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Effects of oral interventions on carotid artery in rats with chronic periodontitis for the detection of Porphyromonas gingivalis and the expression of C-reactive protein.

Abstract This study aimed to establish a SD rat model of chronic periodontitis (CP) merged with hyperlipidemia (HL), perform periodontal treatment, detect the expression of partial C-reactive protein (CRP) and Porphyromonas gingivalis (P. gingivalis) in the rat carotid artery, and explore the relationship between periodontitis and atherosclerosis.
PMID
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Authors

Mayor MeshTerms
Keywords

C-reactive protein

Porphyromonas gingivalis

hyperlipidemia

periodontal basic treatment

periodontitis

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start




PMID- 28682552
OWN - NLM
STAT- In-Process
DA  - 20170706
LR  - 20170706
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 2
DP  - 2017 Apr 01
TI  - [Effects of oral interventions on carotid artery in rats with chronic
      periodontitis for the detection of Porphyromonas gingivalis and the expression of
      C-reactive protein].
PG  - 192-197
LID - 10.7518/hxkq.2017.02.016 [doi]
AB  - OBJECTIVE: This study aimed to establish a SD rat model of chronic periodontitis 
      (CP) merged with hyperlipidemia (HL), perform periodontal treatment, detect the
      expression of partial C-reactive protein (CRP) and Porphyromonas gingivalis (P.
      gingivalis) in the rat carotid artery, and explore the relationship between
      periodontitis and atherosclerosis. METHODS: SD rats were randomly divided into
      three groups: control group (A), HL group (B), and CP+HL group (C). Group C rats 
      were divided into natural process group (C1), scaling and root planning group
      (C2), and tooth extraction group (C3). Group C2 rats were randomly divided into
      C2-1 (scaling and root planning group) and C2-2 (scaling and root
      planning+minocyline+systemic antibiotics group). Group C3 rats were randomly
      divided into C3-1 (tooth extraction group) and C3-2 (tooth extraction+systemic
      antibiotic group). One rat from group B was randomly selected and sacrificed
      after 15 weeks. Subsequently, the carotid vascular tissue was collected for oil
      red O staining. Modeling was successful when foam cell formation was observed.
      Periodontal treatments were conducted twice, and euthanasia was performed after
      the experiment. Moreover, double-carotid artery bifurcation was carried out to
      detect the expression of CRP and P. gingivalis. Immunohistochemical and 16sRNA
      semiquantitative methods were used to detect the CRP expression and the relative 
      contents of P. gingivalis, respectively. RESULTS: Immunohistochemical results
      showed that the CRP-positive expression in groups B and C was significantly
      higher than that in group A (P<0.05). The CRP-positive expression in other group 
      C rats were significantly lower than that in group C1 (P<0.05). The CRP-positive 
      expression in group C2-2 was the lowest among the groups (P<0.05). The relative
      quantity of P. gingivalis in group C1 was the highest and significantly higher
      than that in groups A and B (P<0.05). The relative quantities of P. gingivalis in
      groups C2-1, C2-2, C3-1, and C3-2 were significantly lower than that in group C1 
      (P<0.05), and the quantity in group C3-2 was the lowest (P<0.05). CONCLUSIONS:
      Rats with CP associated with HL will increase the CRP expression and oral
      bacteria quantity on carotid artery, and lesions will gradually aggravate.
      Interventions, such as periodontal basic treatment and tooth extraction, could
      improve carotid artery lesions. The basic treatment with local and systemic
      anti-inflammatory drugs exerts the most satisfactory effect on local CRP
      expression. Tooth extraction with antibiotics is an effective method on reducing 
      oral bacteria in carotid artery. Periodontal basic treatment associated with
      local and systemic antiflammatory drugs can obviously improve the effect..
FAU - Xiuyun, Ren
AU  - Xiuyun R
AD  - Dept. of Periodontology, School of Stomatology, Shanxi Medical University,
      Taiyuan 030001, China.
FAU - Chong, Wang
AU  - Chong W
AD  - Dept. of Periodontology, School of Stomatology, Shanxi Medical University,
      Taiyuan 030001, China.
FAU - Xin, Liu
AU  - Xin L
AD  - Dept. of Periodontology, School of Stomatology, Shanxi Medical University,
      Taiyuan 030001, China.
FAU - Hao, Li
AU  - Hao L
AD  - Dept. of Periodontology, School of Stomatology, Shanxi Medical University,
      Taiyuan 030001, China.
FAU - Qianhui, Ma
AU  - Qianhui M
AD  - Dept. of Periodontology, School of Stomatology, Shanxi Medical University,
      Taiyuan 030001, China.
FAU - Mu, Lin
AU  - Mu L
AD  - Dept. of Periodontology, School of Stomatology, Shanxi Medical University,
      Taiyuan 030001, China.
FAU - Xuexue, Shi
AU  - Xuexue S
AD  - Dept. of Periodontology, School of Stomatology, Shanxi Medical University,
      Taiyuan 030001, China.
FAU - Jinhua, Gao
AU  - Jinhua G
AD  - Dept. of Periodontology, School of Stomatology, Shanxi Medical University,
      Taiyuan 030001, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
OTO - NOTNLM
OT  - C-reactive protein
OT  - Porphyromonas gingivalis
OT  - hyperlipidemia
OT  - periodontal basic treatment
OT  - periodontitis
EDAT- 2017/07/07 06:00
MHDA- 2017/07/07 06:00
CRDT- 2017/07/07 06:00
AID - 10.7518/hxkq.2017.02.016 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Apr 1;35(2):192-197. doi:
      10.7518/hxkq.2017.02.016.