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Cadherin switching induced by P120-catenin can promote the migration and invasion of oral squamous cell cancer cells.

Abstract The main goal is to investigate the role of P120-catenin (P120ctn) in cadherin switching, as well as migration and invasion, of oral squamous cell cancer (OSCC) cells.
PMID
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P120ctn may participate in epithelial-mesenchymal transition in OSCC.

Authors

Mayor MeshTerms

Cadherins

Carcinoma, Squamous Cell

Catenins

Mouth Neoplasms

Neoplasm Invasiveness

Keywords

P120-catenin

cadherin switching

oral squamous cell cancer

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start




PMID- 28682550
OWN - NLM
STAT- MEDLINE
DA  - 20170706
DCOM- 20170807
LR  - 20170807
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 2
DP  - 2017 Apr 01
TI  - [Cadherin switching induced by P120-catenin can promote the migration and
      invasion of oral squamous cell cancer cells].
PG  - 183-186
LID - 10.7518/hxkq.2017.02.014 [doi]
AB  - OBJECTIVE: The main goal is to investigate the role of P120-catenin (P120ctn) in 
      cadherin switching, as well as migration and invasion, of oral squamous cell
      cancer (OSCC) cells. METHODS: The plasmid pGFP-V-RS-P120ctn shRNA was used to
      transfect TSCCA cells and significantly reduce the expression of P120ctn in these
      cells. Real-time fluorescent quantitative polymerase chain reaction and Western
      blot were conducted to determine the mRNA and protein expression levels of
      P120ctn, E-cadherin (E-cad), and N-cadherin (N-cad). By contrast, the Transwell
      cell invasion and cell migration assay was used to determine the invasion and
      migration capacities before and after the transfection. RESULTS: After the
      plasmid pGFP-V-RS-P120ctn shRNA was transfected into the TSCCA cells, we found
      that as the P120ctn expression significantly decreased, E-cad mRNA and protein
      expression decreased significantly. Moreover, N-cad mRNA and protein expression
      increased significantly (P<0.05). Lastly, the cell migration and invasion
      capacities were augmented significantly (P<0.05). CONCLUSIONS: In OSCC cells,
      P120ctn may be involved in cadherin switching and promote metastasis and
      invasion.
FAU - Zhong, Chen
AU  - Zhong C
AD  - Dept. of Stomatology, Xiamen Medical College, Xiamen 361008, China.
FAU - Mei, Zhang
AU  - Mei Z
AD  - Dept. of Stomatology, Gaoqing People's Hospital in Shandong Province, Gaoqing
      256300, China.
FAU - Yong, Xu
AU  - Yong X
AD  - Dept. of Stomatology, Xiamen Medical College, Xiamen 361008, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
RN  - 0 (CDH1 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Catenins)
RN  - 0 (delta catenin)
SB  - D
SB  - IM
MH  - *Cadherins
MH  - *Carcinoma, Squamous Cell
MH  - *Catenins
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Humans
MH  - *Mouth Neoplasms
MH  - *Neoplasm Invasiveness
MH  - Neoplasm Metastasis
MH  - Transfection
OTO - NOTNLM
OT  - P120-catenin
OT  - cadherin switching
OT  - oral squamous cell cancer
EDAT- 2017/07/07 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/07 06:00
AID - 10.7518/hxkq.2017.02.014 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Apr 1;35(2):183-186. doi:
      10.7518/hxkq.2017.02.014.