PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Curcumin protects against acoustic trauma in the rat cochlea.

Abstract In this study we evaluated the therapeutic utility of curcumin in a rodent model of acoustic trauma using histopathology, immunohistochemical, and distortion product otoacoustic emission (DPOAEs) measurements.
PMID
Related Publications

Effect of transtympanic betamethasone delivery to the inner ear.

Antioxidant treatment reduces blast-induced cochlear damage and hearing loss.

Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model.

Intraperitoneal curcumin and vitamin E combination for the treatment of cisplatin-induced ototoxicity in rats.

Investigation of the cochlear effects of intratympanic steroids administered following acoustic trauma.

Authors

Mayor MeshTerms
Keywords

Acoustic trauma

Apoptosis

Curcumin

Distortion product otoacoustic emission

Journal Title international journal of pediatric otorhinolaryngology
Publication Year Start




PMID- 28688549
OWN - NLM
STAT- MEDLINE
DA  - 20170709
DCOM- 20170803
LR  - 20170803
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 99
DP  - 2017 Aug
TI  - Curcumin protects against acoustic trauma in the rat cochlea.
PG  - 100-106
LID - S0165-5876(17)30249-5 [pii]
LID - 10.1016/j.ijporl.2017.05.029 [doi]
AB  - OBJECTIVES: In this study we evaluated the therapeutic utility of curcumin in a
      rodent model of acoustic trauma using histopathology, immunohistochemical, and
      distortion product otoacoustic emission (DPOAEs) measurements. METHODS: 28 Wistar
      albino rats were included in the study and randomly assigned to 4 treatment
      groups. The first group (group 1) served as the control and was exposed to
      acoustic trauma alone. Group 2 was the curcumin group. Group 3 was the curcumin
      plus acoustic trauma group. Group 4 was the saline plus acoustic trauma group.
      Otoacoustic emission measurements were collected at the end of the experiment and
      all animals were sacrificed. Cochlea were collected and prepared for TUNEL
      (TdT-mediated deoxyuridinetriphosphate nick end-labelling) staining assay.
      RESULTS: Group 3 maintained baseline DPOAEs values at 3000 Hz, 4000 Hz and 8000
      Hz on the 3rd and 5th day of the experiment. DPOAEs results were correlated with 
      the immunohistochemical and histopathological findings in all groups. In
      comparison to the histopathologic control group, Group 1 exhibited a
      statistically significant increase in apoptotic indices in the organ of Corti,
      inner hair cell, and outer hair cell areas (p < 0.05). Relative to the control
      group, rats in Group 3 showed little increase in inner hair cell and outer hair
      cell apoptotic indices. CONCLUSIONS: Our results support the conclusion that
      curcumin may protect the cochlear tissues from acoustic trauma in rats. Curcumin 
      injection prior to or after an acoustic trauma reduces cochlear hair cell damage 
      and may protect against hearing loss.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Soyalic, Harun
AU  - Soyalic H
AD  - Ahi Evran University, Training and Research Hospital Department of
      Otorhinolaryngology, Kirsehir, Turkey. Electronic address:
      [email protected]
FAU - Gevrek, Fikret
AU  - Gevrek F
AD  - Gaziosmanpasa University, Department of Histology and Embryology, Tokat, Turkey.
FAU - Karaman, Serhat
AU  - Karaman S
AD  - Gaziosmanpasa University, Department of Emergency Medicine, Tokat, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170605
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Apoptosis
MH  - Audiometry
MH  - Cochlea/drug effects/*pathology
MH  - Curcumin/*pharmacology
MH  - Hearing Loss, Noise-Induced/*drug therapy
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Otoacoustic Emissions, Spontaneous/*drug effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Acoustic trauma
OT  - Apoptosis
OT  - Curcumin
OT  - Distortion product otoacoustic emission
EDAT- 2017/07/10 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/10 06:00
PHST- 2017/03/31 [received]
PHST- 2017/05/30 [revised]
PHST- 2017/05/31 [accepted]
AID - S0165-5876(17)30249-5 [pii]
AID - 10.1016/j.ijporl.2017.05.029 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2017 Aug;99:100-106. doi:
      10.1016/j.ijporl.2017.05.029. Epub 2017 Jun 5.