PubTransformer

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PMID- 28688553
OWN - NLM
STAT- MEDLINE
DA  - 20170709
DCOM- 20170803
LR  - 20170803
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 99
DP  - 2017 Aug
TI  - Clinical role of electrocochleography in children with auditory neuropathy
      spectrum disorder.
PG  - 120-127
LID - S0165-5876(17)30246-X [pii]
LID - 10.1016/j.ijporl.2017.05.026 [doi]
AB  - OBJECTIVES: To assess electrocochleography (ECochG) to tones as an instrument to 
      account for CI speech perception outcomes in children with auditory neuropathy
      spectrum disorder (ANSD). MATERIALS & METHODS: Children (<18 years) receiving CIs
      for ANSD (n = 30) and non-ANSD (n = 74) etiologies of hearing loss were evaluated
      with ECochG using tone bursts (0.25-4 kHz). The total response (TR) is the sum of
      spectral peaks of responses across frequencies. The compound action potential
      (CAP) and the auditory nerve neurophonic (ANN) in ECochG waveforms were used to
      estimate nerve activity and calculate nerve score. Performance on open-set
      monosyllabic word tests was the outcome measure. Standard statistical methods
      were applied. RESULTS: On average, TR was larger in ANSD than in non-ANSD
      subjects. Most ANSD (73.3%) and non-ANSD (87.8%) subjects achieved open-set
      speech perception; TR accounted for 33% and 20% of variability in the outcomes,
      respectively. In the ANSD group, the PTA accounted for 69.3% of the variability, 
      but there was no relationship with outcomes in the non-ANSD group. In both
      populations, nerve score was sensitive in identifying subjects at risk for not
      acquiring open-set speech perception, while the CAP and the ANN were more
      specific. CONCLUSION: In both subject groups, the TRs correlated with outcomes
      but these measures were notably larger in the ANSD group. There was also strong
      correlation between PTA and speech perception outcome in ANSD group. In both
      subject populations, weaker evidence of neural activity was related to failure to
      achieve open-set speech perception.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Fontenot, Tatyana E
AU  - Fontenot TE
AD  - University of North Carolina at Chapel Hill, Department of Otolaryngology, Chapel
      Hill, NC, United States. Electronic address: [email protected]
FAU - Giardina, Christopher K
AU  - Giardina CK
AD  - University of North Carolina at Chapel Hill, Department of Otolaryngology, Chapel
      Hill, NC, United States; University of North Carolina School of Medicine, Chapel 
      Hill, NC, United States.
FAU - Teagle, Holly F
AU  - Teagle HF
AD  - University of North Carolina at Chapel Hill, Department of Otolaryngology, Chapel
      Hill, NC, United States.
FAU - Park, Lisa R
AU  - Park LR
AD  - University of North Carolina at Chapel Hill, Department of Otolaryngology, Chapel
      Hill, NC, United States.
FAU - Adunka, Oliver F
AU  - Adunka OF
AD  - The Ohio State University, Department of Otolaryngology, Columbus, OH, United
      States.
FAU - Buchman, Craig A
AU  - Buchman CA
AD  - Washington University in St. Louis, Department of Otolaryngology, St. Louis, MO, 
      United States.
FAU - Brown, Kevin D
AU  - Brown KD
AD  - University of North Carolina at Chapel Hill, Department of Otolaryngology, Chapel
      Hill, NC, United States.
FAU - Fitzpatrick, Douglas C
AU  - Fitzpatrick DC
AD  - University of North Carolina at Chapel Hill, Department of Otolaryngology, Chapel
      Hill, NC, United States; University of North Carolina School of Medicine, Chapel 
      Hill, NC, United States.
LA  - eng
GR  - T32 DC005360/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
DEP - 20170605
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - Auditory neuropathy
SB  - IM
MH  - Adolescent
MH  - Audiometry, Evoked Response/*methods
MH  - Child
MH  - Child, Preschool
MH  - Cochlear Implantation/*methods
MH  - Cohort Studies
MH  - Deafness/physiopathology/surgery
MH  - Female
MH  - Hearing Loss, Central/*physiopathology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - Speech Perception/*physiology
MH  - Vestibulocochlear Nerve Diseases/surgery
PMC - PMC5538887
MID - NIHMS884761
OTO - NOTNLM
OT  - Auditory nerve neurophonic
OT  - Auditory neuropathy spectrum disorder
OT  - Cochlear implants
OT  - Compound action potential
OT  - Electrocochleography
EDAT- 2017/07/10 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/10 06:00
PMCR- 2018/08/01
PHST- 2017/02/17 [received]
PHST- 2017/05/26 [revised]
PHST- 2017/05/31 [accepted]
AID - S0165-5876(17)30246-X [pii]
AID - 10.1016/j.ijporl.2017.05.026 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2017 Aug;99:120-127. doi:
      10.1016/j.ijporl.2017.05.026. Epub 2017 Jun 5.