Moist exposed burn ointment for treating pressure ulcers: A multicenter randomized controlled trial.
|Abstract||Pressure ulcers often seriously affect the quality of life of patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients with pressure ulcers. The present study aimed to evaluate the efficacy and safety of MEBO in the treatment of pressure ulcers in Chinese patients.|
Moist Exposed Burn Ointment (MEBO) in partial thickness burns - a randomized, comparative open mono-center study on the efficacy of dermaheal (MEBO) ointment on thermal 2nd degree burns compared to conventional therapy.
Evaluating the role of alternative therapy in burn wound management: randomized trial comparing moist exposed burn ointment with conventional methods in the management of patients with second-degree burns.
|Publication Year Start||2017-01-01|
PMID- 28723796 OWN - NLM STAT- MEDLINE DA - 20170720 DCOM- 20170808 LR - 20170808 IS - 1536-5964 (Electronic) IS - 0025-7974 (Linking) VI - 96 IP - 29 DP - 2017 Jul TI - Moist exposed burn ointment for treating pressure ulcers: A multicenter randomized controlled trial. PG - e7582 LID - 10.1097/MD.0000000000007582 [doi] AB - BACKGROUND: Pressure ulcers often seriously affect the quality of life of patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients with pressure ulcers. The present study aimed to evaluate the efficacy and safety of MEBO in the treatment of pressure ulcers in Chinese patients. METHODS: Seventy-two patients with pressure ulcers were randomly assigned to 2 groups who received a placebo or MEBO for 2 months. The primary outcomes included the wound surface area (WSA) and pressure ulcer scale for healing (PUSH) tool. The secondary outcomes included a visual analog scale (VAS), questionnaire of ulcer status, and adverse effects. RESULTS: Sixty-seven patients completed the study. After 2 months of treatment, the difference of mean change from the baseline was greater for MEBO (vs placebo) for WSA mean (SD) -6.0 (-8.8, -3.3), PUSH Tool -2.6 (-4.7, -1.5), and VAS score -2.9 (-4.4, -1.7). On the basis of the questionnaire, the pressure ulcers were "completely healed" (50.0% vs 16.7%) (P < .05) in patients after 2 months of treatment with MEBO versus placebo. No major adverse effects were found in the 2 groups. CONCLUSION: We showed that MEBO is effective and well tolerated for improving wound healing in Chinese patients with pressure ulcers. FAU - Li, Wei AU - Li W AD - aDepartment of Medical Science Institute of Harbin, the First Hospital of Harbin, Harbin Medical University, Harbin bDepartment of Orthopedics, Hongqi Hospital of Mudanjiang Medical College, Mudanjiang cDepartment of Study Center, the First Affiliated Hospital of Harbin Medical University, Harbin, China. FAU - Ma, Yubo AU - Ma Y FAU - Yang, Qi AU - Yang Q FAU - Pan, Yu AU - Pan Y FAU - Meng, Qinggang AU - Meng Q LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Drugs, Chinese Herbal) RN - 0 (Sitosterols) RN - 0 (moist exposed burn ointment) SB - AIM SB - IM MH - Aged MH - China MH - Drugs, Chinese Herbal/adverse effects/*therapeutic use MH - Female MH - Humans MH - Male MH - Pain Measurement MH - Pressure Ulcer/*drug therapy/pathology MH - Severity of Illness Index MH - Sitosterols/adverse effects/*therapeutic use MH - Surveys and Questionnaires MH - Treatment Outcome MH - Wound Healing/drug effects PMC - PMC5521936 EDAT- 2017/07/21 06:00 MHDA- 2017/08/09 06:00 CRDT- 2017/07/21 06:00 AID - 10.1097/MD.0000000000007582 [doi] AID - 00005792-201707210-00061 [pii] PST - ppublish SO - Medicine (Baltimore). 2017 Jul;96(29):e7582. doi: 10.1097/MD.0000000000007582.