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Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns.

Abstract Alkali burns are the most common, severe chemical ocular injuries, their functional prognosis depending on corneal wound healing efficiency. The purpose of our study was to compare the benefits of amniotic membrane (AM) grafts and homogenates for wound healing in the presence or absence of previous all-trans retinoic acid (atRA) treatment.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28715585
OWN - NLM
STAT- In-Process
DA  - 20170717
LR  - 20170717
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive 
      Effects on Corneal Alkali Burns.
PG  - 3513-3518
LID - 10.1167/iovs.17-21810 [doi]
AB  - Purpose: Alkali burns are the most common, severe chemical ocular injuries, their
      functional prognosis depending on corneal wound healing efficiency. The purpose
      of our study was to compare the benefits of amniotic membrane (AM) grafts and
      homogenates for wound healing in the presence or absence of previous all-trans
      retinoic acid (atRA) treatment. Methods: Fifty male CD1 mice with reproducible
      corneal chemical burn were divided into five groups, as follows: group 1 was
      treated with saline solution; groups 2 and 3 received untreated AM grafts or
      grafts treated with atRA, respectively; and groups 4 and 5 received untreated AM 
      homogenates or homogenates treated with atRA, respectively. After 7 days of
      treatment, ulcer area and depth were measured, and vascular endothelial growth
      factor (VEGF) and matrix metalloproteinase 9 (MMP-9) were quantified. Results: AM
      induction by atRA was confirmed via quantification of retinoic acid receptor beta
      (RARbeta), a well-established retinoic acid-induced gene. Significant
      improvements of corneal wound healing in terms of ulcer area and depth were
      obtained with both strategies. No major differences were found between the
      efficiency of AM homogenates and grafts. This positive action was increased when 
      AM was pretreated with atRA. Furthermore, AM induced a decrease in VEGF and MMP-9
      levels during the wound healing process. The atRA treatment led to an even
      greater decrease in the expression of both proteins. Conclusions: Amnion
      homogenate is as effective as AM grafts in promoting corneal wound healing in a
      mouse model. A higher positive effect was obtained with atRA treatment.
FAU - Joubert, Romain
AU  - Joubert R
AD  - Centre Hospitalo-Universitaire, Clermont-Ferrand, Ophthalmology Department,
      Clermont-Ferrand, France 2Translational Approach to Epithelial Injury and Repair 
      Team, Universite Clermont Auvergne, Centre National de Recherche Scientifique,
      Institut National de la Sante et de la Recherche Medicale, Genetique Reproduction
      et Developpement, Clermont-Ferrand, France.
FAU - Daniel, Estelle
AU  - Daniel E
AD  - Centre Hospitalo-Universitaire, Clermont-Ferrand, Ophthalmology Department,
      Clermont-Ferrand, France 2Translational Approach to Epithelial Injury and Repair 
      Team, Universite Clermont Auvergne, Centre National de Recherche Scientifique,
      Institut National de la Sante et de la Recherche Medicale, Genetique Reproduction
      et Developpement, Clermont-Ferrand, France.
FAU - Bonnin, Nicolas
AU  - Bonnin N
AD  - Centre Hospitalo-Universitaire, Clermont-Ferrand, Ophthalmology Department,
      Clermont-Ferrand, France 2Translational Approach to Epithelial Injury and Repair 
      Team, Universite Clermont Auvergne, Centre National de Recherche Scientifique,
      Institut National de la Sante et de la Recherche Medicale, Genetique Reproduction
      et Developpement, Clermont-Ferrand, France.
FAU - Comptour, Aurelie
AU  - Comptour A
AD  - Translational Approach to Epithelial Injury and Repair Team, Universite Clermont 
      Auvergne, Centre National de Recherche Scientifique, Institut National de la
      Sante et de la Recherche Medicale, Genetique Reproduction et Developpement,
      Clermont-Ferrand, France.
FAU - Gross, Christelle
AU  - Gross C
AD  - Translational Approach to Epithelial Injury and Repair Team, Universite Clermont 
      Auvergne, Centre National de Recherche Scientifique, Institut National de la
      Sante et de la Recherche Medicale, Genetique Reproduction et Developpement,
      Clermont-Ferrand, France.
FAU - Belville, Corinne
AU  - Belville C
AD  - Translational Approach to Epithelial Injury and Repair Team, Universite Clermont 
      Auvergne, Centre National de Recherche Scientifique, Institut National de la
      Sante et de la Recherche Medicale, Genetique Reproduction et Developpement,
      Clermont-Ferrand, France.
FAU - Chiambaretta, Frederic
AU  - Chiambaretta F
AD  - Centre Hospitalo-Universitaire, Clermont-Ferrand, Ophthalmology Department,
      Clermont-Ferrand, France 2Translational Approach to Epithelial Injury and Repair 
      Team, Universite Clermont Auvergne, Centre National de Recherche Scientifique,
      Institut National de la Sante et de la Recherche Medicale, Genetique Reproduction
      et Developpement, Clermont-Ferrand, France.
FAU - Blanchon, Loic
AU  - Blanchon L
AD  - Translational Approach to Epithelial Injury and Repair Team, Universite Clermont 
      Auvergne, Centre National de Recherche Scientifique, Institut National de la
      Sante et de la Recherche Medicale, Genetique Reproduction et Developpement,
      Clermont-Ferrand, France.
FAU - Sapin, Vincent
AU  - Sapin V
AD  - Translational Approach to Epithelial Injury and Repair Team, Universite Clermont 
      Auvergne, Centre National de Recherche Scientifique, Institut National de la
      Sante et de la Recherche Medicale, Genetique Reproduction et Developpement,
      Clermont-Ferrand, France.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
EDAT- 2017/07/18 06:00
MHDA- 2017/07/18 06:00
CRDT- 2017/07/18 06:00
AID - 2644239 [pii]
AID - 10.1167/iovs.17-21810 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3513-3518. doi:
      10.1167/iovs.17-21810.