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Genetically stable infectious Schmallenberg virus persists in foetal envelopes of pregnant ewes.

Abstract Schmallenberg virus (SBV) is a recently emerged vector-borne virus, inducing congenital defects in bovines, ovines and caprines. Here we have shown that infectious SBV is capable of persisting until the moment of birth in the foetal envelopes of ewes infected with SBV-infectious serum at day 45 (1/5 positive) and 60 (4/6 positive) of gestation. This persistence of at least 100 days is a new aspect of the SBV pathogenesis that could help to explain how SBV overwinters the cold season in temperate climate zones. Furthermore, sequencing of the M segment shows that the persisting virus in the foetal envelopes is genetically stable since only a few mutations compared to the inoculum were found. This supports the hypothesis that persisting virus could start the infection of new hosts. Finally, neutralization tests showed that infectious SBV present in the foetal envelopes at birth can be neutralized by the humoral immunity present in the infected ewes.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the journal of general virology
Publication Year Start




PMID- 28699878
OWN - NLM
STAT- MEDLINE
DA  - 20170712
DCOM- 20170804
LR  - 20170804
IS  - 1465-2099 (Electronic)
IS  - 0022-1317 (Linking)
VI  - 98
IP  - 7
DP  - 2017 Jul
TI  - Genetically stable infectious Schmallenberg virus persists in foetal envelopes of
      pregnant ewes.
PG  - 1630-1635
LID - 10.1099/jgv.0.000841 [doi]
AB  - Schmallenberg virus (SBV) is a recently emerged vector-borne virus, inducing
      congenital defects in bovines, ovines and caprines. Here we have shown that
      infectious SBV is capable of persisting until the moment of birth in the foetal
      envelopes of ewes infected with SBV-infectious serum at day 45 (1/5 positive) and
      60 (4/6 positive) of gestation. This persistence of at least 100 days is a new
      aspect of the SBV pathogenesis that could help to explain how SBV overwinters the
      cold season in temperate climate zones. Furthermore, sequencing of the M segment 
      shows that the persisting virus in the foetal envelopes is genetically stable
      since only a few mutations compared to the inoculum were found. This supports the
      hypothesis that persisting virus could start the infection of new hosts. Finally,
      neutralization tests showed that infectious SBV present in the foetal envelopes
      at birth can be neutralized by the humoral immunity present in the infected ewes.
FAU - Poskin, Antoine
AU  - Poskin A
AD  - 1CODA-CERVA, Operational Directorate Viral Diseases, Groeselenberg 99, 1180
      Brussels, Belgium.
FAU - Martinelle, Ludovic
AU  - Martinelle L
AD  - 2University of Liege, Research Unit of Epidemiology and Risk Analysis Applied to 
      Veterinary Sciences (UREAR-ULg), Fundamental and Applied Research for Animals and
      Health (FARAH) Center, Avenue de Cureghem 7A, 4000 Liege, Belgium.
FAU - Van der Stede, Yves
AU  - Van der Stede Y
AD  - 3European Food Safety Authority, Via Carlo Magno 1A, 43126 Parma, Italy.
FAU - Saegerman, Claude
AU  - Saegerman C
AD  - 2University of Liege, Research Unit of Epidemiology and Risk Analysis Applied to 
      Veterinary Sciences (UREAR-ULg), Fundamental and Applied Research for Animals and
      Health (FARAH) Center, Avenue de Cureghem 7A, 4000 Liege, Belgium.
FAU - Cay, Brigitte
AU  - Cay B
AD  - 1CODA-CERVA, Operational Directorate Viral Diseases, Groeselenberg 99, 1180
      Brussels, Belgium.
FAU - De Regge, Nick
AU  - De Regge N
AD  - 1CODA-CERVA, Operational Directorate Viral Diseases, Groeselenberg 99, 1180
      Brussels, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20170712
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Antibodies, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/immunology
MH  - Base Sequence
MH  - Bunyaviridae Infections/immunology/*virology
MH  - Chorion/*virology
MH  - Female
MH  - Orthobunyavirus/*genetics/immunology/isolation & purification
MH  - Placenta/*virology
MH  - Pregnancy
MH  - RNA, Viral/*genetics
MH  - Sequence Analysis, RNA
MH  - Sheep/*virology
MH  - Sheep Diseases/immunology/*virology
EDAT- 2017/07/13 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/13 06:00
AID - 10.1099/jgv.0.000841 [doi]
PST - ppublish
SO  - J Gen Virol. 2017 Jul;98(7):1630-1635. doi: 10.1099/jgv.0.000841. Epub 2017 Jul
      12.