PubTransformer

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PMID- 28687853
OWN - NLM
STAT- MEDLINE
DA  - 20170708
DCOM- 20170714
LR  - 20170714
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Alterations to the Foveal Cone Mosaic of Diabetic Patients.
PG  - 3395-3403
LID - 10.1167/iovs.17-21793 [doi]
AB  - Purpose: We measured localized changes occurring in the foveal cone
      photoreceptors and related defects in the cone mosaic to alterations in the
      nearby retinal vasculature. Methods: The central 4 degrees of the retina of 54
      diabetic (53.7 +/- 12.5 years) and 85 control (35.8 +/- 15.2 years) participants 
      were imaged with the Indiana adaptive optics scanning laser ophthalmoscope.
      Foveal cones and overlying retinal capillaries were imaged and infrared scanning 
      laser ophthalmoscopy (IR SLO) images and optical coherence tomography (OCT)
      B-scans were obtained. Follow-up imaging sessions were performed with intervals
      from 4 to 50 months for 22 of the 54 diabetic participants. Results: The foveal
      cone mosaics of 49 of 54 diabetic participants were of sufficient quality to
      assess the absence or presence of small localized defects in the cone mosaic. In 
      13 of these 49 diabetic participants we found localized defects, visualized as
      sharp-edged areas of cones with diminished reflectivity. These small, localized
      areas ranged in size from 10 x 10 mum to 75 x 30 mum. Of these 13 participants
      with cone defects, 11 were imaged over periods from 4 to 50 months and the
      defects remained relatively stable. These dark regions were not shadows of
      overlying retinal vessels, but all participants with these localized defects had 
      alterations in the juxtafoveal capillary network. Conclusions: The foveal cone
      mosaic can show localized areas of dark cones that persist over time, that
      apparently correspond to either missing or nonreflecting cones, and may be
      related to local retinal ischemia.
FAU - Sawides, Lucie
AU  - Sawides L
AD  - School of Optometry, Indiana University, Bloomington, Indiana, United States.
FAU - Sapoznik, Kaitlyn A
AU  - Sapoznik KA
AD  - School of Optometry, Indiana University, Bloomington, Indiana, United States.
FAU - de Castro, Alberto
AU  - de Castro A
AD  - School of Optometry, Indiana University, Bloomington, Indiana, United States.
FAU - Walker, Brittany R
AU  - Walker BR
AD  - School of Optometry, Indiana University, Bloomington, Indiana, United States.
FAU - Gast, Thomas J
AU  - Gast TJ
AD  - School of Optometry, Indiana University, Bloomington, Indiana, United States.
FAU - Elsner, Ann E
AU  - Elsner AE
AD  - School of Optometry, Indiana University, Bloomington, Indiana, United States.
FAU - Burns, Stephen A
AU  - Burns SA
AD  - School of Optometry, Indiana University, Bloomington, Indiana, United States.
LA  - eng
GR  - P30 EY019008/EY/NEI NIH HHS/United States
GR  - R01 EY024315/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus/*pathology
MH  - Female
MH  - Fovea Centralis/*pathology
MH  - Humans
MH  - Male
MH  - Microscopy, Confocal
MH  - Middle Aged
MH  - Ophthalmoscopy/methods
MH  - Retinal Cone Photoreceptor Cells/*pathology
MH  - Retinal Vessels/pathology
MH  - Tomography, Optical Coherence/methods
MH  - Young Adult
PMC - PMC5501497
EDAT- 2017/07/09 06:00
MHDA- 2017/07/15 06:00
CRDT- 2017/07/09 06:00
AID - 2643392 [pii]
AID - 10.1167/iovs.17-21793 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3395-3403. doi:
      10.1167/iovs.17-21793.