF-α in regulating the osteogenic differentiation of stem cells.
PMID
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Authors

Mayor MeshTerms
Keywords

bone marrow mesenchymal stem cells

chronic periodontitis

osteogenic differentiation

tumor necrosis factor-α

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start




PMID- 28675022
OWN - NLM
STAT- In-Process
DA  - 20170704
LR  - 20170704
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 3
DP  - 2017 Jun 01
TI  - [Tumor necrosis factor-alpha regulates the osteogenic differentiation of bone
      marrow mesenchymal stem cells in chronic periodontitis].
PG  - 334-338
LID - 10.7518/hxkq.2017.03.019 [doi]
AB  - Bone marrow mesenchymal stem cells (BMSCs) and ideal adult stem cells for
      alveolar bone regeneration considerably help restore the structure and function
      of the periodontium and promote the healing of periodontal disease. Thus, BMSC
      features, especially the mechanism of osteogenic differentiation, has recently
      become a research hotspot. Tumor necrosis factor-alpha (TNF-alpha), which is the 
      main factor in the periodontal inflammatory microenvironment, is directly related
      to the osteogenic differentiation of BMSCs. Exploring the TNF-alpha-regulated
      differentiation mechanism of BMSCs aids in the search for new treatment targets. 
      Such investigation also promotes the development of stem cell therapy for
      periodontal diseases. This article aims to describe the potential of TNF-alpha in
      regulating the osteogenic differentiation of stem cells.
FAU - Xiaoguang, Li
AU  - Xiaoguang L
AD  - Institution of Stomatology, The PLA General Hospital, Beijing 100853, China.
FAU - Yizhu, Wang
AU  - Yizhu W
AD  - Institution of Stomatology, The PLA General Hospital, Beijing 100853, China.
FAU - Bin, Guo
AU  - Bin G
AD  - Institution of Stomatology, The PLA General Hospital, Beijing 100853, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
OTO - NOTNLM
OT  - bone marrow mesenchymal stem cells
OT  - chronic periodontitis
OT  - osteogenic differentiation
OT  - tumor necrosis factor-alpha
EDAT- 2017/07/05 06:00
MHDA- 2017/07/05 06:00
CRDT- 2017/07/05 06:00
AID - 10.7518/hxkq.2017.03.019 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun 1;35(3):334-338. doi:
      10.7518/hxkq.2017.03.019.