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PMID- 28723807
STAT- In-Process
DA  - 20170720
LR  - 20170801
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 29
DP  - 2017 Jul
TI  - Can patients with femoral neck fracture benefit from preoperative
      thromboprophylaxis?: A prospective randomized controlled trial.
PG  - e7604
LID - 10.1097/MD.0000000000007604 [doi]
AB  - BACKGROUND: The effectiveness of preoperative thromboprophylaxis remains obscure 
      in patients with femoral neck fracture. The purpose of the current study was to
      investigate whether these patients benefit from preoperative thromboprophylaxis. 
      METHODS: In this prospective, randomized controlled trial, a total of 80 patients
      with femoral neck fracture were randomly assigned to receive either rivaroxaban
      or conservative treatment before surgery. For all patients, color Doppler
      ultrasound of both lower extremities was performed immediately after admission.
      The primary efficacy outcome was venous thromboembolism (VTE) defined as deep
      vein thrombosis (DVT) or pulmonary embolism (PE). The primary safety outcome was 
      major bleeding. RESULT: Compared with conservative treatment, rivaroxaban could
      significantly reduce the incidence of DVT from 19.5% (8/41) to 2.6% (1/39) (P =
      .016). Preoperatively, there were a total of 9 occurrences of DVT including 8 DVT
      in the conservative treatment group and 1 in the oral rivaroxaban group. All
      cases of DVT were asymptomatic, with 8 of them diagnosed as isolated muscular
      calf vein thromboses. There were no differences between the 2 groups in terms of 
      the overall incidence of major bleeding. CONCLUSION: Thromboprophylaxis with
      rivaroxaban prior to surgery can effectively reduce the risk of preoperative DVT 
      for patients with femoral neck fracture without increasing the risk of bleeding.
FAU - Li, Qiangqiang
AU  - Li Q
AD  - aDepartment of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum
      Tower Hospital, Clinical College of Nanjing Medical University bLaboratory for
      Bone and Joint Diseases, Model Animal Research Center, Nanjing University
      cDepartment of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum
      Tower Hospital Affiliated with the Medical School of Nanjing University, Nanjing,
      Jiangsu dDepartment of Orthopedics, The first Affiliated Hospital of Nantong
      University, Nantong eNingBo No.6 Hospital, Ningbo, P.R. China.
FAU - Dai, Bingyang
AU  - Dai B
FAU - Xu, Jiacheng
AU  - Xu J
FAU - Yao, Yao
AU  - Yao Y
FAU - Song, Kai
AU  - Song K
FAU - Zhang, Haojun
AU  - Zhang H
FAU - Chen, Dongyang
AU  - Chen D
FAU - Jiang, Qing
AU  - Jiang Q
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
PMC - PMC5521947
EDAT- 2017/07/21 06:00
MHDA- 2017/07/21 06:00
CRDT- 2017/07/21 06:00
AID - 10.1097/MD.0000000000007604 [doi]
AID - 00005792-201707210-00072 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(29):e7604. doi: 10.1097/MD.0000000000007604.