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Sepsis due to Streptococcus pneumoniae associated with secondary hemophagocytic lymphohistiocytosis in a splenectomized patient for spherocytosis: A case report.

Abstract Hemophagocytic lymphohistiocytosis (HLH) is a syndrome that is characterized by an inappropriate hyperinflammatory immune response - primary, as a consequence of a genetic defect of NK cells and cytotoxic T lymphocytes or - secondary, in the progression of infections, rheumatic or autoimmune diseases, malignancies or metabolic diseases.
PMID
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Authors

Mayor MeshTerms

Splenectomy

Keywords
Journal Title medicine
Publication Year Start




PMID- 28700505
OWN - NLM
STAT- MEDLINE
DA  - 20170712
DCOM- 20170724
LR  - 20170724
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 28
DP  - 2017 Jul
TI  - Sepsis due to Streptococcus pneumoniae associated with secondary hemophagocytic
      lymphohistiocytosis in a splenectomized patient for spherocytosis: A case report.
PG  - e7520
LID - 10.1097/MD.0000000000007520 [doi]
AB  - RATIONALE: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome that is
      characterized by an inappropriate hyperinflammatory immune response - primary, as
      a consequence of a genetic defect of NK cells and cytotoxic T lymphocytes or -
      secondary, in the progression of infections, rheumatic or autoimmune diseases,
      malignancies or metabolic diseases. PATIENT CONCERNS: We present the case of a
      secondary HLH due to Streptococcus pneumoniae infection in a splenectomised
      patient for spherocytosis, a 37-year-old patient who was splenectomised in
      childhood for spherocytosis, without immuneprophylaxis induced by
      antipneumococcal vaccine. OUTCOMES: He developed a severe pneumococcal sepsis
      associated with secondary HLH, with unfavorable outcome and death. LESSONS: To
      our knowledge, just 2 similar cases had been published in the literature, none in
      which the secondary HLH was the consequence of an invasive pneumococcal infection
      in a splenectomized patient for spherocytosis, and the association of splenectomy
      with HLH is surprizin.
FAU - Birlutiu, Victoria
AU  - Birlutiu V
AD  - aFaculty of Medicine Sibiu, Lucian Blaga University of Sibiu bAcademic Emergency 
      Hospital Sibiu, Infectious Diseases Clinic, Sibiu cSpitalul Clinic de
      Ortopedie-Traumatologie si TBC Osteoarticular "Foisor" Bucuresti, Romania.
FAU - Birlutiu, Rares Mircea
AU  - Birlutiu RM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Fatal Outcome
MH  - Humans
MH  - Lymphohistiocytosis, Hemophagocytic/*etiology/pathology/therapy
MH  - Male
MH  - Pneumococcal Infections/*complications/pathology/therapy
MH  - Sepsis/*etiology/pathology/therapy
MH  - Spherocytosis, Hereditary/complications/*surgery
MH  - *Splenectomy
EDAT- 2017/07/13 06:00
MHDA- 2017/07/25 06:00
CRDT- 2017/07/13 06:00
AID - 10.1097/MD.0000000000007520 [doi]
AID - 00005792-201707140-00043 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(28):e7520. doi: 10.1097/MD.0000000000007520.