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Characterization of PTV-12, a newly described porcine teschovirus serotype: in vivo infection and cross-protection studies.

Abstract Porcine teschoviruses (PTVs) constitute 1 of the 31 genera within the Picornaviridae family, comprising at least 13 genetic types (PTV-1 to PTV-13), of which only 11 (PTV-1 to PTV-11) have been recognized as serotypes to date. Specific for swine and wild boars, most PTVs are usually non-pathogenic, but some viral variants cause severe disorders in the central nervous system (Teschen disease) or milder signs (Talfan disease), as well as reproductive, digestive and respiratory disorders and skin lesions. Previous studies revealed a high diversity of teschoviruses circulating in Spanish pig populations. Phylogenetic analysis performed with these sequences and others available in GenBank disclosed 13 clusters, 11 of which corresponded to the known PTV serotypes, and 1 of 2 additional groups is represented by isolate CC25, whose full-length genomic sequence has been obtained. This group is new to science, and was putatively named PTV-12. Here, a complete characterization of this isolate is presented, including the experimental infection of minipigs to assess tissue tropism and possible pathogenicity in vivo in the host species. In addition, using this experimental animal model, we investigated whether a pre-existing infection with this PTV-12 isolate could confer cross-protection against infection with a heterotypic PTV-1 virulent strain. Based on phylogenetic analysis and serological data, we propose CC25 as the prototype strain of a new teschovirus serotype, PTV-12.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the journal of general virology
Publication Year Start




PMID- 28691894
OWN - NLM
STAT- MEDLINE
DA  - 20170710
DCOM- 20170804
LR  - 20170804
IS  - 1465-2099 (Electronic)
IS  - 0022-1317 (Linking)
VI  - 98
IP  - 7
DP  - 2017 Jul
TI  - Characterization of PTV-12, a newly described porcine teschovirus serotype: in
      vivo infection and cross-protection studies.
PG  - 1636-1645
LID - 10.1099/jgv.0.000822 [doi]
AB  - Porcine teschoviruses (PTVs) constitute 1 of the 31 genera within the
      Picornaviridae family, comprising at least 13 genetic types (PTV-1 to PTV-13), of
      which only 11 (PTV-1 to PTV-11) have been recognized as serotypes to date.
      Specific for swine and wild boars, most PTVs are usually non-pathogenic, but some
      viral variants cause severe disorders in the central nervous system (Teschen
      disease) or milder signs (Talfan disease), as well as reproductive, digestive and
      respiratory disorders and skin lesions. Previous studies revealed a high
      diversity of teschoviruses circulating in Spanish pig populations. Phylogenetic
      analysis performed with these sequences and others available in GenBank disclosed
      13 clusters, 11 of which corresponded to the known PTV serotypes, and 1 of 2
      additional groups is represented by isolate CC25, whose full-length genomic
      sequence has been obtained. This group is new to science, and was putatively
      named PTV-12. Here, a complete characterization of this isolate is presented,
      including the experimental infection of minipigs to assess tissue tropism and
      possible pathogenicity in vivo in the host species. In addition, using this
      experimental animal model, we investigated whether a pre-existing infection with 
      this PTV-12 isolate could confer cross-protection against infection with a
      heterotypic PTV-1 virulent strain. Based on phylogenetic analysis and serological
      data, we propose CC25 as the prototype strain of a new teschovirus serotype,
      PTV-12.
FAU - Cano-Gomez, Cristina
AU  - Cano-Gomez C
AD  - 1Centro de Investigacion en Sanidad Animal (CISA)-INIA, Ctra Algete-El Casar s/n,
      28130 Valdeolmos, Spain.
FAU - Fernandez-Pinero, Jovita
AU  - Fernandez-Pinero J
AD  - 1Centro de Investigacion en Sanidad Animal (CISA)-INIA, Ctra Algete-El Casar s/n,
      28130 Valdeolmos, Spain.
FAU - Garcia-Casado, Maria Ana
AU  - Garcia-Casado MA
AD  - 1Centro de Investigacion en Sanidad Animal (CISA)-INIA, Ctra Algete-El Casar s/n,
      28130 Valdeolmos, Spain.
FAU - Zell, Roland
AU  - Zell R
AD  - 2Department for Virology and Antiviral Therapy, Jena University Hospital,
      Friedrich Schiller University, Hans-Knoell-Str 2, 07745 Jena, Germany.
FAU - Jimenez-Clavero, Miguel Angel
AU  - Jimenez-Clavero MA
AD  - 1Centro de Investigacion en Sanidad Animal (CISA)-INIA, Ctra Algete-El Casar s/n,
      28130 Valdeolmos, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170710
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/blood
MH  - Antibodies, Viral/blood
MH  - Cross Protection/*immunology
MH  - Picornaviridae Infections/*immunology/virology
MH  - Serogroup
MH  - Serotyping
MH  - Spain
MH  - Swine
MH  - Swine Diseases/*immunology/virology
MH  - Swine, Miniature/*virology
MH  - Teschovirus/*classification/genetics/*immunology/isolation & purification
MH  - Viral Tropism/*physiology
MH  - Viremia/virology
EDAT- 2017/07/12 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/11 06:00
AID - 10.1099/jgv.0.000822 [doi]
PST - ppublish
SO  - J Gen Virol. 2017 Jul;98(7):1636-1645. doi: 10.1099/jgv.0.000822. Epub 2017 Jul
      10.