PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Urinary bladder cancer risk factors in an area of former coal, iron, and steel industries in Germany.

Abstract This study was performed to investigate the frequency of bladder cancer in patients with an occupational history such as underground hard coal mining and/or painting after the structural change in the local industry. A total of 206 patients with bladder cancer and 207 controls were enlisted regarding occupational and nonoccupational bladder cancer risk factors by questionnaire. The phase II enzymes N-acetyltransferase 2 (NAT2), glutathione S-transferases M1 (GSTM1), and T1 (GSTT1) and the single nucleotide polymorphism (SNP) rs11892031[A/C] reported to be associated with bladder cancer in genome-wide association studies were genotyped. The bladder cancer risk in varnishers and underground hard coal miners was increased as previously shown in a study in this area performed in the 1980s. The occupation of a car mechanic was associated with a significantly elevated bladder cancer risk and higher in the case of underground hard coal miners even though the mine was closed in 1987. The frequency of GSTM1 negative genotype was comparable in cases and controls (53% versus 54%). In the case of NAT2, the slow NAT2 genotype was more frequent (62% versus 58%) and ultra-slow NAT2 genotype (NAT2*6A and/or *7B alleles only) was 23% versus 15%. An occupational history of a varnisher or an underground hard coal miner remains a risk factor for bladder cancer occurrence. Data indicate that in the case of bladder cancer, GSTM1 is a susceptibility factor related to environmental and/or occupational exposure.
PMID
Related Publications

Urothelial cancer of the bladder in an area of former coal, iron, and steel industries in Germany: a case-control study.

Occupational risk factors for prostate cancer in an area of former coal, iron, and steel industries in Germany. Part 1: Results from a study performed in the 1980s.

Occupational risk factors for prostate cancer in an area of former coal, iron, and steel industries in Germany. Part 2: results from a study performed in the 1990s.

Occupational bladder cancer: Polymorphisms of xenobiotic metabolizing enzymes, exposures, and prognosis.

Polymorphic enzymes, urinary bladder cancer risk, and structural change in the local industry.

Authors

Mayor MeshTerms

Coal Mining

Extraction and Processing Industry

Keywords
Journal Title journal of toxicology and environmental health. part a
Publication Year Start




PMID- 28696895
OWN - NLM
STAT- MEDLINE
DA  - 20170711
DCOM- 20170830
LR  - 20170830
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 80
IP  - 7-8
DP  - 2017
TI  - Urinary bladder cancer risk factors in an area of former coal, iron, and steel
      industries in Germany.
PG  - 430-438
LID - 10.1080/10937404.2017.1304719 [doi]
AB  - This study was performed to investigate the frequency of bladder cancer in
      patients with an occupational history such as underground hard coal mining and/or
      painting after the structural change in the local industry. A total of 206
      patients with bladder cancer and 207 controls were enlisted regarding
      occupational and nonoccupational bladder cancer risk factors by questionnaire.
      The phase II enzymes N-acetyltransferase 2 (NAT2), glutathione S-transferases M1 
      (GSTM1), and T1 (GSTT1) and the single nucleotide polymorphism (SNP)
      rs11892031[A/C] reported to be associated with bladder cancer in genome-wide
      association studies were genotyped. The bladder cancer risk in varnishers and
      underground hard coal miners was increased as previously shown in a study in this
      area performed in the 1980s. The occupation of a car mechanic was associated with
      a significantly elevated bladder cancer risk and higher in the case of
      underground hard coal miners even though the mine was closed in 1987. The
      frequency of GSTM1 negative genotype was comparable in cases and controls (53%
      versus 54%). In the case of NAT2, the slow NAT2 genotype was more frequent (62%
      versus 58%) and ultra-slow NAT2 genotype (NAT2*6A and/or *7B alleles only) was
      23% versus 15%. An occupational history of a varnisher or an underground hard
      coal miner remains a risk factor for bladder cancer occurrence. Data indicate
      that in the case of bladder cancer, GSTM1 is a susceptibility factor related to
      environmental and/or occupational exposure.
FAU - Krech, Eugen
AU  - Krech E
AD  - a Department of Urology, Klinikum Dortmund GmbH , Dortmund , Germany.
FAU - Selinski, Silvia
AU  - Selinski S
AD  - b Leibniz Research Centre for Working Environment and Human Factors at TU
      Dortmund (IfADo) , Dortmund , Germany.
FAU - Blaszkewicz, Meinolf
AU  - Blaszkewicz M
AD  - b Leibniz Research Centre for Working Environment and Human Factors at TU
      Dortmund (IfADo) , Dortmund , Germany.
FAU - Burger, Hannah
AU  - Burger H
AD  - b Leibniz Research Centre for Working Environment and Human Factors at TU
      Dortmund (IfADo) , Dortmund , Germany.
AD  - c Faculty of Statistics , TU Dortmund University , Dortmund , Germany.
FAU - Kadhum, Thura
AU  - Kadhum T
AD  - b Leibniz Research Centre for Working Environment and Human Factors at TU
      Dortmund (IfADo) , Dortmund , Germany.
FAU - Hengstler, Jan G
AU  - Hengstler JG
AD  - b Leibniz Research Centre for Working Environment and Human Factors at TU
      Dortmund (IfADo) , Dortmund , Germany.
FAU - Truss, Michael C
AU  - Truss MC
AD  - a Department of Urology, Klinikum Dortmund GmbH , Dortmund , Germany.
FAU - Golka, Klaus
AU  - Golka K
AD  - b Leibniz Research Centre for Working Environment and Human Factors at TU
      Dortmund (IfADo) , Dortmund , Germany.
LA  - eng
PT  - Journal Article
DEP - 20170711
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 12597-69-2 (Steel)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - *Coal Mining
MH  - *Extraction and Processing Industry
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Iron
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/chemically induced/*epidemiology
MH  - Risk Factors
MH  - Steel
MH  - Urinary Bladder Neoplasms/*epidemiology/etiology
EDAT- 2017/07/12 06:00
MHDA- 2017/08/31 06:00
CRDT- 2017/07/12 06:00
AID - 10.1080/10937404.2017.1304719 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2017;80(7-8):430-438. doi:
      10.1080/10937404.2017.1304719. Epub 2017 Jul 11.