PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Antibody trapping: A novel mechanism of parasite immune evasion by the trematode Echinostoma caproni.

Abstract Helminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in global health and the socioeconomic growth of developing countries. In this context, the study of helminth biology, with emphasis on host-parasite interactions, appears as a promising approach for developing new tools to prevent and control these infections.
PMID
Related Publications

Definitive host influences the proteomic profile of excretory/secretory products of the trematode Echinostoma caproni.

The effect of glycosylation of antigens on the antibody responses against Echinostoma caproni (Trematoda: Echinostomatidae).

Resistance against Echinostoma caproni (Trematoda) secondary infections in mice is not dependent on the ileal protein production.

Excretory/secretory proteome of the adult stage of Echinostoma caproni.

Echinostoma caproni in mice: ultrastructural studies on the formation of immune complexes on the surface of an intestinal trematode.

Authors

Mayor MeshTerms
Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28715423
OWN - NLM
STAT- Publisher
DA  - 20170717
LR  - 20170717
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 7
DP  - 2017 Jul 17
TI  - Antibody trapping: A novel mechanism of parasite immune evasion by the trematode 
      Echinostoma caproni.
PG  - e0005773
LID - 10.1371/journal.pntd.0005773 [doi]
AB  - BACKGROUND: Helminth infections are among the most prevalent neglected tropical
      diseases, causing an enormous impact in global health and the socioeconomic
      growth of developing countries. In this context, the study of helminth biology,
      with emphasis on host-parasite interactions, appears as a promising approach for 
      developing new tools to prevent and control these infections. METHODS/PRINCIPAL
      FINDINGS: The role that antibody responses have on helminth infections is still
      not well understood. To go in depth into this issue, work on the intestinal
      helminth Echinostoma caproni (Trematoda: Echinostomatidae) has been undertaken.
      Adult parasites were recovered from infected mice and cultured in vitro. Double
      indirect immunofluorescence at increasing culture times was done to show that in 
      vivo-bound surface antibodies become trapped within a layer of
      excretory/secretory products that covers the parasite. Entrapped antibodies are
      then degraded by parasite-derived proteases, since protease inhibitors prevent
      for antibody loss in culture. Electron microscopy and immunogold-labelling of
      secreted proteins provide evidence that this mechanism is consistent with
      tegument dynamics and ultrastructure, hence it is feasible to occur in vivo.
      Secretory vesicles discharge their content to the outside and released products
      are deposited over the parasite surface enabling antibody trapping.
      CONCLUSION/SIGNIFICANCE: At the site of infection, both parasite secretion and
      antibody binding occur simultaneously and constantly. The continuous entrapment
      of bound antibodies with newly secreted products may serve to minimize the
      deleterious effects of the antibody-mediated attack. This mechanism of immune
      evasion may aid to understand the limited effect that antibody responses have in 
      helminth infections, and may contribute to the basis for vaccine development
      against these highly prevalent diseases.
FAU - Cortes, Alba
AU  - Cortes A
AUID- ORCID: http://orcid.org/0000-0002-9027-8780
AD  - Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia,
      Burjassot, Valencia, Spain.
FAU - Sotillo, Javier
AU  - Sotillo J
AD  - Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia,
      Burjassot, Valencia, Spain.
AD  - Centre for Biodiscovery and Molecular Development of Therapeutics, Australian
      Institute of Tropical Health and Medicine, James Cook University, Cairns,
      Queensland, Australia.
FAU - Munoz-Antoli, Carla
AU  - Munoz-Antoli C
AD  - Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia,
      Burjassot, Valencia, Spain.
FAU - Molina-Duran, Javier
AU  - Molina-Duran J
AD  - Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia,
      Burjassot, Valencia, Spain.
FAU - Esteban, J Guillermo
AU  - Esteban JG
AD  - Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia,
      Burjassot, Valencia, Spain.
FAU - Toledo, Rafael
AU  - Toledo R
AD  - Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia,
      Burjassot, Valencia, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170717
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
EDAT- 2017/07/18 06:00
MHDA- 2017/07/18 06:00
CRDT- 2017/07/18 06:00
PHST- 2017/03/31 [received]
PHST- 2017/07/05 [accepted]
AID - 10.1371/journal.pntd.0005773 [doi]
AID - PNTD-D-17-00479 [pii]
PST - aheadofprint
SO  - PLoS Negl Trop Dis. 2017 Jul 17;11(7):e0005773. doi:
      10.1371/journal.pntd.0005773.