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Correlation between elevated platelet count and immunoglobulin levels in the early convalescent stage of Kawasaki disease.

Abstract Kawasaki disease (KD) may be an acute systemic immune-mediated disease which occurs after infection of unknown KD pathogen(s). The aim of this study is to evaluate the changes in platelet count and immunoglobulin (Ig) levels (IgG, IgM, IgA, and IgE) during hospitalization.Forty-three patients with complete KD who received intravenous Ig at 2 g/kg were enrolled in South Korea. The platelet count and Ig levels of the patients were examined twice at presentation and around discharge (mean 6.2 ± 2.4 days apart) and the relationships between platelet level and Ig levels were evaluated.The mean patient age was 31 ± 18 months; 28 patients were male and 15 were female. The values of all parameters measured, with the exception of IgE, were significantly increased at the second examination compared with their values at presentation. These values gradually increased over time after fever onset, over periods ranging from 2 to 16 days. The extent by which platelet levels increased over these 2 time points was correlated with the extents by which IgG (P < .01), IgM (P < .01), and IgA levels (P = .01) increased.Both the platelet count and the Ig (IgG, IgM, and IgA) levels increased with a correlation each other during the early convalescent stage of KD. This finding suggests that all Ig subtypes except IgE and platelets may be involved in the recovery from KD and that the extent of increased parameters may reflect the degree of systemic inflammation in acute KD.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28723797
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170808
LR  - 20170808
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 29
DP  - 2017 Jul
TI  - Correlation between elevated platelet count and immunoglobulin levels in the
      early convalescent stage of Kawasaki disease.
PG  - e7583
LID - 10.1097/MD.0000000000007583 [doi]
AB  - Kawasaki disease (KD) may be an acute systemic immune-mediated disease which
      occurs after infection of unknown KD pathogen(s). The aim of this study is to
      evaluate the changes in platelet count and immunoglobulin (Ig) levels (IgG, IgM, 
      IgA, and IgE) during hospitalization.Forty-three patients with complete KD who
      received intravenous Ig at 2 g/kg were enrolled in South Korea. The platelet
      count and Ig levels of the patients were examined twice at presentation and
      around discharge (mean 6.2 +/- 2.4 days apart) and the relationships between
      platelet level and Ig levels were evaluated.The mean patient age was 31 +/- 18
      months; 28 patients were male and 15 were female. The values of all parameters
      measured, with the exception of IgE, were significantly increased at the second
      examination compared with their values at presentation. These values gradually
      increased over time after fever onset, over periods ranging from 2 to 16 days.
      The extent by which platelet levels increased over these 2 time points was
      correlated with the extents by which IgG (P &lt; .01), IgM (P &lt; .01), and IgA levels
      (P = .01) increased.Both the platelet count and the Ig (IgG, IgM, and IgA) levels
      increased with a correlation each other during the early convalescent stage of
      KD. This finding suggests that all Ig subtypes except IgE and platelets may be
      involved in the recovery from KD and that the extent of increased parameters may 
      reflect the degree of systemic inflammation in acute KD.
FAU - Han, Ji-Whan
AU  - Han JW
AD  - aDepartment of Pediatrics, College of Medicine, The Catholic University of Korea,
      Seoul bDepartment of Pediatrics, Daejeon St. Mary's Hospital, College of
      Medicine, The Catholic University of Korea, Daejeon, Republic of Korea.
FAU - Oh, Jin-Hee
AU  - Oh JH
FAU - Rhim, Jung-Woo
AU  - Rhim JW
FAU - Lee, Kyung-Yil
AU  - Lee KY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulins)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Disease Progression
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Immunoglobulins/blood
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Immunologic Factors/therapeutic use
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*blood/*immunology/therapy
MH  - Platelet Count
MH  - Republic of Korea
MH  - Retrospective Studies
MH  - Time Factors
PMC - PMC5521937
EDAT- 2017/07/21 06:00
MHDA- 2017/08/09 06:00
CRDT- 2017/07/21 06:00
AID - 10.1097/MD.0000000000007583 [doi]
AID - 00005792-201707210-00062 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(29):e7583. doi: 10.1097/MD.0000000000007583.