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Branched-chain amino acid, meat intake and risk of type 2 diabetes in the Women's Health Initiative.

Abstract Knowledge regarding association of dietary branched-chain amino acid (BCAA) and type 2 diabetes (T2D), and the contribution of BCAA from meat to the risk of T2D are scarce. We evaluated associations between dietary BCAA intake, meat intake, interaction between BCAA and meat intake and risk of T2D. Data analyses were performed for 74 155 participants aged 50-79 years at baseline from the Women's Health Initiative for up to 15 years of follow-up. We excluded from analysis participants with treated T2D, and factors potentially associated with T2D or missing covariate data. The BCAA and total meat intake was estimated from FFQ. Using Cox proportional hazards models, we assessed the relationship between BCAA intake, meat intake, and T2D, adjusting for confounders. A 20 % increment in total BCAA intake (g/d and %energy) was associated with a 7 % higher risk for T2D (hazard ratio (HR) 1·07; 95 % CI 1·05, 1·09). For total meat intake, a 20 % increment was associated with a 4 % higher risk of T2D (HR 1·04; 95 % CI 1·03, 1·05). The associations between BCAA intake and T2D were attenuated but remained significant after adjustment for total meat intake. These relations did not materially differ with or without adjustment for BMI. Our results suggest that dietary BCAA and meat intake are positively associated with T2D among postmenopausal women. The association of BCAA and diabetes risk was attenuated but remained positive after adjustment for meat intake suggesting that BCAA intake in part but not in full is contributing to the association of meat with T2D risk.
PMID
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Authors

Mayor MeshTerms
Keywords

BCAA branched-chain amino acid

CT clinical trial

HR hazard ratios

NBS Nutritional Biomarkers Study

OS observational study

T2D type 2 diabetes

WHI Women’s Health Initiative

Branched chained amino acids

Dietary protein intake

Meat intake

Type 2 diabetes

Journal Title the british journal of nutrition
Publication Year Start




PMID- 28721839
OWN - NLM
STAT- In-Process
DA  - 20170719
LR  - 20170719
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 117
IP  - 11
DP  - 2017 Jun
TI  - Branched-chain amino acid, meat intake and risk of type 2 diabetes in the Women's
      Health Initiative.
PG  - 1523-1530
LID - 10.1017/S0007114517001568 [doi]
AB  - Knowledge regarding association of dietary branched-chain amino acid (BCAA) and
      type 2 diabetes (T2D), and the contribution of BCAA from meat to the risk of T2D 
      are scarce. We evaluated associations between dietary BCAA intake, meat intake,
      interaction between BCAA and meat intake and risk of T2D. Data analyses were
      performed for 74 155 participants aged 50-79 years at baseline from the Women's
      Health Initiative for up to 15 years of follow-up. We excluded from analysis
      participants with treated T2D, and factors potentially associated with T2D or
      missing covariate data. The BCAA and total meat intake was estimated from FFQ.
      Using Cox proportional hazards models, we assessed the relationship between BCAA 
      intake, meat intake, and T2D, adjusting for confounders. A 20 % increment in
      total BCAA intake (g/d and %energy) was associated with a 7 % higher risk for T2D
      (hazard ratio (HR) 1.07; 95 % CI 1.05, 1.09). For total meat intake, a 20 %
      increment was associated with a 4 % higher risk of T2D (HR 1.04; 95 % CI 1.03,
      1.05). The associations between BCAA intake and T2D were attenuated but remained 
      significant after adjustment for total meat intake. These relations did not
      materially differ with or without adjustment for BMI. Our results suggest that
      dietary BCAA and meat intake are positively associated with T2D among
      postmenopausal women. The association of BCAA and diabetes risk was attenuated
      but remained positive after adjustment for meat intake suggesting that BCAA
      intake in part but not in full is contributing to the association of meat with
      T2D risk.
FAU - Isanejad, Masoud
AU  - Isanejad M
AD  - 1Institute of Public Health and Clinical Nutrition,University of Eastern
      Finland,Kuopio,Finland.
FAU - LaCroix, Andrea Z
AU  - LaCroix AZ
AD  - 2Department of Family Medicine and Public Health,University of California San
      Diego,San Diego, CA,USA.
FAU - Thomson, Cynthia A
AU  - Thomson CA
AD  - 3Department of Health Promotion Sciences, Mel and Enid Zuckerman College of
      Public Health,University of Arizona, Tucson,AZ,USA.
FAU - Tinker, Lesley
AU  - Tinker L
AD  - 4Division of Public Health Sciences,Fred Hutchinson Cancer Research
      Center,Seattle,WA,USA.
FAU - Larson, Joseph C
AU  - Larson JC
AD  - 4Division of Public Health Sciences,Fred Hutchinson Cancer Research
      Center,Seattle,WA,USA.
FAU - Qi, Qibin
AU  - Qi Q
AD  - 5Department of Epidemiology and Population Health,Albert Einstein College of
      Medicine,Bronx,NY,USA.
FAU - Qi, Lihong
AU  - Qi L
AD  - 6Department of Public Health Sciences,Division of Biostatistics,University of
      California, Davis,Davis,CA,USA.
FAU - Cooper-DeHoff, Rhonda M
AU  - Cooper-DeHoff RM
AD  - 7Pharmacotherapy and Translational Research,College of Pharmacy, University of
      Florida,Gainesville,FL,USA.
FAU - Phillips, Lawrence S
AU  - Phillips LS
AD  - 8Atlanta VA Medical Center,Decatur,GA,USA.
FAU - Prentice, Ross L
AU  - Prentice RL
AD  - 4Division of Public Health Sciences,Fred Hutchinson Cancer Research
      Center,Seattle,WA,USA.
FAU - Beasley, Jeannette M
AU  - Beasley JM
AD  - 10Division of General Internal Medicine and Clinical Innovation,New York
      University School of Medicine,New York,NY,USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
OTO - NOTNLM
OT  - BCAA branched-chain amino acid
OT  - CT clinical trial
OT  - HR hazard ratios
OT  - NBS Nutritional Biomarkers Study
OT  - OS observational study
OT  - T2D type 2 diabetes
OT  - WHI Women's Health Initiative
OT  - Branched chained amino acids
OT  - Dietary protein intake
OT  - Meat intake
OT  - Type 2 diabetes
EDAT- 2017/07/20 06:00
MHDA- 2017/07/20 06:00
CRDT- 2017/07/20 06:00
AID - S0007114517001568 [pii]
AID - 10.1017/S0007114517001568 [doi]
PST - ppublish
SO  - Br J Nutr. 2017 Jun;117(11):1523-1530. doi: 10.1017/S0007114517001568.