PubTransformer

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PMID- 28723785
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170808
LR  - 20170808
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 29
DP  - 2017 Jul
TI  - Asymptomatic congenital tuberculosis: A case report.
PG  - e7562
LID - 10.1097/MD.0000000000007562 [doi]
AB  - RATIONALE: Congenital tuberculosis (TB) is described as a rare, but severe
      disease. In contrast to the cases with severe symptoms reported so far, we
      describe a child with asymptomatic congenital TB. PATIENT CONCERNS: An 8-week-old
      girl was investigated because of newly diagnosed TB in her mother, which
      complained about cough since 21 weeks gestation. Lung biopsy tissue specimens of 
      the mother revealed necrotizing granuloma with a single acid-fast bacillus (AFB) 
      and Mycobacterium tuberculosis (MTB) was detected by polymerase chain reaction.
      Bronchoalveolar lavage was negative for AFB smear and culture, arguing against
      postnatal transmission of MTB. TB contact investigations were negative. The
      child, at the age of 8 weeks at first assessment, was in an excellent general
      condition and diagnosed with congenital TB by culture-positive lung TB and
      exclusion of postnatal transmission. DIAGNOSES: The child fulfilled Cantwell
      criteria to diagnose congenital TB. INTERVENTIONS: Ambulatory anti-tuberculosis
      treatment was initiated for 6 months. OUTCOMES: The 18 months follow-up was
      uneventful. LESSONS: This case of asymptomatic congenital TB in a young child
      illustrates the diagnostic difficulties in congenital TB and raises the question 
      whether congenital TB is underestimated.
FAU - Meyer Sauteur, Patrick M
AU  - Meyer Sauteur PM
AD  - aDivision of Infectious Diseases and Hospital Epidemiology bChildren's Research
      Center, University Children's Hospital Zurich cDivision of Clinical Pathology,
      University Hospital Zurich dInstitute of Medical Microbiology eSwiss National
      Center for Mycobacteria, University of Zurich fDepartment of Pulmonology,
      University Hospital Zurich, Zurich, Switzerland.
FAU - Marques-Maggio, Ewerton
AU  - Marques-Maggio E
FAU - Relly, Christa
AU  - Relly C
FAU - Keller, Peter M
AU  - Keller PM
FAU - Clarenbach, Christian F
AU  - Clarenbach CF
FAU - Berger, Christoph
AU  - Berger C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antitubercular Agents)
SB  - AIM
SB  - IM
MH  - Antitubercular Agents/therapeutic use
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Infant
MH  - Tuberculosis, Pulmonary/*congenital/*diagnosis/drug therapy/pathology
PMC - PMC5521925
EDAT- 2017/07/21 06:00
MHDA- 2017/08/09 06:00
CRDT- 2017/07/21 06:00
AID - 10.1097/MD.0000000000007562 [doi]
AID - 00005792-201707210-00050 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(29):e7562. doi: 10.1097/MD.0000000000007562.