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Molecular Epidemiology of Malaria in Cameroon and Côte d'Ivoire. XXXI. Kelch 13 Propeller Sequences in Plasmodium falciparum Isolates before and after Implementation of Artemisinin-Based Combination Therapy.

Abstract Artemisinin-resistant malaria has not been reported from Africa, but resistance can possibly spread from Asia or arise independently in Africa. The emergence of artemisinin resistance in Africa can be monitored by molecular assay of Kelch 13 (K13) propeller sequences. A total of 251 archived DNA samples of Plasmodium falciparum isolates collected in 2002, 2003, and 2006 in Yaounde, Cameroon, and 47 samples collected in 2006 and 2013 in Abidjan, Côte d'Ivoire, were analyzed for K13-propeller sequence polymorphism. Only one isolate carried a mutant K13-propeller allele (E602D). None of the isolates carried the key mutant alleles (Y493H, R539T, I543T, and C580Y) associated with artemisinin resistance in Cambodia. The presence of the mutant allele was not correlated with in vitro response to dihydroartemisinin determined by the classical hypoxanthine incorporation assay. There was no evidence of K13 mutations associated with artemisinin resistance before and soon after the introduction of artemisinin-based combination therapies in Cameroon and Côte d'Ivoire.
PMID
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Authors

Mayor MeshTerms

Molecular Epidemiology

Keywords
Journal Title the american journal of tropical medicine and hygiene
Publication Year Start




PMID- 28719312
OWN - NLM
STAT- MEDLINE
DA  - 20170718
DCOM- 20170731
LR  - 20170731
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 1
DP  - 2017 Jul
TI  - Molecular Epidemiology of Malaria in Cameroon and Cote d'Ivoire. XXXI. Kelch 13
      Propeller Sequences in Plasmodium falciparum Isolates before and after
      Implementation of Artemisinin-Based Combination Therapy.
PG  - 222-224
LID - 10.4269/ajtmh.16-0889 [doi]
AB  - Artemisinin-resistant malaria has not been reported from Africa, but resistance
      can possibly spread from Asia or arise independently in Africa. The emergence of 
      artemisinin resistance in Africa can be monitored by molecular assay of Kelch 13 
      (K13) propeller sequences. A total of 251 archived DNA samples of Plasmodium
      falciparum isolates collected in 2002, 2003, and 2006 in Yaounde, Cameroon, and
      47 samples collected in 2006 and 2013 in Abidjan, Cote d'Ivoire, were analyzed
      for K13-propeller sequence polymorphism. Only one isolate carried a mutant
      K13-propeller allele (E602D). None of the isolates carried the key mutant alleles
      (Y493H, R539T, I543T, and C580Y) associated with artemisinin resistance in
      Cambodia. The presence of the mutant allele was not correlated with in vitro
      response to dihydroartemisinin determined by the classical hypoxanthine
      incorporation assay. There was no evidence of K13 mutations associated with
      artemisinin resistance before and soon after the introduction of
      artemisinin-based combination therapies in Cameroon and Cote d'Ivoire.
FAU - Djaman, Joseph Allico
AU  - Djaman JA
AD  - Departement de Parasitologie-Mycologie, Institut Pasteur de Cote d'Ivoire,
      Abidjan, Cote d'Ivoire.
AD  - Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Universite Felix
      Houphouet-Boigny, Abidjan, Cote d'Ivoire.
FAU - Olefongo, Dagnogo
AU  - Olefongo D
AD  - Departement de Parasitologie-Mycologie, Institut Pasteur de Cote d'Ivoire,
      Abidjan, Cote d'Ivoire.
AD  - Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Universite Felix
      Houphouet-Boigny, Abidjan, Cote d'Ivoire.
FAU - Ako, Aristide Berenger
AU  - Ako AB
AD  - Departement de Parasitologie-Mycologie, Institut Pasteur de Cote d'Ivoire,
      Abidjan, Cote d'Ivoire.
AD  - Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Universite Felix
      Houphouet-Boigny, Abidjan, Cote d'Ivoire.
FAU - Roman, Jocelyne
AU  - Roman J
AD  - PRES Sorbonne Paris Cite, Universite Paris Descartes Faculte de Pharmacie, Paris,
      France.
AD  - Unite Mixte de la Recherche 216, Mere et Enfant Face aux Infections Tropicales,
      Institut de Recherche pour le Developpement (IRD), Unite de Formation et de
      Recherche (UFR) de Pharmacie, Universite Paris Descartes, Paris, France.
FAU - Ngane, Vincent Foumane
AU  - Ngane VF
AD  - Organisation de Coordination pour la lutte contre les Endemies en Afrique
      Centrale (OCEAC), Yaounde, Cameroon.
FAU - Basco, Leonardo K
AU  - Basco LK
AD  - Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
      (URMITE), Aix-Marseille Universite, Institut Hospitalo-Universitaire Mediterranee
      Infection, Marseille, France.
AD  - Organisation de Coordination pour la lutte contre les Endemies en Afrique
      Centrale (OCEAC), Yaounde, Cameroon.
FAU - Tahar, Rachida
AU  - Tahar R
AD  - PRES Sorbonne Paris Cite, Universite Paris Descartes Faculte de Pharmacie, Paris,
      France.
AD  - Organisation de Coordination pour la lutte contre les Endemies en Afrique
      Centrale (OCEAC), Yaounde, Cameroon.
AD  - Unite Mixte de la Recherche 216, Mere et Enfant Face aux Infections Tropicales,
      Institut de Recherche pour le Developpement (IRD), Unite de Formation et de
      Recherche (UFR) de Pharmacie, Universite Paris Descartes, Paris, France.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antimalarials)
RN  - 0 (Artemisinins)
RN  - 0 (Protozoan Proteins)
RN  - 9RMU91N5K2 (artemisinine)
SB  - AIM
SB  - IM
MH  - Antimalarials/therapeutic use
MH  - Artemisinins/*therapeutic use
MH  - Cameroon/epidemiology
MH  - Cote d'Ivoire/epidemiology
MH  - Gene Expression Regulation/*drug effects
MH  - Humans
MH  - Malaria, Falciparum/drug therapy/*parasitology
MH  - *Molecular Epidemiology
MH  - Plasmodium falciparum/*genetics
MH  - Protozoan Proteins/genetics/*metabolism
MH  - Time Factors
PMC - PMC5508902
EDAT- 2017/07/19 06:00
MHDA- 2017/08/02 06:00
CRDT- 2017/07/19 06:00
PMCR- 2018/07/12
AID - 10.4269/ajtmh.16-0889 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Jul;97(1):222-224. doi: 10.4269/ajtmh.16-0889.