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Assessment of optic disc and ganglion cell layer in diabetes mellitus type 2.

Abstract The purpose of this study was to compare the optic disc parameters, retinal nerve fiber (RNFL), and macular ganglion cell layers between patients with diabetes mellitus (DM) type 2 and healthy controls.In this cross-sectional study, 69 eyes of 69 diabetic patients without diabetic retinopathy and 47 eyes of 47 healthy controls were included. Optic disc parameters (i.e., rim area, disc area, cup to disc ratio, cup volume), RNFL, and macular ganglion cell-inner plexiform layers (GCL + IPL) thickness were measured by means of spectral domain optical coherence tomography.There were not statistically significant differences between the diabetic patients and healthy controls in terms of RNFL thickness (P = .32), rim area (P = .20), disc area (P = .16), cup volume (P = .12), and average macular GCL + IPL thickness (P = .11). Nevertheless, binocular RNFL thickness symmetry percentage (P =.03), average cup to disc ratio (P = .02), and superior-nasal macular GCL + IPL thickness (P = .04) were statistically significantly different in the diabetic and control groups.Diabetic patients without retinopathy have more binocular RNFL thickness asymmetry, higher cup to disc ratio, and thinner sectoral macular GCL + IPL when compared to healthy controls. Our results may support the statement that DM causes inner retinal neurodegenerative changes.
PMID
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Authors

Mayor MeshTerms

Retinal Ganglion Cells

Keywords
Journal Title medicine
Publication Year Start




PMID- 28723781
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170808
LR  - 20170808
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 29
DP  - 2017 Jul
TI  - Assessment of optic disc and ganglion cell layer in diabetes mellitus type 2.
PG  - e7556
LID - 10.1097/MD.0000000000007556 [doi]
AB  - The purpose of this study was to compare the optic disc parameters, retinal nerve
      fiber (RNFL), and macular ganglion cell layers between patients with diabetes
      mellitus (DM) type 2 and healthy controls.In this cross-sectional study, 69 eyes 
      of 69 diabetic patients without diabetic retinopathy and 47 eyes of 47 healthy
      controls were included. Optic disc parameters (i.e., rim area, disc area, cup to 
      disc ratio, cup volume), RNFL, and macular ganglion cell-inner plexiform layers
      (GCL + IPL) thickness were measured by means of spectral domain optical coherence
      tomography.There were not statistically significant differences between the
      diabetic patients and healthy controls in terms of RNFL thickness (P = .32), rim 
      area (P = .20), disc area (P = .16), cup volume (P = .12), and average macular
      GCL + IPL thickness (P = .11). Nevertheless, binocular RNFL thickness symmetry
      percentage (P =.03), average cup to disc ratio (P = .02), and superior-nasal
      macular GCL + IPL thickness (P = .04) were statistically significantly different 
      in the diabetic and control groups.Diabetic patients without retinopathy have
      more binocular RNFL thickness asymmetry, higher cup to disc ratio, and thinner
      sectoral macular GCL + IPL when compared to healthy controls. Our results may
      support the statement that DM causes inner retinal neurodegenerative changes.
FAU - Pekel, Evre
AU  - Pekel E
AD  - aDenizli State Hospital, Eye Clinic bOphthalmology Department, Pamukkale
      University, Denizli, Turkey.
FAU - Tufaner, Gokhan
AU  - Tufaner G
FAU - Kaya, Huseyin
AU  - Kaya H
FAU - Kasikci, Alper
AU  - Kasikci A
FAU - Deda, Gokhan
AU  - Deda G
FAU - Pekel, Gokhan
AU  - Pekel G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*diagnostic imaging
MH  - Diabetic Retinopathy/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*diagnostic imaging
MH  - Organ Size
MH  - *Retinal Ganglion Cells
MH  - Tomography, Optical Coherence
PMC - PMC5521921
EDAT- 2017/07/21 06:00
MHDA- 2017/08/09 06:00
CRDT- 2017/07/21 06:00
AID - 10.1097/MD.0000000000007556 [doi]
AID - 00005792-201707210-00046 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(29):e7556. doi: 10.1097/MD.0000000000007556.