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Tumor necrosis factor alpha-238G/A polymorphism and risk of breast cancer: An update by meta-analysis.

Abstract The association between the tumor necrosis factor-alpha gene (TNF-a) -238G/A polymorphism and the breast cancer has been analyzed in several studies, but the results have been inconclusive. We then performed a meta-analysis to get a precise estimation of the association.
PMID
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Association between the tumor necrosis factor alpha gene -308G> A polymorphism and the risk of breast cancer: a meta-analysis.

Authors

Mayor MeshTerms

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Keywords
Journal Title medicine
Publication Year Start




PMID- 28723753
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170728
LR  - 20170728
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 29
DP  - 2017 Jul
TI  - Tumor necrosis factor alpha-238G/A polymorphism and risk of breast cancer: An
      update by meta-analysis.
PG  - e7442
LID - 10.1097/MD.0000000000007442 [doi]
AB  - BACKGROUND: The association between the tumor necrosis factor-alpha gene (TNF-a) 
      -238G/A polymorphism and the breast cancer has been analyzed in several studies, 
      but the results have been inconclusive. We then performed a meta-analysis to get 
      a precise estimation of the association. METHODS: Eight case-control studies with
      a total of 37,257 cases and 39,564 controls were identified by searching the ISI 
      Web of Knowledge database and the PubMed database up to August 2014. RESULTS:
      Overall, no association was found between TNF-alpha-238G/A polymorphism and
      breast cancer in any of genetic model (additive model OR = 1.06, 95%CI:
      0.94-1.21, Pheterogeneity = .02; homozygous model OR = 1.04, 95%CI: 0.83-1.30,
      Pheterogeneity = .98; dominant model OR = 1.06, 95%CI: 0.92-1.21, Pheterogeneity 
      = .01; recessive model OR = 1.04, 95%CI: 0.83-1.30, Pheterogeneity = .98).
      Furthermore, no significant association was identified when stratified by
      ethnicity (Caucasian, Asian). CONCLUSION: This meta-analysis indicated that the
      TNF-alpha-238G/A polymorphism is not associated with breast cancer risk in the
      overall population.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - aCentral Laboratory bDepartment of Interventional Therapy, Affiliated Zhongshan
      Hospital of Dalian University, Dalian, Liaoning Province, China.
FAU - Zhao, Guang Sheng
AU  - Zhao GS
FAU - Yuan, Xiao Lin
AU  - Yuan XL
FAU - Li, Xiao Huan
AU  - Li XH
FAU - Yang, Zhen
AU  - Yang Z
FAU - Cui, Yi Fen
AU  - Cui YF
FAU - Guan, Qing Lin
AU  - Guan QL
FAU - Sun, Xiu Yan
AU  - Sun XY
FAU - Shen, Wan
AU  - Shen W
FAU - Xu, Tai An
AU  - Xu TA
FAU - Wang, Qiu Shi
AU  - Wang QS
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - AIM
SB  - IM
MH  - Breast Neoplasms/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2017/07/21 06:00
MHDA- 2017/07/29 06:00
CRDT- 2017/07/21 06:00
AID - 10.1097/MD.0000000000007442 [doi]
AID - 00005792-201707210-00018 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(29):e7442. doi: 10.1097/MD.0000000000007442.