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Case Report: Microcephaly in Twins due to the Zika Virus.

Abstract Recent studies have demonstrated an association between congenital Zika virus (ZIKV) infection and microcephaly; however, to date, there have been no reports on the consequences of ZIKV infection on fetuses in twin pregnancies. Herein, we reported on the first case of a monochorionic diamniotic (MCDA) twin pregnancy having ZIKV-related microcephaly. Our findings suggested that, in an MCDA twin pregnancy, the ZIKV may cause infection in both fetuses, resulting in severe abnormalities in the central nervous system due to neural cell destruction and the disruption of the normal development processes of the brain. This case report and other similar twin cases may help to understand the pathogenesis and to confirm the etiology of ZIKV as a teratogenic microorganism.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the american journal of tropical medicine and hygiene
Publication Year Start




PMID- 28719330
OWN - NLM
STAT- MEDLINE
DA  - 20170718
DCOM- 20170731
LR  - 20170731
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 1
DP  - 2017 Jul
TI  - Case Report: Microcephaly in Twins due to the Zika Virus.
PG  - 151-154
LID - 10.4269/ajtmh.16-1021 [doi]
AB  - Recent studies have demonstrated an association between congenital Zika virus
      (ZIKV) infection and microcephaly; however, to date, there have been no reports
      on the consequences of ZIKV infection on fetuses in twin pregnancies. Herein, we 
      reported on the first case of a monochorionic diamniotic (MCDA) twin pregnancy
      having ZIKV-related microcephaly. Our findings suggested that, in an MCDA twin
      pregnancy, the ZIKV may cause infection in both fetuses, resulting in severe
      abnormalities in the central nervous system due to neural cell destruction and
      the disruption of the normal development processes of the brain. This case report
      and other similar twin cases may help to understand the pathogenesis and to
      confirm the etiology of ZIKV as a teratogenic microorganism.
FAU - Santos, Victor S
AU  - Santos VS
AD  - Federal University of Sergipe, Aracaju, Brazil.
FAU - Oliveira, Sheila J G
AU  - Oliveira SJG
AD  - Federal University of Sergipe, Aracaju, Brazil.
FAU - Gurgel, Ricardo Q
AU  - Gurgel RQ
AD  - Federal University of Sergipe, Aracaju, Brazil.
FAU - Lima, Dorothy R R
AU  - Lima DRR
AD  - Federal University of Sergipe, Aracaju, Brazil.
FAU - Dos Santos, Cliomar A
AU  - Dos Santos CA
AD  - Central Public Health Laboratory, Aracaju, Brazil.
FAU - Martins-Filho, Paulo R S
AU  - Martins-Filho PRS
AD  - Federal University of Sergipe, Aracaju, Brazil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Diseases in Twins/*virology
MH  - Exotropia/congenital/etiology/pathology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Microcephaly/*virology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*virology
MH  - Zika Virus Infection/*complications/congenital
PMC - PMC5508915
EDAT- 2017/07/19 06:00
MHDA- 2017/08/02 06:00
CRDT- 2017/07/19 06:00
PMCR- 2018/07/12
AID - 10.4269/ajtmh.16-1021 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Jul;97(1):151-154. doi: 10.4269/ajtmh.16-1021.