PubTransformer

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PMID- 28715582
OWN - NLM
STAT- MEDLINE
DA  - 20170717
DCOM- 20170728
LR  - 20170728
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 6
DP  - 2017 May 01
TI  - Iris Freckles a Potential Biomarker for Chronic Sun Damage.
PG  - BIO174-BIO179
LID - 10.1167/iovs.17-21751 [doi]
AB  - Purpose: To investigate the role of sunlight exposure in iris freckles formation.
      Methods: We prospectively examined volunteers attending a skin cancer screening
      program conducted by ophthalmologists and dermatologists. Frequency and
      topographical variability of iris freckles were noted and associated with
      behavioral and dermatologic characteristics indicating high sun exposure.
      Results: Six hundred thirty-two participants (n = 360; 57% female) were examined.
      Mean age of all participants was 38.4 +/- 18.4 years (range, 4-84 years). Of all 
      individuals, 76.1% (n = 481) exhibited at least one iris freckle. Most freckles
      were observed in the inferior temporal quadrant. The presence of iris freckles
      was associated with higher age (participants with iris freckles: 41.8 +/- 16.8
      years versus participants without iris freckles: 27.6 +/- 19.2 years), a high
      number of sunburns during lifetime (>10: 31% vs. 19%), sunlight-damaged skin (26%
      vs. 11%), presence of actinic lentigines (72% vs. 45%), and a high total nevus
      body count (>10; 78% vs. 67%). Conclusions: The association of iris freckles,
      behavioral factors, and dermatologic findings, as well as the topographical
      distribution, indicate that sunlight exposure may trigger the formation of iris
      freckles. The evaluation of iris freckles offers an easily accessible potential
      biomarker, which might be helpful in indicating sun damage on the skin associated
      with cutaneous malignancies. Furthermore, the evaluation of iris freckles could
      also be helpful in understanding the role of sunlight in several ophthalmologic
      diseases.
FAU - Schwab, Christoph
AU  - Schwab C
AD  - Department of Ophthalmology, Medical University of Graz, Graz, Austria.
FAU - Mayer, Christoph
AU  - Mayer C
AD  - Department of Ophthalmology, Medical University of Graz, Graz, Austria.
FAU - Zalaudek, Iris
AU  - Zalaudek I
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
FAU - Riedl, Regina
AU  - Riedl R
AD  - Institute for Medical Informatics, Statistics and Documentation, Medical
      University of Graz, Graz, Austria.
FAU - Richtig, Markus
AU  - Richtig M
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
FAU - Wackernagel, Werner
AU  - Wackernagel W
AD  - Department of Ophthalmology, Medical University of Graz, Graz, Austria.
FAU - Hofmann-Wellenhof, Rainer
AU  - Hofmann-Wellenhof R
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
FAU - Richtig, Georg
AU  - Richtig G
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
FAU - Langmann, Gerald
AU  - Langmann G
AD  - Department of Ophthalmology, Medical University of Graz, Graz, Austria.
FAU - Tarmann, Lisa
AU  - Tarmann L
AD  - Department of Ophthalmology, Medical University of Graz, Graz, Austria.
FAU - Wedrich, Andreas
AU  - Wedrich A
AD  - Department of Ophthalmology, Medical University of Graz, Graz, Austria.
FAU - Richtig, Erika
AU  - Richtig E
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/physiology
MH  - *Biomarkers
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Eye Color
MH  - Female
MH  - Humans
MH  - Iris/*radiation effects
MH  - Iris Diseases/diagnosis/*etiology
MH  - Male
MH  - Melanosis/diagnosis/*etiology
MH  - Middle Aged
MH  - Nevus, Pigmented/diagnosis/etiology
MH  - Prospective Studies
MH  - Radiation Injuries/diagnosis/*etiology
MH  - Skin/radiation effects
MH  - Skin Neoplasms/diagnosis/etiology
MH  - Sunburn/complications
MH  - Sunlight/*adverse effects
MH  - Surveys and Questionnaires
EDAT- 2017/07/18 06:00
MHDA- 2017/07/29 06:00
CRDT- 2017/07/18 06:00
AID - 2644236 [pii]
AID - 10.1167/iovs.17-21751 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO174-BIO179. doi:
      10.1167/iovs.17-21751.