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Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers.

Abstract Although collagen microstructural crimp is a major determinant of ocular biomechanics, no direct measurements of optic nerve head (ONH) crimp have been reported. Our goal was to characterize the crimp period of the lamina cribrosa (LC) and peripapillary sclera (PPS) at low and normal IOPs.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28687851
OWN - NLM
STAT- MEDLINE
DA  - 20170708
DCOM- 20170714
LR  - 20170714
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen
      Fibers.
PG  - 3378-3388
LID - 10.1167/iovs.17-21811 [doi]
AB  - Purpose: Although collagen microstructural crimp is a major determinant of ocular
      biomechanics, no direct measurements of optic nerve head (ONH) crimp have been
      reported. Our goal was to characterize the crimp period of the lamina cribrosa
      (LC) and peripapillary sclera (PPS) at low and normal IOPs. Methods: ONHs from 11
      sheep eyes were fixed at 10-, 5-, or 0-mm Hg IOP and crimp periods measured
      manually from coronal cryosections imaged with polarized light microscopy (PLM). 
      Using linear mixed-effect models, we characterized the LC and PPS periods, and
      how they varied with distance from the scleral canal edge. Results: A total of
      17,374 manual collagen crimp period measurements were obtained with high
      repeatability (1.9 mum) and reproducibility (4.7 mum). The periods were smaller
      (P < 0.001) and less variable in the LC than in the PPS: average (SD) of 13.8
      (3.1) mum in the LC, and 31.0 (10.4) mum in the PPS. LC crimp period did not vary
      with distance from the scleral canal wall (P > 0.1). PPS period increased with
      the square root of the distance to the canal (P < 0.0001). Conclusions: Small,
      uniform crimp periods within the sheep LC and immediately adjacent PPS may
      indicate that these tissues are setup to prevent large or heterogeneous
      deformations that insult the neural tissues within the canal. An increasing more 
      variable period with distance from the canal provides a smooth transition of
      mechanical properties that minimizes stress and strain concentrations.
FAU - Jan, Ning-Jiun
AU  - Jan NJ
AD  - Department of Bioengineering, Swanson School of Engineering, University of
      Pittsburgh, Pennsylvania, United States 2Department of Ophthalmology, University 
      of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
      3McGowan Institute for Regenerative Medicine, University of Pittsburgh School of 
      Medicine and University of Pittsburgh, Pittsburgh, Pennsylvania, United States
      4The Louis J. Fox Center for Vision Restoration of UPMC and the University of
      Pittsburgh, Pittsburgh, Pennsylvania, United States.
FAU - Gomez, Celeste
AU  - Gomez C
AD  - Department of Bioengineering, Swanson School of Engineering, University of
      Pittsburgh, Pennsylvania, United States.
FAU - Moed, Saundria
AU  - Moed S
AD  - Department of Bioengineering, Swanson School of Engineering, University of
      Pittsburgh, Pennsylvania, United States.
FAU - Voorhees, Andrew P
AU  - Voorhees AP
AD  - Department of Ophthalmology, University of Pittsburgh School of Medicine,
      Pittsburgh, Pennsylvania, United States 3McGowan Institute for Regenerative
      Medicine, University of Pittsburgh School of Medicine and University of
      Pittsburgh, Pittsburgh, Pennsylvania, United States 4The Louis J. Fox Center for 
      Vision Restoration of UPMC and the University of Pittsburgh, Pittsburgh,
      Pennsylvania, United States.
FAU - Schuman, Joel S
AU  - Schuman JS
AD  - Department of Ophthalmology, University of Pittsburgh School of Medicine,
      Pittsburgh, Pennsylvania, United States 3McGowan Institute for Regenerative
      Medicine, University of Pittsburgh School of Medicine and University of
      Pittsburgh, Pittsburgh, Pennsylvania, United States 4The Louis J. Fox Center for 
      Vision Restoration of UPMC and the University of Pittsburgh, Pittsburgh,
      Pennsylvania, United States 5NYU Langone Eye Center, New York University, New
      York, New York, United States.
FAU - Bilonick, Richard A
AU  - Bilonick RA
AD  - Department of Ophthalmology, University of Pittsburgh School of Medicine,
      Pittsburgh, Pennsylvania, United States.
FAU - Sigal, Ian A
AU  - Sigal IA
AD  - Department of Bioengineering, Swanson School of Engineering, University of
      Pittsburgh, Pennsylvania, United States 2Department of Ophthalmology, University 
      of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
      3McGowan Institute for Regenerative Medicine, University of Pittsburgh School of 
      Medicine and University of Pittsburgh, Pittsburgh, Pennsylvania, United States
      4The Louis J. Fox Center for Vision Restoration of UPMC and the University of
      Pittsburgh, Pittsburgh, Pennsylvania, United States.
LA  - eng
GR  - R01 EY023966/EY/NEI NIH HHS/United States
GR  - R01 EY025011/EY/NEI NIH HHS/United States
GR  - R01 EY013178/EY/NEI NIH HHS/United States
GR  - T32 EY017271/EY/NEI NIH HHS/United States
GR  - P30 EY008098/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Collagen/*ultrastructure
MH  - Disease Models, Animal
MH  - Glaucoma/pathology/physiopathology
MH  - Intraocular Pressure/physiology
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*pathology/physiopathology
MH  - Sclera/*pathology
MH  - Sheep
PMC - PMC5501496
EDAT- 2017/07/09 06:00
MHDA- 2017/07/15 06:00
CRDT- 2017/07/09 06:00
AID - 2643390 [pii]
AID - 10.1167/iovs.17-21811 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3378-3388. doi:
      10.1167/iovs.17-21811.