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STYK1 promotes Warburg effect through PI3K/AKT signaling and predicts a poor prognosis in nasopharyngeal carcinoma.

Abstract STYK1 (Serine/threonine/tyrosine kinase 1), a member of the receptor tyrosine kinase family, exhibits tumorigenicity in many types of cancers. Our study reveals the important role played by STYK1 in nasopharyngeal carcinoma. STYK1 is upregulated in nasopharyngeal carcinoma tissues compared with para-carcinoma. Knockdown of STYK1 inhibits nasopharyngeal carcinoma cell proliferation, migration, and invasion, while ectopic STYK1 expression significantly promoted cell proliferation, migration, and invasion abilities. In addition, we provided lines of evidence supporting the critical role of STYK1 in the regulation of glycolysis via activation of phosphoinositide 3-kinase/AKT pathway. Survival analysis reveals that STYK1 level is an independent prognostic factor for nasopharyngeal carcinoma patients. Our results indicate that STYK1 is a promising therapeutic target in nasopharyngeal carcinoma.
PMID
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Authors

Mayor MeshTerms
Keywords

AKT

Nasopharyngeal carcinoma

glycolysis

serine/threonine/tyrosine kinase

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28720063
OWN - NLM
STAT- MEDLINE
DA  - 20170719
DCOM- 20170726
LR  - 20170726
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 7
DP  - 2017 Jul
TI  - STYK1 promotes Warburg effect through PI3K/AKT signaling and predicts a poor
      prognosis in nasopharyngeal carcinoma.
PG  - 1010428317711644
LID - 10.1177/1010428317711644 [doi]
AB  - STYK1 (Serine/threonine/tyrosine kinase 1), a member of the receptor tyrosine
      kinase family, exhibits tumorigenicity in many types of cancers. Our study
      reveals the important role played by STYK1 in nasopharyngeal carcinoma. STYK1 is 
      upregulated in nasopharyngeal carcinoma tissues compared with para-carcinoma.
      Knockdown of STYK1 inhibits nasopharyngeal carcinoma cell proliferation,
      migration, and invasion, while ectopic STYK1 expression significantly promoted
      cell proliferation, migration, and invasion abilities. In addition, we provided
      lines of evidence supporting the critical role of STYK1 in the regulation of
      glycolysis via activation of phosphoinositide 3-kinase/AKT pathway. Survival
      analysis reveals that STYK1 level is an independent prognostic factor for
      nasopharyngeal carcinoma patients. Our results indicate that STYK1 is a promising
      therapeutic target in nasopharyngeal carcinoma.
FAU - Zhao, Yunfei
AU  - Zhao Y
AD  - Department of Pathology, Suining Central Hospital, Suining, P.R. China.
FAU - Yang, Ling
AU  - Yang L
AD  - Department of Pathology, Suining Central Hospital, Suining, P.R. China.
FAU - He, Jiao
AU  - He J
AD  - Department of Pathology, Suining Central Hospital, Suining, P.R. China.
FAU - Yang, Huai
AU  - Yang H
AD  - Department of Pathology, Suining Central Hospital, Suining, P.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (STYK1 protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - Nasopharyngeal carcinoma
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/*genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*genetics/pathology
MH  - Neoplasm Invasiveness/genetics
MH  - Phosphatidylinositol 3-Kinases/genetics
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-akt/genetics
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Signal Transduction
OTO - NOTNLM
OT  - AKT
OT  - Nasopharyngeal carcinoma
OT  - glycolysis
OT  - serine/threonine/tyrosine kinase
EDAT- 2017/07/20 06:00
MHDA- 2017/07/27 06:00
CRDT- 2017/07/20 06:00
AID - 10.1177/1010428317711644 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jul;39(7):1010428317711644. doi: 10.1177/1010428317711644.