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Sporamin induces apoptosis and inhibits NF-κB activation in human pancreatic cancer cells.

Abstract Sporamin, a Kunitz-type trypsin inhibitor (TI) from sweet potato tuberous roots, has demonstrated anti-tumor activity through poorly defined mechanisms. Furthermore, the effects of sporamin on pancreatic cancer have not been explored. Herein, we studied the effects of sporamin on two human pancreatic cancer cell lines, PANC-1 and BxPC-3. Sporamin significantly inhibited the cell viability and proliferation activity and induced apoptosis in PANC-1 and BxPC-3 cells. Consistently, in sporamin-treated PANC-1 and BxPC-3 cells, the anti-apoptotic proteins Bcl-2 and Bcl-XL were downregulated and the pro-apoptotic protein Bax was upregulated. Moreover, nuclear factor kappa B activation and IκBα phosphorylation were inhibited, and total IκBα expression was increased in sporamin-treated PANC-1 and BxPC-3 cells. Thus, our results suggest that the anti-tumor effects of sporamin in pancreatic cancer cells might result partly from induction of apoptosis by downregulating nuclear factor kappa B pathway.
PMID
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Authors

Mayor MeshTerms
Keywords

Sporamin

apoptosis

nuclear factor kappa B

pancreatic cancer

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28714369
OWN - NLM
STAT- MEDLINE
DA  - 20170717
DCOM- 20170726
LR  - 20170726
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 7
DP  - 2017 Jul
TI  - Sporamin induces apoptosis and inhibits NF-kappaB activation in human pancreatic 
      cancer cells.
PG  - 1010428317706917
LID - 10.1177/1010428317706917 [doi]
AB  - Sporamin, a Kunitz-type trypsin inhibitor (TI) from sweet potato tuberous roots, 
      has demonstrated anti-tumor activity through poorly defined mechanisms.
      Furthermore, the effects of sporamin on pancreatic cancer have not been explored.
      Herein, we studied the effects of sporamin on two human pancreatic cancer cell
      lines, PANC-1 and BxPC-3. Sporamin significantly inhibited the cell viability and
      proliferation activity and induced apoptosis in PANC-1 and BxPC-3 cells.
      Consistently, in sporamin-treated PANC-1 and BxPC-3 cells, the anti-apoptotic
      proteins Bcl-2 and Bcl-XL were downregulated and the pro-apoptotic protein Bax
      was upregulated. Moreover, nuclear factor kappa B activation and IkappaBalpha
      phosphorylation were inhibited, and total IkappaBalpha expression was increased
      in sporamin-treated PANC-1 and BxPC-3 cells. Thus, our results suggest that the
      anti-tumor effects of sporamin in pancreatic cancer cells might result partly
      from induction of apoptosis by downregulating nuclear factor kappa B pathway.
FAU - Qian, Cuijuan
AU  - Qian C
AD  - Institute of Tumor, School of Medicine, Taizhou University, Taizhou, Zhejiang,
      P.R. China.
FAU - Chen, Xiaoying
AU  - Chen X
AD  - Institute of Tumor, School of Medicine, Taizhou University, Taizhou, Zhejiang,
      P.R. China.
FAU - Qi, Yongxiao
AU  - Qi Y
AD  - Institute of Tumor, School of Medicine, Taizhou University, Taizhou, Zhejiang,
      P.R. China.
FAU - Zhong, Sheng
AU  - Zhong S
AD  - Institute of Tumor, School of Medicine, Taizhou University, Taizhou, Zhejiang,
      P.R. China.
FAU - Gao, Xinyan
AU  - Gao X
AD  - Institute of Tumor, School of Medicine, Taizhou University, Taizhou, Zhejiang,
      P.R. China.
FAU - Zheng, Wenjun
AU  - Zheng W
AD  - Institute of Tumor, School of Medicine, Taizhou University, Taizhou, Zhejiang,
      P.R. China.
FAU - Mao, Zhixiang
AU  - Mao Z
AD  - Institute of Tumor, School of Medicine, Taizhou University, Taizhou, Zhejiang,
      P.R. China.
FAU - Yao, Jun
AU  - Yao J
AD  - Institute of Tumor, School of Medicine, Taizhou University, Taizhou, Zhejiang,
      P.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (NF-kappa B)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Plant Proteins)
RN  - 0 (sporamin A protein, Ipomoea batatas)
SB  - IM
MH  - Apoptosis/*drug effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - NF-kappa B/genetics
MH  - Neoplasm Proteins/*genetics
MH  - Pancreatic Neoplasms/*drug therapy/genetics/pathology
MH  - Phosphorylation
MH  - Plant Proteins/*administration & dosage
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Sporamin
OT  - apoptosis
OT  - nuclear factor kappa B
OT  - pancreatic cancer
EDAT- 2017/07/18 06:00
MHDA- 2017/07/27 06:00
CRDT- 2017/07/18 06:00
AID - 10.1177/1010428317706917 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jul;39(7):1010428317706917. doi: 10.1177/1010428317706917.