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Malaria Infection and Gametocyte Carriage Rates in Preparation for Transmission Blocking Vaccine Trials in Bancoumana, Mali.

Abstract The epidemiological characterization of transmission reservoirs is a critical step in preparation for interventional trials for malaria elimination/eradication. Using cluster sampling and households/compounds as units of sampling, we recruited and followed monthly, from June 2011 to June 2012, 250 volunteers 3 months to 50 years of age in Bancoumana, Mali. In July 2012, only participants 5-35 years of age (N = 121) were reenrolled and followed for an additional year. Malaria infection prevalence was highest in October in both 2011 (21.5%, 50/233) and 2012 (38.2%, 26/68). During both years, malaria infection prevalence was highest in children 5-14 years of age (P = 0.01 and P = 0.02, respectively). The gametocyte carriage prevalence was highest in November 2011 (7.6%, 17/225) and in October 2012 (16.2%, 11/68). Gametocyte carriage rates by age did not significantly differ in 2011 and 2012. In Bancoumana, the asexual and sexual parasite carriage rates are relatively high and highly seasonal. Seasonal variation and age differences in parasite and gametocyte carriage provide essential knowledge for the design of transmission blocking assay and vaccine studies in the field.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the american journal of tropical medicine and hygiene
Publication Year Start




PMID- 28719292
OWN - NLM
STAT- MEDLINE
DA  - 20170718
DCOM- 20170731
LR  - 20170731
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 1
DP  - 2017 Jul
TI  - Malaria Infection and Gametocyte Carriage Rates in Preparation for Transmission
      Blocking Vaccine Trials in Bancoumana, Mali.
PG  - 183-187
LID - 10.4269/ajtmh.15-0845 [doi]
AB  - The epidemiological characterization of transmission reservoirs is a critical
      step in preparation for interventional trials for malaria
      elimination/eradication. Using cluster sampling and households/compounds as units
      of sampling, we recruited and followed monthly, from June 2011 to June 2012, 250 
      volunteers 3 months to 50 years of age in Bancoumana, Mali. In July 2012, only
      participants 5-35 years of age (N = 121) were reenrolled and followed for an
      additional year. Malaria infection prevalence was highest in October in both 2011
      (21.5%, 50/233) and 2012 (38.2%, 26/68). During both years, malaria infection
      prevalence was highest in children 5-14 years of age (P = 0.01 and P = 0.02,
      respectively). The gametocyte carriage prevalence was highest in November 2011
      (7.6%, 17/225) and in October 2012 (16.2%, 11/68). Gametocyte carriage rates by
      age did not significantly differ in 2011 and 2012. In Bancoumana, the asexual and
      sexual parasite carriage rates are relatively high and highly seasonal. Seasonal 
      variation and age differences in parasite and gametocyte carriage provide
      essential knowledge for the design of transmission blocking assay and vaccine
      studies in the field.
FAU - Assadou, Mahamadoun Hamady
AU  - Assadou MH
AD  - Malaria Research and Training Center, FMOS-FAPH, Mali-NIAID-ICER, University of
      Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
FAU - Sagara, Issaka
AU  - Sagara I
AD  - Malaria Research and Training Center, FMOS-FAPH, Mali-NIAID-ICER, University of
      Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
FAU - Healy, Sara A
AU  - Healy SA
AD  - Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy
      and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
FAU - Guindo, Merepen Agnes
AU  - Guindo MA
AD  - Malaria Research and Training Center, FMOS-FAPH, Mali-NIAID-ICER, University of
      Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
FAU - Kone, Mamady
AU  - Kone M
AD  - Malaria Research and Training Center, FMOS-FAPH, Mali-NIAID-ICER, University of
      Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
FAU - Sanogo, Sintry
AU  - Sanogo S
AD  - Malaria Research and Training Center, FMOS-FAPH, Mali-NIAID-ICER, University of
      Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
FAU - Doucoure, M'Bouye
AU  - Doucoure M
AD  - Malaria Research and Training Center, FMOS-FAPH, Mali-NIAID-ICER, University of
      Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
FAU - Keita, Sekouba
AU  - Keita S
AD  - Malaria Research and Training Center, FMOS-FAPH, Mali-NIAID-ICER, University of
      Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
FAU - Ellis, Ruth D
AU  - Ellis RD
AD  - Biologics Consulting Group Inc., Alexandria, Virginia.
FAU - Wu, Yimin
AU  - Wu Y
AD  - PATH-Malaria Vaccine Initiative, Washington, District of Columbia.
FAU - Omaswa, Freda
AU  - Omaswa F
AD  - University of British Columbia, Vancouver, Canada.
FAU - Duffy, Patrick E
AU  - Duffy PE
AD  - Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy
      and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
FAU - Doumbo, Ogobara K
AU  - Doumbo OK
AD  - Malaria Research and Training Center, FMOS-FAPH, Mali-NIAID-ICER, University of
      Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Malaria Vaccines)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Clinical Trials as Topic
MH  - Female
MH  - Humans
MH  - Infant
MH  - Malaria Vaccines
MH  - Malaria, Falciparum/*epidemiology/*parasitology/prevention & control
MH  - Male
MH  - Mali/epidemiology
MH  - Middle Aged
MH  - Young Adult
PMC - PMC5508881
EDAT- 2017/07/19 06:00
MHDA- 2017/08/02 06:00
CRDT- 2017/07/19 06:00
PMCR- 2018/07/12
AID - 10.4269/ajtmh.15-0845 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Jul;97(1):183-187. doi: 10.4269/ajtmh.15-0845.