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Risk factors of lymph node metastasis in lung squamous cell carcinoma of 3 cm or less in diameter.

Abstract Through literature review we cannot find an efficient risk factor of lymph node metastasis in lung squamous cell carcinoma (SCC). This study aimed to investigate the risk factors of pathological lymph node status in patients with lung SCC of 3 cm or less in diameter, to provide some reference for the fellow surgeons in the decision of operative option.In total, we analyzed 154 patients with lung SCC of 3 cm or less in diameter who underwent lobectomy or bilobectomy or pneumonectomy with systematic lymph node dissection. The relationship between lymph node status and clinical characteristics were examined.Lymph node metastases were present in 48 patients (31.2%) of the study subjects. Multivariate analysis indicated that, age <60 years old (P = .007), tumor location of central-type (P = .003), tumor long axis >2 cm but ≤3 cm (P = .047) were associated with lymph node metastasis, and their odd ratios (OR) were 3.120, 3.359, and 5.196, respectively. Group analysis of the 74 peripheral lung SCC showed that those with the tumor long axis ≤2 cm had a lower rate of lymph node metastasis (7.9% vs 27.8%, P = .025).Age <60 years old, tumor location of central-type, and tumor long axis >2 cm but ≤3 cm are risk factors of lymph node metastasis in lung SCC. Systematic lymph node dissection or sampling is recommended when tumor central-type location and/or long axis >2 cm in lung SCC are present.
PMID
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Authors

Mayor MeshTerms

Lymphatic Metastasis

Keywords
Journal Title medicine
Publication Year Start




PMID- 28723786
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170808
LR  - 20170808
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 29
DP  - 2017 Jul
TI  - Risk factors of lymph node metastasis in lung squamous cell carcinoma of 3 cm or 
      less in diameter.
PG  - e7563
LID - 10.1097/MD.0000000000007563 [doi]
AB  - Through literature review we cannot find an efficient risk factor of lymph node
      metastasis in lung squamous cell carcinoma (SCC). This study aimed to investigate
      the risk factors of pathological lymph node status in patients with lung SCC of 3
      cm or less in diameter, to provide some reference for the fellow surgeons in the 
      decision of operative option.In total, we analyzed 154 patients with lung SCC of 
      3 cm or less in diameter who underwent lobectomy or bilobectomy or pneumonectomy 
      with systematic lymph node dissection. The relationship between lymph node status
      and clinical characteristics were examined.Lymph node metastases were present in 
      48 patients (31.2%) of the study subjects. Multivariate analysis indicated that, 
      age &lt;60 years old (P = .007), tumor location of central-type (P = .003), tumor
      long axis &gt;2 cm but &lt;/=3 cm (P = .047) were associated with lymph node
      metastasis, and their odd ratios (OR) were 3.120, 3.359, and 5.196, respectively.
      Group analysis of the 74 peripheral lung SCC showed that those with the tumor
      long axis &lt;/=2 cm had a lower rate of lymph node metastasis (7.9% vs 27.8%, P =
      .025).Age &lt;60 years old, tumor location of central-type, and tumor long axis &gt;2
      cm but &lt;/=3 cm are risk factors of lymph node metastasis in lung SCC. Systematic 
      lymph node dissection or sampling is recommended when tumor central-type location
      and/or long axis &gt;2 cm in lung SCC are present.
FAU - Huang, Lijian
AU  - Huang L
AD  - aDepartment of Thoracic Surgery bPathology Department, 2nd Affiliated Hospital,
      School of Medicine, Zhejiang University, Hangzhou, China.
FAU - Li, Wenshan
AU  - Li W
FAU - Zhao, Lufeng
AU  - Zhao L
FAU - Li, Baizhou
AU  - Li B
FAU - Chai, Ying
AU  - Chai Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*epidemiology/*pathology/surgery
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*epidemiology/*pathology/surgery
MH  - *Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Risk Factors
MH  - Tumor Burden
PMC - PMC5521926
EDAT- 2017/07/21 06:00
MHDA- 2017/08/09 06:00
CRDT- 2017/07/21 06:00
AID - 10.1097/MD.0000000000007563 [doi]
AID - 00005792-201707210-00051 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(29):e7563. doi: 10.1097/MD.0000000000007563.