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Magnetic resonance imaging and spectroscopy for differential assessment of liver abnormalities induced by Opisthorchis felineus in an animal model.

Abstract European liver fluke Opisthorchis felineus, causing opisthorchiasis disease, is widespread in Russia, Ukraine, Kazakhstan and sporadically detected in the EU countries. O. felineus infection leads to hepatobiliary pathological changes, cholangitis, fibrosis and, in severe cases, malignant transformation of bile ducts. Due to absence of specific symptoms, the infection is frequently neglected for a long period. The association of opisthorchiasis with almost incurable bile duct cancer and rising international migration of people that increases the risk of the parasitic etiology of liver fibrosis in non-endemic regions determine high demand for development of approaches to opisthorchiasis detection.
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Authors

Mayor MeshTerms
Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28708894
OWN - NLM
STAT- Publisher
DA  - 20170714
LR  - 20170714
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 7
DP  - 2017 Jul 14
TI  - Magnetic resonance imaging and spectroscopy for differential assessment of liver 
      abnormalities induced by Opisthorchis felineus in an animal model.
PG  - e0005778
LID - 10.1371/journal.pntd.0005778 [doi]
AB  - BACKGROUND: European liver fluke Opisthorchis felineus, causing opisthorchiasis
      disease, is widespread in Russia, Ukraine, Kazakhstan and sporadically detected
      in the EU countries. O. felineus infection leads to hepatobiliary pathological
      changes, cholangitis, fibrosis and, in severe cases, malignant transformation of 
      bile ducts. Due to absence of specific symptoms, the infection is frequently
      neglected for a long period. The association of opisthorchiasis with almost
      incurable bile duct cancer and rising international migration of people that
      increases the risk of the parasitic etiology of liver fibrosis in non-endemic
      regions determine high demand for development of approaches to opisthorchiasis
      detection. METHODOLOGY/PRINCIPAL FINDINGS: In vivo magnetic resonance imaging and
      spectroscopy (MRI and MRS) were applied for differential assessment of hepatic
      abnormalities induced by O. felineus in an experimental animal model.
      Correlations of the MR-findings with the histological data as well as the data of
      the biochemical analysis of liver tissue were found. MRI provides valuable
      information about the severity of liver impairments induced by opisthorchiasis.
      An MR image of O. felineus infected liver has a characteristic pattern that
      differs from that of closely related liver fluke infections. 1H and 31P MRS in
      combination with biochemical analysis data showed that O. felineus infection
      disturbed hepatic metabolism of the host, which was accompanied by cholesterol
      accumulation in the liver. CONCLUSIONS: A non-invasive approach based on the
      magnetic resonance technique is very advantageous and may be successfully used
      not only for diagnosing and evaluating liver damage induced by O. felineus, but
      also for investigating metabolic changes arising in the infected organ. Since
      damages induced by the liver fluke take place in different liver lobes, MRI has
      the potential to overcome liver biopsy sampling variability that limits
      predictive validity of biopsy analysis for staging liver fluke-induced fibrosis.
FAU - Pershina, Alexandra G
AU  - Pershina AG
AUID- ORCID: http://orcid.org/0000-0001-7604-9722
AD  - Central Research Laboratory, Siberian State Medical University, Tomsk, Russia.
AD  - Department of Biotechnology and Organic Chemistry, National Research Tomsk
      Polytechnic University, Tomsk, Russia.
FAU - Ivanov, Vladimir V
AU  - Ivanov VV
AD  - Central Research Laboratory, Siberian State Medical University, Tomsk, Russia.
FAU - Efimova, Lina V
AU  - Efimova LV
AD  - Central Research Laboratory, Siberian State Medical University, Tomsk, Russia.
FAU - Shevelev, Oleg B
AU  - Shevelev OB
AD  - Center for Genetic Resources of Laboratory Animals, Institute of Cytology and
      Genetics SB RAS, Novosibirsk, Russia.
FAU - Vtorushin, Sergey V
AU  - Vtorushin SV
AD  - Central Research Laboratory, Siberian State Medical University, Tomsk, Russia.
FAU - Perevozchikova, Tatjana V
AU  - Perevozchikova TV
AD  - Central Research Laboratory, Siberian State Medical University, Tomsk, Russia.
FAU - Sazonov, Alexey E
AU  - Sazonov AE
AD  - Central Research Laboratory, Siberian State Medical University, Tomsk, Russia.
FAU - Ogorodova, Ludmila M
AU  - Ogorodova LM
AD  - Central Research Laboratory, Siberian State Medical University, Tomsk, Russia.
LA  - eng
PT  - Journal Article
DEP - 20170714
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
EDAT- 2017/07/15 06:00
MHDA- 2017/07/15 06:00
CRDT- 2017/07/15 06:00
PHST- 2017/03/31 [received]
PHST- 2017/07/05 [accepted]
AID - 10.1371/journal.pntd.0005778 [doi]
AID - PNTD-D-17-00478 [pii]
PST - aheadofprint
SO  - PLoS Negl Trop Dis. 2017 Jul 14;11(7):e0005778. doi:
      10.1371/journal.pntd.0005778.