PubTransformer

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PMID- 28692739
OWN - NLM
STAT- MEDLINE
DA  - 20170710
DCOM- 20170714
LR  - 20170715
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Analysis of Retinal Architectural Changes Using Intraoperative OCT Following
      Surgical Manipulations With Membrane Flex Loop in the DISCOVER Study.
PG  - 3440-3444
LID - 10.1167/iovs.17-21584 [doi]
AB  - Purpose: We investigate acute retinal alterations identified on intraoperative
      optical coherence tomography (iOCT) immediately following surgical intervention
      with the Finesse Flex Loop for vitreoretinal interface disorders. Methods: The
      Determination of feasibility of Intraoperative Spectral domain microscope
      Combined/integrated OCT Visualization during En face Retinal and ophthalmic
      surgery (DISCOVER) study is a prospective multisurgeon intraoperative OCT
      clinical study. Subjects who had participated in the DISCOVER study and had
      undergone macular surgery with the membrane flex loop from August 2014 to July
      2016 were identified. iOCT images and video sequences were evaluated at various
      surgical time points. Subjects were excluded if iOCT images were not obtained
      over the area of membrane peeling performed with the membrane flex loop.
      Qualitative characteristics of intraoperative changes in retinal images were
      analyzed, with particular focus on the retinal layers within the bed of membrane 
      peeling performed specifically with the membrane flex loop. Results: We studied
      34 eyes of 34 patients, with a mean age of 72.7 (+/- 6.4) years, 25 of whom were 
      women. The intraoperative diagnosis was full thickness macular hole in 21 eyes
      (62%) and epiretinal membrane in 13 (38%). All eyes had successful indocyanine
      green-assisted inner limiting membrane (ILM) flap initiation using the membrane
      loop. Intraoperative OCT demonstrated expansion of the ellipsoid zone-to-RPE
      distance in 3 eyes (9%), definitive subretinal fluid accumulation in 1 eye (3%), 
      and hyperreflectivity of the inner retinal layers associated with retinal
      hemorrhage in 10 eyes (29%). Retinal breaks were not observed in any eye.
      Conclusions: Acute retinal alterations after ILM peeling with the membrane flex
      loop were visualized at a frequency of less than 10%. Additional research is
      needed to understand the clinical impact, if any, of these architectural
      alterations.
FAU - Uchida, Atsuro
AU  - Uchida A
AD  - Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio,
      United States 2Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United
      States.
FAU - Srivastava, Sunil K
AU  - Srivastava SK
AD  - Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio,
      United States 2Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United
      States.
FAU - Ehlers, Justis P
AU  - Ehlers JP
AD  - Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio,
      United States 2Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United
      States.
LA  - eng
GR  - K23 EY022947/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Epiretinal Membrane/*surgery
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Macula Lutea/surgery
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Perforations/*surgery
MH  - Tomography, Optical Coherence/methods
MH  - Vitrectomy/*methods
PMC - PMC5505120
EDAT- 2017/07/12 06:00
MHDA- 2017/07/15 06:00
CRDT- 2017/07/11 06:00
AID - 2643581 [pii]
AID - 10.1167/iovs.17-21584 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3440-3444. doi:
      10.1167/iovs.17-21584.