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Thrombocytopenia in pregnancy with different diagnoses: Differential clinical features, treatments, and outcomes.

Abstract To investigate the clinical features and perinatal treatment of thrombocytopenia induced by different causes during pregnancy.Clinical data from 195 pregnant women with thrombocytopenia attending 2 tertiary hospitals from January 2014 to October 2016 were retrospectively studied. The obtained data were analyzed with SPSS 19.0 software.There were 117 (60.0%), 55 (28.2%), and 23 cases (11.8%) of pregnancy-associated thrombocytopenia (PAT), idiopathic thrombocytopenia (ITP), and hypertensive disorder in pregnancy (PIH), respectively. The percentage of nulliparous women, gestational age at delivery, date of diagnosis of thrombocytopenia, and delivery mode significantly differed between the patients in these 3 groups (P < .05). Patients with PIH had a higher percentage of premature delivery and of lower birth weight infants than patients in the other 2 groups. The 3 groups had similar incidences of postpartum hemorrhage, rates of stillbirth, and neonatal Apgar scores at 5 minutes. PAT and PIH patients had different platelet counts after delivery compared with at diagnosis, whereas the platelet counts of the ITP patients were similar at diagnosis and after delivery. ITP patients in the nontreatment group and the treatment group had significantly different platelet counts (P < .05), and in the treatment group, the maternal platelet count did not differ for treatment with intravenous immunoglobulin (IVIg) versus corticosteroids.The causes of thrombocytopenia in pregnancy are diverse, and the clinical features vary widely. Timely analysis is needed to determine the primary cause of thrombocytopenia, and appropriate therapy should then be selected to effectively improve the prognosis of pregnancies.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28723784
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170808
LR  - 20170808
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 29
DP  - 2017 Jul
TI  - Thrombocytopenia in pregnancy with different diagnoses: Differential clinical
      features, treatments, and outcomes.
PG  - e7561
LID - 10.1097/MD.0000000000007561 [doi]
AB  - To investigate the clinical features and perinatal treatment of thrombocytopenia 
      induced by different causes during pregnancy.Clinical data from 195 pregnant
      women with thrombocytopenia attending 2 tertiary hospitals from January 2014 to
      October 2016 were retrospectively studied. The obtained data were analyzed with
      SPSS 19.0 software.There were 117 (60.0%), 55 (28.2%), and 23 cases (11.8%) of
      pregnancy-associated thrombocytopenia (PAT), idiopathic thrombocytopenia (ITP),
      and hypertensive disorder in pregnancy (PIH), respectively. The percentage of
      nulliparous women, gestational age at delivery, date of diagnosis of
      thrombocytopenia, and delivery mode significantly differed between the patients
      in these 3 groups (P &lt; .05). Patients with PIH had a higher percentage of
      premature delivery and of lower birth weight infants than patients in the other 2
      groups. The 3 groups had similar incidences of postpartum hemorrhage, rates of
      stillbirth, and neonatal Apgar scores at 5 minutes. PAT and PIH patients had
      different platelet counts after delivery compared with at diagnosis, whereas the 
      platelet counts of the ITP patients were similar at diagnosis and after delivery.
      ITP patients in the nontreatment group and the treatment group had significantly 
      different platelet counts (P &lt; .05), and in the treatment group, the maternal
      platelet count did not differ for treatment with intravenous immunoglobulin
      (IVIg) versus corticosteroids.The causes of thrombocytopenia in pregnancy are
      diverse, and the clinical features vary widely. Timely analysis is needed to
      determine the primary cause of thrombocytopenia, and appropriate therapy should
      then be selected to effectively improve the prognosis of pregnancies.
FAU - Wang, Xiaoyue
AU  - Wang X
AD  - aDepartment of Hematology, No. 454 Hospital of PLA, Nanjing bDepartment of
      Obstetrics and Gynecology, Huai'an Second People's Hospital, Huai'an, Jiangsu
      cDepartment of Obstetrics and Gynecology, No. 454 Hospital of PLA, Nanjing,
      People's Republic of China.
FAU - Xu, Yan
AU  - Xu Y
FAU - Luo, Wenxiang
AU  - Luo W
FAU - Feng, Hui
AU  - Feng H
FAU - Luo, Yizhou
AU  - Luo Y
FAU - Wang, Yanli
AU  - Wang Y
FAU - Liao, Hui
AU  - Liao H
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Hypertension/diagnosis/drug therapy
MH  - Platelet Count
MH  - Pregnancy
MH  - Pregnancy Complications/*diagnosis/*drug therapy
MH  - Pregnancy Outcome
MH  - Retrospective Studies
MH  - Tertiary Care Centers
MH  - Thrombocytopenia/*diagnosis/*drug therapy
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC5521924
EDAT- 2017/07/21 06:00
MHDA- 2017/08/09 06:00
CRDT- 2017/07/21 06:00
AID - 10.1097/MD.0000000000007561 [doi]
AID - 00005792-201707210-00049 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(29):e7561. doi: 10.1097/MD.0000000000007561.