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Serologic Monitoring of Public Health Interventions against Strongyloides stercoralis.

Abstract Northwestern Argentina is endemic for soil-transmitted helminths, and annual deworming programs are carried out in prioritized areas. High prevalence of Strongyloides stercoralis was reported in this area; therefore, control programs including ivermectin are being evaluated. The NIE-enzyme linked immunosorbent assay (ELISA) was used for this purpose. In this community trial, two groups of patients, classified according to housing and living conditions were evaluated. Simultaneous with baseline survey, Group 1 was moved to new households with access to improved water and sanitation facilities (W and S), where deworming (MDA, massive drug administration) took place within 1 month; whereas Group 2 received MDA but remained living with unimproved W and S. The mean time interval between baseline and the follow-up was 331 days for Group 1 and 508 for Group 2. Anti-NIE levels were measured for each individual before and after interventions and follow-up optical density (OD) ratios were calculated to quantify the variation. A significant decrease of the anti-NIE levels between baseline and follow-up was observed in both groups. Nonetheless, the number of patients that achieved the cure criteria (OD ratio < 0.6) was higher in Group 1 than Group 2 with values of 72.7% (24/33) and 45.0% (18/40), respectively (P = 0.0197). Our results support the conclusion that a combined intervention including deworming and improvements in life conditions is more effective, in terms of the proportion of subjects cured than deworming alone. Furthermore, we found that NIE-ELISA is a useful test for assessing the response to treatment and to evaluate the outcome of control intervention programs.
PMID
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Authors

Mayor MeshTerms

Seroepidemiologic Studies

Strongyloides stercoralis

Keywords
Journal Title the american journal of tropical medicine and hygiene
Publication Year Start




PMID- 28719325
OWN - NLM
STAT- MEDLINE
DA  - 20170718
DCOM- 20170731
LR  - 20170731
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 1
DP  - 2017 Jul
TI  - Serologic Monitoring of Public Health Interventions against Strongyloides
      stercoralis.
PG  - 166-172
LID - 10.4269/ajtmh.16-0857 [doi]
AB  - Northwestern Argentina is endemic for soil-transmitted helminths, and annual
      deworming programs are carried out in prioritized areas. High prevalence of
      Strongyloides stercoralis was reported in this area; therefore, control programs 
      including ivermectin are being evaluated. The NIE-enzyme linked immunosorbent
      assay (ELISA) was used for this purpose. In this community trial, two groups of
      patients, classified according to housing and living conditions were evaluated.
      Simultaneous with baseline survey, Group 1 was moved to new households with
      access to improved water and sanitation facilities (W and S), where deworming
      (MDA, massive drug administration) took place within 1 month; whereas Group 2
      received MDA but remained living with unimproved W and S. The mean time interval 
      between baseline and the follow-up was 331 days for Group 1 and 508 for Group 2. 
      Anti-NIE levels were measured for each individual before and after interventions 
      and follow-up optical density (OD) ratios were calculated to quantify the
      variation. A significant decrease of the anti-NIE levels between baseline and
      follow-up was observed in both groups. Nonetheless, the number of patients that
      achieved the cure criteria (OD ratio &lt; 0.6) was higher in Group 1 than Group 2
      with values of 72.7% (24/33) and 45.0% (18/40), respectively (P = 0.0197). Our
      results support the conclusion that a combined intervention including deworming
      and improvements in life conditions is more effective, in terms of the proportion
      of subjects cured than deworming alone. Furthermore, we found that NIE-ELISA is a
      useful test for assessing the response to treatment and to evaluate the outcome
      of control intervention programs.
FAU - Vargas, Paola
AU  - Vargas P
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos
      Aires, Argentina.
AD  - Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad
      Nacional de Salta, Sede Regional Oran, Salta, Argentina.
FAU - Krolewiecki, Alejandro J
AU  - Krolewiecki AJ
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos
      Aires, Argentina.
AD  - Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad
      Nacional de Salta, Sede Regional Oran, Salta, Argentina.
FAU - Echazu, Adriana
AU  - Echazu A
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos
      Aires, Argentina.
AD  - Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad
      Nacional de Salta, Sede Regional Oran, Salta, Argentina.
FAU - Juarez, Marisa
AU  - Juarez M
AD  - Fundacion Mundo Sano, Buenos Aires, Argentina.
AD  - Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad
      Nacional de Salta, Sede Regional Oran, Salta, Argentina.
FAU - Cajal, Pamela
AU  - Cajal P
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos
      Aires, Argentina.
FAU - Gil, Jose F
AU  - Gil JF
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos
      Aires, Argentina.
AD  - Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad
      Nacional de Salta, Sede Regional Oran, Salta, Argentina.
FAU - Caro, Nicolas
AU  - Caro N
AD  - Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad
      Nacional de Salta, Sede Regional Oran, Salta, Argentina.
FAU - Nasser, Julio
AU  - Nasser J
AD  - Catedra de Quimica Biologica, Universidad Nacional de Salta (UNSa), Salta,
      Argentina.
AD  - Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad
      Nacional de Salta, Sede Regional Oran, Salta, Argentina.
FAU - Lammie, Patrick
AU  - Lammie P
AD  - Centers for Disease Control and Prevention, Atlanta, Georgia.
FAU - Cimino, Ruben O
AU  - Cimino RO
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos
      Aires, Argentina.
AD  - Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad
      Nacional de Salta, Sede Regional Oran, Salta, Argentina.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Anthelmintics)
RN  - 0 (Antibodies, Helminth)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Anthelmintics/*therapeutic use
MH  - Antibodies, Helminth/blood
MH  - Argentina/epidemiology
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Public Health/*methods
MH  - *Seroepidemiologic Studies
MH  - *Strongyloides stercoralis
MH  - Strongyloidiasis/*drug therapy/epidemiology/*prevention &amp; control
PMC - PMC5508900
EDAT- 2017/07/19 06:00
MHDA- 2017/08/02 06:00
CRDT- 2017/07/19 06:00
PMCR- 2018/07/12
AID - 10.4269/ajtmh.16-0857 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Jul;97(1):166-172. doi: 10.4269/ajtmh.16-0857.