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Influence of endoscopic sinus surgery on the quality of life of patients with early nasopharyngeal carcinoma and the analysis of prognosis-related factors.

Abstract The aim of this study is investigate the influence of endoscopic sinus surgery on the quality of life and prognosis of patients with early nasopharyngeal carcinoma. Patients initially diagnosed with early nasopharyngeal carcinoma and received surgical treatment were matched with nasopharyngeal carcinoma patients who received chemoradiotherapy at a ratio of 1:1, according to the following seven factors: gender, age, T staging, N staging, clinical staging, radiotherapy options, and chemotherapy options. Patients in the surgery group received endoscopic sinus surgery plus chemoradiotherapy, while subjects in the control group received chemoradiotherapy. The quality of life of patients before and after treatment was evaluated based on the FACT-H&N (Functional Assessment of Cancer Therapy-Head and Neck) and QLQ-H&N35 (Head and Neck Cancer Specific Module) questionnaires. In addition, overall survival and disease-free survival were compared between these two groups. The results showed overall survival was superior in the surgery group compared with the control group ( p = 0.007). However, the difference in disease-free survival between these two groups was not statistically significant ( p = 0.128). Furthermore, subgroup analysis revealed that for N0 patients, the effect of surgery combined with chemoradiotherapy on overall survival was superior to that of chemoradiotherapy ( p = 0.048); while for N1 patients, the difference in overall survival between these two groups was not statistically significant ( p = 0.065). For early nasopharyngeal carcinoma patients without lymph node metastasis, overall survival and disease-free survival in T1 patients were superior to those in T2 patients (χ(2) = 4.403, p = 0.036; χ(2) = 4.542, p = 0.033). At the end of treatment, the pain score was found to be significantly lower in the surgery group than in the chemoradiotherapy group ( p = 0.027). At 3 months and 1 year after treatment, dry mouth scores were significantly lower in the surgery group than in the chemoradiotherapy group ( p = 0.002, p = 0.026). These results demonstrated that the curative effect of surgery combined with chemoradiotherapy in the treatment of nasopharyngeal carcinoma was satisfactory and was particularly suitable for N0 patients.
PMID
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Authors

Mayor MeshTerms
Keywords

Nasopharyngeal carcinoma

chemotherapy

endoscopic sinus χsurgery

prognosis

quality of life

radiotherapy

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28714364
OWN - NLM
STAT- MEDLINE
DA  - 20170717
DCOM- 20170726
LR  - 20170726
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 7
DP  - 2017 Jul
TI  - Influence of endoscopic sinus surgery on the quality of life of patients with
      early nasopharyngeal carcinoma and the analysis of prognosis-related factors.
PG  - 1010428317707435
LID - 10.1177/1010428317707435 [doi]
AB  - The aim of this study is investigate the influence of endoscopic sinus surgery on
      the quality of life and prognosis of patients with early nasopharyngeal
      carcinoma. Patients initially diagnosed with early nasopharyngeal carcinoma and
      received surgical treatment were matched with nasopharyngeal carcinoma patients
      who received chemoradiotherapy at a ratio of 1:1, according to the following
      seven factors: gender, age, T staging, N staging, clinical staging, radiotherapy 
      options, and chemotherapy options. Patients in the surgery group received
      endoscopic sinus surgery plus chemoradiotherapy, while subjects in the control
      group received chemoradiotherapy. The quality of life of patients before and
      after treatment was evaluated based on the FACT-H&N (Functional Assessment of
      Cancer Therapy-Head and Neck) and QLQ-H&N35 (Head and Neck Cancer Specific
      Module) questionnaires. In addition, overall survival and disease-free survival
      were compared between these two groups. The results showed overall survival was
      superior in the surgery group compared with the control group ( p = 0.007).
      However, the difference in disease-free survival between these two groups was not
      statistically significant ( p = 0.128). Furthermore, subgroup analysis revealed
      that for N0 patients, the effect of surgery combined with chemoradiotherapy on
      overall survival was superior to that of chemoradiotherapy ( p = 0.048); while
      for N1 patients, the difference in overall survival between these two groups was 
      not statistically significant ( p = 0.065). For early nasopharyngeal carcinoma
      patients without lymph node metastasis, overall survival and disease-free
      survival in T1 patients were superior to those in T2 patients (chi2 = 4.403, p = 
      0.036; chi2 = 4.542, p = 0.033). At the end of treatment, the pain score was
      found to be significantly lower in the surgery group than in the
      chemoradiotherapy group ( p = 0.027). At 3 months and 1 year after treatment, dry
      mouth scores were significantly lower in the surgery group than in the
      chemoradiotherapy group ( p = 0.002, p = 0.026). These results demonstrated that 
      the curative effect of surgery combined with chemoradiotherapy in the treatment
      of nasopharyngeal carcinoma was satisfactory and was particularly suitable for N0
      patients.
FAU - Si, Yong-Feng
AU  - Si YF
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Lan, Gui-Ping
AU  - Lan GP
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Deng, Zhuo-Xia
AU  - Deng ZX
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Weng, Jing-Jin
AU  - Weng JJ
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Si, Jin-Yuan
AU  - Si JY
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Qin, Yang-Da
AU  - Qin YD
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Huang, Bo
AU  - Huang B
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Wang, Yong-Li
AU  - Wang YL
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Yang, Yong
AU  - Yang Y
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Qin, Yin
AU  - Qin Y
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Zhang, Ben-Jian
AU  - Zhang BJ
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Han, Xing
AU  - Han X
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Xiong, Wei-Ming
AU  - Xiong WM
AD  - Department of Otolaryngology-Head and Neck Oncology, The People's Hospital of
      Guangxi Zhuang Autonomous Region, Nanning, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - Nasopharyngeal carcinoma
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Carcinoma/*drug therapy/pathology/*radiotherapy/*surgery
MH  - Combined Modality Therapy
MH  - Disease-Free Survival
MH  - Endoscopy
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*drug therapy/pathology/*radiotherapy/*surgery
MH  - Neoplasm Staging
MH  - Paranasal Sinuses/pathology/*surgery
MH  - Prognosis
MH  - Quality of Life
OTO - NOTNLM
OT  - Nasopharyngeal carcinoma
OT  - chemotherapy
OT  - endoscopic sinus chisurgery
OT  - prognosis
OT  - quality of life
OT  - radiotherapy
EDAT- 2017/07/18 06:00
MHDA- 2017/07/27 06:00
CRDT- 2017/07/18 06:00
AID - 10.1177/1010428317707435 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jul;39(7):1010428317707435. doi: 10.1177/1010428317707435.