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PMID- 28723796
DA  - 20170720
DCOM- 20170808
LR  - 20170808
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 29
DP  - 2017 Jul
TI  - Moist exposed burn ointment for treating pressure ulcers: A multicenter
      randomized controlled trial.
PG  - e7582
LID - 10.1097/MD.0000000000007582 [doi]
AB  - BACKGROUND: Pressure ulcers often seriously affect the quality of life of
      patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients
      with pressure ulcers. The present study aimed to evaluate the efficacy and safety
      of MEBO in the treatment of pressure ulcers in Chinese patients. METHODS:
      Seventy-two patients with pressure ulcers were randomly assigned to 2 groups who 
      received a placebo or MEBO for 2 months. The primary outcomes included the wound 
      surface area (WSA) and pressure ulcer scale for healing (PUSH) tool. The
      secondary outcomes included a visual analog scale (VAS), questionnaire of ulcer
      status, and adverse effects. RESULTS: Sixty-seven patients completed the study.
      After 2 months of treatment, the difference of mean change from the baseline was 
      greater for MEBO (vs placebo) for WSA mean (SD) -6.0 (-8.8, -3.3), PUSH Tool -2.6
      (-4.7, -1.5), and VAS score -2.9 (-4.4, -1.7). On the basis of the questionnaire,
      the pressure ulcers were "completely healed" (50.0% vs 16.7%) (P < .05) in
      patients after 2 months of treatment with MEBO versus placebo. No major adverse
      effects were found in the 2 groups. CONCLUSION: We showed that MEBO is effective 
      and well tolerated for improving wound healing in Chinese patients with pressure 
FAU - Li, Wei
AU  - Li W
AD  - aDepartment of Medical Science Institute of Harbin, the First Hospital of Harbin,
      Harbin Medical University, Harbin bDepartment of Orthopedics, Hongqi Hospital of 
      Mudanjiang Medical College, Mudanjiang cDepartment of Study Center, the First
      Affiliated Hospital of Harbin Medical University, Harbin, China.
FAU - Ma, Yubo
AU  - Ma Y
FAU - Yang, Qi
AU  - Yang Q
FAU - Pan, Yu
AU  - Pan Y
FAU - Meng, Qinggang
AU  - Meng Q
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Sitosterols)
RN  - 0 (moist exposed burn ointment)
SB  - IM
MH  - Aged
MH  - China
MH  - Drugs, Chinese Herbal/adverse effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Pain Measurement
MH  - Pressure Ulcer/*drug therapy/pathology
MH  - Severity of Illness Index
MH  - Sitosterols/adverse effects/*therapeutic use
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Wound Healing/drug effects
PMC - PMC5521936
EDAT- 2017/07/21 06:00
MHDA- 2017/08/09 06:00
CRDT- 2017/07/21 06:00
AID - 10.1097/MD.0000000000007582 [doi]
AID - 00005792-201707210-00061 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(29):e7582. doi: 10.1097/MD.0000000000007582.